Microvessel Density and Expression of Vascular Endothelial Growth Factor in Ovarian Endometriosis

Objective To investigate the expression of vascular endothelial growth factor(VEGF) and angiogenesis in endometriosis and it relationship with clinical pathogene-sis. Methods S-P immunohistochemical method was used to detect VEGF expression and MVD in Lesions in 50 cases of ovarian endometrioma ,endometrium in 21 cases of myoma and 10 cas-es of adenomyosis. Results The positive rate of VEGF in ovarian endometrioma was 13.69±4.32 in epithelium, 9.24±6.55 in stroma MVD (160±53/mm2 ) was higher in endometrioma than in eutopic endometrium of myoma and adenomyosis. The difference was significant(P 0.05) .There was positive relation between MVD and VEGF positive rate.According to (r-AFS) stage,there were no significance in positive rate of VEGF and MVD between 15 cases of Stage Ⅰ-Ⅱ and 35 cases of Stage Ⅲ -Ⅳ groups (P 0.05) . No correlation was found in clinical stage of endometriosis. Conclusion Overexpression VEGF of endometriotic tissue may partici-pate in angiogenesis process. It could be a theoretical basis for the treatment of endometriosis by an-ti-angiogenesis.