Pathological Features and Immunohistochemical Characteristics of Clear Cell (Glycogen-Rich) Urothelial Carcinoma: A Case Report and Systematic Review of the Literature

Pathological Features and Immunohistochemical Characteristics of Clear Cell (Glycogen-Rich) Urothelial Carcinoma: A Case Report and Systematic Review of the Literature | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Pathological Features and Immunohistochemical Characteristics of Clear Cell (Glycogen-Rich) Urothelial Carcinoma: A Case Report and Systematic Review of the Literature weiming wang, Baogang Zhang, Zhangli Wu, Chuanling Hou, mengyao li, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5143923/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 10 You are reading this latest preprint version Abstract Clear cell (glycogen-rich) urothelial carcinoma is an exceedingly rare variant of invasive urothelial carcinoma, distinguished by the presence of abundant cytoplasmic glycogen, which imparts a clear appearance to the tumor cells under histological examination. In this case report, the diagnosis was established through histopathological evaluation with hematoxylin and eosin (HE) staining, immunohistochemical analysis, and the identification of significant cytoplasmic glycogen accumulation. The patient, an 89-year-old male, was admitted on July 24, 2024, presenting with painless gross hematuria persisting for one week. Abdominal ultrasound and CT urography revealed a soft tissue mass on the right side of the bladder wall, measuring 30×30 mm, with a broad base connected to the bladder wall. The mass exhibited significant enhancement on contrast-enhanced scans, raising suspicion for malignancy. Microscopic examination revealed two distinct tumor cell morphologies: the conventional urothelial carcinoma pattern and a clear nest-like morphology, with the latter comprising over 70% of the tumor. Immunohistochemical staining for GATA-3, CK7, PAS, PAS-D, CAIX,PAX8,and RCC confirmed the diagnosis of clear cell (glycogen-rich) urothelial carcinoma. This rare variant of invasive urothelial carcinoma underscores the need for detailed diagnostic analysis to inform prognosis and treatment strategies. Clear Cell Urothelial Carcinoma Rare PAS Staining Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 25 Nov, 2024 Reviews received at journal 24 Nov, 2024 Reviewers agreed at journal 17 Nov, 2024 Reviews received at journal 13 Nov, 2024 Reviewers agreed at journal 08 Nov, 2024 Reviewers agreed at journal 06 Nov, 2024 Reviewers invited by journal 24 Oct, 2024 Editor assigned by journal 09 Oct, 2024 Submission checks completed at journal 08 Oct, 2024 First submitted to journal 24 Sep, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5143923","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":382215651,"identity":"8699cb7f-ece1-469d-9c13-67882cc0046d","order_by":0,"name":"weiming wang","email":"","orcid":"","institution":"Shaoxing People's Hospital","correspondingAuthor":false,"prefix":"","firstName":"weiming","middleName":"","lastName":"wang","suffix":""},{"id":382215652,"identity":"74d968f9-3672-4ad2-ba0f-51ed912c55b9","order_by":1,"name":"Baogang 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