Primary endometrial endometrioid carcinoma with signet ring cells: why is this a special case?

Abstract A 76 years old woman presented to our emergency department because of post-menopausal bleeding in June 2019. Gynaecological ultrasound was performed detecting an heterogeneous endometrial thickness of 9,3 mm. An endometrial biopsy with Novak system was performed showing an endometrioid adenocarcinoma. A total hysterectomy with adnexectomy along with lymph node dissection and pelvic washing was performed for tumour staging. Anatomopathological and histological evaluationrevealed a primary endometrial endometrioid adenocarcinoma with signet ring cells that was confirmed by immunohistochemical studies and imaging/endoscopic studies that excluded non-gynaecological tumour origin.