Reinforcing MgO nanoparticles with 3D printed sodium alginate/silk fibroin/polyvinyl alcohol/nano-hydroxyapatite composite structure enhanced biomimetic potential for defect bone tissue repair.

Reinforcing MgO nanoparticles with 3D printed sodium alginate/silk fibroin/polyvinyl alcohol/nano-hydroxyapatite composite structure enhanced biomimetic potential for defect bone tissue repair. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 21 January 2025 V1 Latest version Share on Reinforcing MgO nanoparticles with 3D printed sodium alginate/silk fibroin/polyvinyl alcohol/nano-hydroxyapatite composite structure enhanced biomimetic potential for defect bone tissue repair. Authors : Partha Sarathi Majhi 0000-0002-1320-6740 and Krishna Pramanik 0000-0001-6897-4328 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173746830.02990143/v1 264 views 122 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The current research investigates the effect of reinforcing magnesium oxide nanoparticles (n-MgO) on the physico-chemical, mechanical, and cellular activities of our previously developed three-dimensional printed sodium alginate (SA)/silk fibroin (SF)/polyvinyl alcohol (PVA)/nano-hydroxyapatite (HA) composite scaffold with optimized composition containing SA/SF:70:30 (v/v) with 3wt% PVA tri-polymer ratio and 1.5wt% n-HA designated as SA 70 /SF 30 /PVA 3 /n-HA 1.5 proven to be a suitable matrix for bone tissue engineering application. The chemically synthesized n-MgO was incorporated at two different concentrations of 0.5 wt% and 1 wt% into the SA/SF/PVA/n-HA solution and the resulting composite bioinks were used to fabricate 3D printed scaffolds as SA 70 /SF 30 /PVA 3 /n-HA 1.5 /n-MgO 0.5 and SA 70 /SF 30 /PVA 3 /n-HA 1.5 /n-MgO 1 . The scaffolds possess a microfibrous interconnected porous network with desired pore sizes ranging from 384±74µm and 362±57µm. The tensile strength measuring 4.09±1.13 MPa and 5.08±1.14 MPa for SA 70 /SF 30 /PVA 3 /n-HA 1.5 /n-MgO 0.5 and SA 70 /SF 30 /PVA 3 /n-HA 1.5 /n-MgO 1 was enhanced upon reinforcing n-MgO matching with the mechanical strength of a cancellous bone and suitable for bone tissue regeneration under the load condition. In-vitro cell studies performed with HOS cells have shown the cytocompatible properties of the SA 70 /SF 30 /PVA 3 /n-HA 1.5 /n-MgO 1 scaffold. The up-regulation of ALP activity indicated that the scaffold might support superior osteoblast function and differentiation. Supplementary Material File (manuscript.docx) Download 2.57 MB Information & Authors Information Version history V1 Version 1 21 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords 3d printing magnesium oxide nanoparticles nano-hydroxyapatite polyvinyl alcohol silk fibroin sodium alginate Authors Affiliations Partha Sarathi Majhi 0000-0002-1320-6740 National Institute of Technology Rourkela Department of Biotechnology and Medical Engineering View all articles by this author Krishna Pramanik 0000-0001-6897-4328 [email protected] National Institute of Technology Rourkela Department of Biotechnology and Medical Engineering View all articles by this author Metrics & Citations Metrics Article Usage 264 views 122 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Partha Sarathi Majhi, Krishna Pramanik. Reinforcing MgO nanoparticles with 3D printed sodium alginate/silk fibroin/polyvinyl alcohol/nano-hydroxyapatite composite structure enhanced biomimetic potential for defect bone tissue repair.. Authorea . 21 January 2025. DOI: https://doi.org/10.22541/au.173746830.02990143/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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