Characteristics of Blood Tests in norovirus-associated Benign Convulsions with Mild Gastroenteritis in Children

Purpose: Benign convulsions with mild gastroenteritis (CWG) is a common condition in children in Asia , and the prognosis is generally good,However, the diagnosis of CWG is an exclusive diagnosis and attention should be paid to the exclusion of potential intracranial diseases. This study analyzed the clinical features of norovirus associated CWG to provide evidence for reducing unnecessary tests. Methods: : Medical records of children admitted to the Department of Emergency of Guangzhou Women and Children′s Medical Center with Stool etiology was positive for norovirus between January 2019 and January 2020 were divided into CWG group and simple gastroenteritis group ,and were reviewed and analyzed. Results: : A total of 89 norovirus cases were enrolled . Age of onset, male/female ratio of CWG group and simple gastroenteritis group were 49 cases, mean 20.84 ± 5.83 months and 27:22, 40 cases, mean 19.00 ± 13.48 months and, 26:14，respectively.Serum uric acid levels in CwG and acute gastroenteritis groups increased in 43 (87.8%) and 9 (22.5%) cases, respectively. The average serum uric acid level in the CwG group was significantly higher than that in the acute gastroenteritis group (564.36±125.28umol/L vs 338.42±141.03umol/L [mean±standard deviation], p<0.0001) .The potential of hydrogen（PH）， bicarbonate（HCO3 – ），BE bases excess（BE），blood glucose ,Serum sodium and white blood cell(WBC) of CWG group were also lower than those of simple gastroenteritis group, the differences were statistically significant, while there were no significant differences in transaminase、residual myocardial enzymes, electrolytes and C-reactive protein(CRP ),etc. Conclusion: Children with norovirus diarrhea with recurrent convulsions, increased serum uric acid, more obvious acidosis should pay high attention to the possibility of Norovirus related CWG, lumbar puncture and Cranial imaging are unnecessary and should not be recommended.