Effects of progesterone administered by nasal spray on the human postmenopausal endometrium

E. Cicinelli, Ettore Cicinelli, D. Petruzzi, P. Scorcia, Leonardo Resta, L Resta
Maturitas · 1993 · vol. 18(1) , pp. 65–72 · doi:10.1016/0378-5122(93)90030-l · PMID:8107618 · W2026255943
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Nasal spray progesterone induced secretory changes in the postmenopausal endometrium of women pretreated with estrogens, but failed to do so in those receiving progesterone alone.

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Abstract

The aim of the study was to assess the effectiveness of progesterone (P) administered by nasal spray (NS) in inducing secretory changes within estrogen and non-estrogen primed postmenopausal endometrium. Ten healthy post-menopausal women before vaginal hysterectomy for prolapse were randomly treated by either oral estrogens for 3-4 weeks combined for the last 5-7 days with nasally administered P at the daily dose of 34 mg, or by only P for 6 days. Endometrial samples were taken before P administration and 8 h after the last dose. In the group not treated with estrogens, P did not induce significant secretory changes in any case except one which showed a proliferative endometrial pattern at the first evaluation. In the group treated with estrogens, in all the cases after P administration clear secretory changes (abundant vacuoles, endoluminal secretion) occurred. It is possible to conclude that P administered by NS exerts an end-organ effect within the endometrium of postmenopausal women pretreated with estrogens.

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MeSH descriptors

Endometrium Postmenopause Progesterone Administration, Intranasal Administration, Oral Adult Aged Endometrium Endometrium Endometrium Estrogen Replacement Therapy Female Humans Middle Aged Progesterone Progesterone

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References (22)

SciLite annotations

chemicals 7
progesterone progesterone estrogen estrone estrone estrone estrone
organisms 1
human

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