Adaptability analysis of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone in China
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Abstract
We describe nine internationally spreading ceftriaxone-resistant FC428 clone-related Neisseria gonorrhoeae strains with a typical ceftriaxone-resistant phenotype (MIC ≥ 0.5 mg/L) isolated from Guangzhou and Shanghai between 2019 and 2020. The adaptability analysis further involved all FC428-related N. gonorrhoeae strains reported in China and our data demonstrated that three representative clones (MLST-ST1903_NG-STAR-ST1143, MLST-ST1600_NG-STAR-ST2208, and MLST-ST13943_NG-STAR-ST233) were observed to settle in China in evolution. Specifically, enhancing antimicrobial resistance surveillance of the three representative clones is crucial for understanding the transmission trajectory and optimizing therapy strategies.
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- last seen: 2026-05-19T01:45:01.086888+00:00
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License: CC-BY-4.0