Association between Serum Vitamin D Levels and Respiratory Infections in Hospitalized Children: A Case-Control Study

Association between Serum Vitamin D Levels and Respiratory Infections in Hospitalized Children: A Case-Control Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 February 2025 V1 Latest version Share on Association between Serum Vitamin D Levels and Respiratory Infections in Hospitalized Children: A Case-Control Study Authors : Mehdi Jalili Akbarian , Mahta Mohtashami , Morteza Rasti Sani , Mahboubeh Neamatshahi , and Samad Nazemi 0000-0002-5081-6273 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173976484.42666183/v1 172 views 83 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Introduction : Vitamin D plays a critical role in immune function, and its deficiency has been linked to an increased risk of respiratory infections. This study investigates the association between serum 1,25-dihydroxyvitamin D levels and respiratory infections in hospitalized children. Methods : This case-control study was conducted at Heshmatieh Hospital, Sabzevar, Iran, involving 170 children (85 cases, 85 controls) aged 1 month to 16 years. The case group included children diagnosed with lower respiratory tract infections (LRTIs), while the control group comprised children hospitalized for non-infectious conditions. Serum 1,25-dihydroxyvitamin D levels were measured using ELISA, and inflammatory markers (WBC count, PMN percentage, ESR, and CRP) were analyzed. Chest X-ray (CXR) findings were evaluated. Results : Children with LRTIs had significantly lower serum vitamin D levels compared to controls (P = 0.021). Vitamin D deficiency (<30 nmol/L) was observed in 64.7% of cases and 32.8% of controls (P = 0.03). Inflammatory markers were elevated in cases, and CXR abnormalities were found in 74.2% of pneumonia patients, with bronchopneumonia being most common (61.8%). No significant difference in vitamin D deficiency between viral and bacterial pneumonia was detected (P = 0.54). Conclusions : This study highlights a significant association between lower serum vitamin D levels and respiratory infections in children, emphasizing the potential role of vitamin D in immune defense. Screening and supplementation strategies may be beneficial for at-risk pediatric populations. Supplementary Material File (initial manuscript main document.docx) Download 161.42 KB Information & Authors Information Version history V1 Version 1 17 February 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords 25-dihydroxyvitamin d child hospitalized pneumonia respiratory tract infections vitamin d deficiency Authors Affiliations Mehdi Jalili Akbarian Sabzevar University of Medical Sciences View all articles by this author Mahta Mohtashami Sabzevar University of Medical Sciences Leishmaniasis Research Center View all articles by this author Morteza Rasti Sani Sabzevar University of Medical Sciences View all articles by this author Mahboubeh Neamatshahi Sabzevar University of Medical Sciences View all articles by this author Samad Nazemi 0000-0002-5081-6273 [email protected] Sabzevar University of Medical Sciences View all articles by this author Metrics & Citations Metrics Article Usage 172 views 83 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Mehdi Jalili Akbarian, Mahta Mohtashami, Morteza Rasti Sani, et al. Association between Serum Vitamin D Levels and Respiratory Infections in Hospitalized Children: A Case-Control Study. Authorea . 17 February 2025. DOI: https://doi.org/10.22541/au.173976484.42666183/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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