Case report: The case of a 17 kg ovarian granulosa cell tumor in a Breton draft mare

Munkhtuul Tsogtgerel, Masaaki Tagami, Kenichi Watanabe, Harutaka MURASE, Yuko HIROSAWA, Yoshiyasu KOBAYASHI, Yasuo NAMBO
In: Journal of Equine Science · 2021 · vol. 32(2) , pp. 67–72 · doi:10.1294/jes.32.67 · PMID:34220274 · W3175056350
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Abstract

Granulosa cell tumor (GCT) is a benign tumor which affects the mare's ovaries. In this report, a case of unilateral GCT in an ovary, which weighed 17.04 kg, of a 9-year-old Breton draft mare is described. A transrectal ultrasonography exam revealed a unilateral multi-cystic enlarged ovary. Laparoscopic ovariectomy was difficult due to enlargement of blood vessels in the ovarian broad ligament. The mare was necropsied, and the pathological changes in the GCT-affected ovary and unaffected ovary were evaluated. The ovarian mass in the GCT-affected ovary had a cribriform pattern and was positive for anti-Müllerian hormone (AMH) and its receptor (AMHR2). The contralateral ovary showed no follicular development and was negative for AMH. AMHR2 was positively expressed in stromal cells. The AMH concentration in plasma was 4,210 ng/ml. This is the first report showing the presence of AMH (2,210 ng/ml) in ascites fluid, and it also shows that laparoscopic ovariectomy might not be suitable for larger ovaries affected by a GCT. Ultrasonographic, endocrine, and histopathological analyses were helpful for making a definitive diagnosis of GCT in this mare.

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