Clinical analysis of bloodstream infection of Escherichia coli in patients with pancreatic cancer

Clinical analysis of bloodstream infection of Escherichia coli in patients with pancreatic cancer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Clinical analysis of bloodstream infection of Escherichia coli in patients with pancreatic cancer Changsen Bai, Xiuse Zhang, Dong Yang, Ding Li, Wenfang Zhang, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.19350/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background To study the common pathogens and cancer types of bloodstream infection (BSI) in cancer patients, find the risk factors and conduct clinical analysis. Methods The clinical data of 2302 patients with BSI in Tianjin Medical University Cancer Institute and Hospital (TMUCIH) from January 2011 to December 2018 were retrospectively analyzed. 31 pancreatic cancer patients complicated with Escherichia coli BSI and 93 pancreatic cancer patients without BSI at the same period with similar sex and age were divided into infection group and non-infection group. Results 645 strains (28%) of Escherichia coli were the main pathogens causing BSI in patients with cancer. 57 cases (8.8%) of cancer patients with Escherichia coli BSI were from pancreatic oncology department, among which 31 cases were diagnosed as pancreatic cancer by pathology. Multivariate logistic regression analysis showed that hospitalization days≥7, chemotherapy and neutrophil>5.5×10 9 /L were independent risk factors for pancreatic cancer patients complicated with BSI (P < 0.05). Quantitative analysis of serum-related indicators in infection patients and non-infection patients showed significant differences between albumin, prealbumin and neutrophils in infection and non-infection group. The ratio of Escherichia coli producing extended-spectrum ß-lactamase is 49.3 and 48.1 in pancreatic cancer and non-pancreatic patients. Escherichia coli resistant to carbapenems is rare, they were highly sensitive to Cephamycin and Piperacillin/tazobactam. Conclusions Escherichia coli, the main pathogen causing BSI of cancer patients, is more common in pancreatic cancer patients. The independent risk factors include hospitalization days≥7 days, chemotherapy and neutrophils larger than 5.5×10 9 /L. Quantitative indicators of neutrophil counts, albumin and prealbumin contribute to the early diagnosis of bloodstream infections. Early use of medication, while timely adjustment based on clinical drug sensitivity results will help reduce patient morbidity and mortality. General Microbiology Pancreatic cancer Escherichia coli BSI Clinical analysis risk factor Figures Figure 1 Background Bloodstream infection(BSI) has a high mortality rate and is costly, it is the most difficult type of infection to control, and has a great impact on the prognosis of patients(1, 2). Due to improper use of antibiotics, the resistance of pathogenic bacteria to commonly used antibacterial drugs is increasing(3, 4), coupled with the adverse reactions caused by the abuse of antibiotics(5, 6), has made the treatment of bloodstream infection difficult. In patients with malignant tumors, due to integrity damage (surgery, trauma, indwelling catheters) and some medical sources (antibiotic use, radiotherapy and chemotherapy) and non-medical factors (advanced age, poor nutritional status), the body's immunity is reduced or immune dysfunction, it is easily to induce various infections(7–11). There are differences in the distribution and drug resistance of pathogens in BSIs in different cancer patients(12–16). We analyzed BSIs data of Tianjin Medical University Cancer Institute and Hospital (TMUCIH) for eight years and found that the most common pathogen of bloodstream infection in cancer patients is Escherichia coli(E. coli), and the most common oncology department is pancreatic oncology. E. coli is the main cause of BSI involving Gram-negative bacteria(17, 18). The last 20 years have witnessed a striking increase of BSI caused by antibiotic-resistant strains of E. coli(19, 20). Studies have shown that failure to provide timely and effective antibacterial therapy for BSI caused by extended-spectrum-lacta-mases (ESBL)-producing Escherichia coli is associated with increased mortality(19–22). Pancreatic cancer is a malignant tumor of the digestive tract with high malignancy and difficulty in diagnosis and treatment(23–25). Its mortality has decreased by significant advances in preoperative evaluation, surgical techniques, and postoperative care in recent years, postoperative adjuvant chemotherapy such as radiotherapy and chemotherapy can improve the survival rate, however, the 5-year survival rate is only around 5%, which is still one of the worst prognostic malignancies(23, 26–28). Early diagnosis and treatment are the key to improve the prognosis of pancreatic cancer(29, 30). There are 2,600 beds in TMUCIH, more than 80 beds in the hepatobiliary and gastrointestinal oncology departments, and only 30 beds in the pancreatic oncology department, but the proportion of Escherichia coli BSI was the highest, of which the cause remains to be determined. Further analyze the risk factors can provide assistance for the diagnosis and treatment of pancreatic cancer patients with BSI. For a variety of reasons, patients with solid tumors are particularly predisposed to develop BSI, however, little information is currently available, let alone pancreatic cancer. Therefore, our data is precious and can provide valuable experience. 1. Materials and methods 1.1 Patients and study design Our study analyzed 2302 blood culture positive pathogens of cancer patients from January 2011 to December 2018 in TMUCIH (Exclude duplicate strains isolated from the same patient within two weeks). The first ranked pathogen was Escherichia coli (645 cases). The main cancer patients with Escherichia coli BSI were from pancreatic cancer oncology (57 cases). 31 patients diagnosed with pancreatic cancer by pathologist were defined as the infection group, and 93 pancreatic cancer patients with similar sex and age of were collected as non-infection group. The clinical data of 31 pancreatic cancer patients infected with Escherichia coli BSI and 93 pancreatic cancer patients without BSI were retrospectively analyzed by case-control study. The clinical data included gender, age, and the number hospitalization of days, the number of hospitalizations, surgery, bleeding during surgery, blood transfusion, radiotherapy and chemotherapy, the type of antibiotics used, distant organ metastasis of cancer, invasive operation (retention drainage tube, central venous catheter or urine tube), stayed in ICU, white blood cells, neutrophils, CRP, PCT, albumin, prealbumin counts, merger with other parts of infection and diabetes were collected. 1.2 Ethics statement This study was approved by the Research Ethics Committee of TMUCIH. All patients signed informed consent. 1.3 Definition When there was an unexplained fever and suspected to be a BSI, doctors would send at least one set of blood culture and promptly sent for inspection. Blood samples (8-10 mL) were collected and auto-cultured by BACTEC 9050, 9120, or FX400 (Becton Dickinson, Franklin Lakes, NJ, USA) for 5 days. Positive samples were subcultured on blood agar (Jin Zhang Ke Ji, Tianjin, China) at 35°C for 24-48 hours depending on the results of gram staining. Species identification and bacterial susceptibility tests were performed on a VITEK 2 compact automatic microbiological analysis system (bio-Merieux SA, Marcy l’Etoile, France). All coincidence rates were above 95%. 1.4 Quality control The quality control strains were Enterobacter cloacae 700323, Escherichia coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. 1.5 Statistical analysis Bacterial resistance analysis, pathogen and departmental distribution was performed by Whonet 5.6 software. SPSS 17.0 was adopted to do univariate and multivariate analysis. Data of categorical variables were compared by Fisher’s exact test, P<0.1 was a potential risk factor. The risk factors were included in the multivariate logistic regression model to analyze the independent risk factors, P<0.05 indicates statistical significance. All tests were two-tailed. Graphpad Prism 7.0 was used to analyze quantitative data differences. 2. results 2.1 Distribution of pathogenic bacteria in BSI of cancer patients In 2011-2018, 2700 strains of pathogens were detected in 2302 blood culture-positive specimens. The main pathogen causing BSI was Escherichia coli , 645, accounting for 28%. The distribution of pathogens is shown in Table 1. Table 1 The ratio of pathogens in cancer patients complicated with BSI 2.2 Departmental distribution of cancer patients complicated with Escherichia coli BSI The BSI caused by Escherichia coli was distributed in different departments of TMUCIH. The main cancer patients causing Escherichia coli BSI were pancreatic cancer oncology patients (57 cases, 8.8%). The distribution of tumor types is shown in Table 2. Table 2 Departmental distribution of cancer patients complicated with Escherichia coli BSI 2.3 Analysis of risk factors for BSI of patients with pancreatic cancer complicated with Escherichia coli Analysis of clinical data of 31 infected patients and 93 control patients showed that hospitalization days, number of admissions≥2 times, previous exposure to antibiotics≥2 species, chemotherapy, white blood cells >7.4×10 9 /L, neutrophil>5.5×10 9 /L, PCT>2.2 μg/L, albumin<36.0 g/L were potential risk factors for pancreatic cancer patients with Escherichia coli BSI (P < 0.1), see Table 3. Table 3 Analysis of risk factors for Escherichia coli BSI in patients with pancreatic cancer 2.4 Multivariate logistic regression analysis of Escherichia coli BSI in patients with pancreatic cancer Incorporate potential risk factors into the multivariate logistic regression model. The results showed that hospitalization days≥7 days, chemotherapy, and neutrophils>5.5 ×10 9 /L were independent risk factors for Escherichia coli BSI in patients with pancreatic cancer. See Table 4. Table 4 Multivariate logistic regression analysis of Escherichia coli BSI in patients with pancreatic cancer 2.5 Quantitative analysis of serum related indicators of Escherichia coli BSI in patients with pancreatic cancer Quantitative analysis of serum-related indicators included neutrophils, C-reactive protein (CRP), procalcitonin (PCT), albumin and prealbumin showed the neutrophils in the infection group were significantly higher than those in the non-infection group. Albumin and prealbumin in the infection group were much lower than in the non-infection group, see figure 1. Figure1 Quantitative analysis of serum related indicators of Escherichia coli BSI in patients with pancreatic cancer A:Leukocyte and B: Neutrophil in the blood of infection and non-infection groups were compared, C:CRP, D: PCT, E: Albumin, and F: Prealbumin in the serum of infection and non-infection groups were compared. 2.6 Analysis of drug resistance of pancreatic cancer patients complicated with Escherichia coli BSI There was no significant difference in the resistance rates of antibiotics between Escherichia coli BSI of pancreatic cancer and non-pancreatic patients. The ratio of Escherichia coli producing extended-spectrum ß-lactamase is 49.3 and 48.1 respectively. Escherichia coli resistant to carbapenems is rare, they were highly sensitive to Cephamycin and Piperacillin/tazobactam. Table 5 Analysis of drug resistance of Escherichia coli BSI in pancreatic cancer and non-pancreatic patients 3. discussion BSI refers to the invasion of various pathogenic microorganisms (bacteria or fungi) into the bloodstream and is one of the serious systemic infectious diseases( 31 ). During the next two decades, the percentage of Gram-positive bacteria BSI has increased( 32 ), but Gram-negative bacteria still account for about 50%( 33 ), and mainly Escherichia coli( 34 , 35 ). Patients with malignant tumors often require surgery, high-dose chemoradiotherapy, antibiotic use, and various invasive procedures, or the malignancy itself, which tend to increase the chance of Escherichia coli infection( 9 ). Blood culture is the gold standard for the diagnosis of Escherichia coli BSI( 36 ), but its diagnosis takes a long time, which will delay clinical and timely treatment. In addition, the distribution of pathogens and the risk factors for BSI are different due to different diseases and tumor types( 32 , 37 , 38 ). The pancreatic cancer has a high degree of malignancy, a low rate of surgical resection, and a poor prognosis( 39 , 40 ). The occurrence of BSI may further increase the difficulty of treatment. Therefore, clinical analysis of risk factors for Escherichia coli BSI in patients with pancreatic cancer is essential for the prevention of potentially high-risk populations and timely and effective treatment of patients. Our study showed hospitalization days≥7 days, hospitalizations≥2 times, chemotherapy and used two or more antibiotic types, white blood cells, neutrophils, PCT, albumin and pancreatic cancer patients with Escherichia coli BSI was closely related, but multivariate logistic regression analysis showed that only hospital days ≥7 days, chemotherapy, neutrophils were independent risk factors for Escherichia coli BSI. Pancreatic cancer patients have a long-term adjuvant and neoadjuvant treatment, radiation therapy, combined with a variety of serious underlying diseases and multiple surgical treatments( 40-42 ) lead to prolonged hospital stay, and gradually reduce autoimmune function, thus increasing the chance of Escherichia coli BSI. Study have also shown that patients with longer hospital stays are prone to BSI( 43 ). Therefore, the relevant medical staff in the hospital should strictly carry out aseptic operation, regularly disinfect the medical equipment and related wards and departments, and try to shorten the hospitalization time of patients to reduce the incidence of BSI. In the results of this study, 67.7% of pancreatic cancer patients with Escherichia coli BSI received chemotherapy (Adjuvant or/ and neoadjuvant treatment). Neoadjuvant treatment helps to kill cancer cells and reduce the tumor implantation caused by surgery. Adjuvant therapy can effectively improve the treatment effect and reduce recurrence and metastasis. Adjuvant chemotherapy with gemcitabine is standard care for resected pancreatic cancer( 44 ), not only delayed recurrence, but also improved survival compared with surgery alone( 45 ). However, while killing cancer cells, chemotherapy also kills normal immune cells. For instance, the dose-limiting toxicity of gemcitabine is myelosuppression, leading to a decrease in neutrophils and platelets, which reduces the body's immunity. At the same time, chemotherapeutic drugs such as doxorubicin, which can easily damage the intima of the blood vessels( 46 ), leading to partial venous catheterization blockage, causing BSI. Cancer patients often have infections in other sites, and different types of antibiotics are often used for different infection sites( 47 ). Therefore, the use of two or more antibiotic types was a potential risk factor for Escherichia coli BSI. Studies have shown that, surgery is a kind of trauma to the human body, which will cause the patient's resistance to decline, causing BSI( 48 ). In addition, with the rapid development and popularization of medical technology, various implant operations such as drainage tubes, catheters, central venous catheters, etc., not only play a therapeutic role, but also pose a risk to BSI, therefore, implantation was also an important risk factor( 49 ), but the relationship between surgical and invasive procedures in Escherichia coli BSI was not significant (P>0.05) in our study. Besides, blood culture diagnosis of pathogens takes a long time and may delay the treatment of the disease. So the other measured clinical indicators can provide timely help for clinical diagnosis and treatment. Studies have also showed the use of white blood cells, neutrophils, CRP, PCT as a reliable indicator of early diagnosis of BSI( 50-53 ). Our study showed that neutrophils>5.5×10 9 /L was independent risk factor for Escherichia coli BSI (P<0.05). Neutrophils are the most abundant white blood cells, accounting for 50%-70% of the total white blood cells, they are the first barrier of the body's defense. When inflammation occurs, neutrophils will penetrate the vascular endothelium then enter the site of inflammation to exert a bactericidal effect. Therefore, neutrophils were significantly increased in the presence of BSI. The total number of white blood cells >7.4×10 9 /L was not significantly correlated with Escherichia coli BSI (P>0.05). This may be due to patients with pancreatic cancer suffer from frequent chemoradiotherapy, which inhibits bone marrow function( 41 , 44 ), resulting in a decrease in the total number of white blood cells. CRP is a non-specific acute phase response protein that is on the rise in early infection( 52 ). There was no significant difference between CRP and Escherichia coli BSI in this study. Studies have pointed out that PCT is very low in normal humans, but when bacterial infection occurs, PCT levels increase significantly, which is an effective indicator of whether it is a bacterial infection( 53 ). Therefore, the specificity of PCT is higher than that of CRP, but the sensitivity is lower than that of CRP. As shown herein, PCT is a potential risk factor for Escherichia coli BSI. Albumin and prealbumin can be used as monitoring indicators of nutrients in the body. When the nutritional status of patients is poor, the immune function of the body decreases, and albumin and prealbumin decrease accordingly( 54 ). In the quantitative analysis, albumin and prealbumin in the infection group were significantly lower than those in the non-infection group, indicating that patients with pancreatic cancer were prone to Escherichia coli BSI when their nutritional status is poor. This study clearly confirmed the relationship between nutritional status and bloodstream infection in patients with pancreatic cancer. In our study, the proportion of ESBL produced by Escherichia coli was about 50%, which was lower than that reported in other studies( 55 , 56 ). The resistance rate of ceftriaxone was significantly higher than that of ceftazidime, which may be related to the main cefotaxime (CTX) type of ESBL in this region. Carbapenems, Cephamycin and Piperacillin/tazobactam can be used as the first choice for empirical use, but doctors should adjust the drug according to the drug susceptibility results of clinical microbiology to reduce the occurrence of special and restricted antibiotic resistance. However, this study also has some limitations. Although the data of eight-year pancreatic cancer patients with Escherichia coli BSI were collected, the number of cases is still small. It is a single-center study, which can be combined for pancreatic cancer in North China. The diagnosis and treatment of pancreatic cancer patients with Escherichia coli BSI need further multi-center research to promote its application. Conclusions Escherichia coli, the main pathogen causing BSI of cancer patients, is more common in pancreatic cancer patients. The independent risk factors include hospitalization days , chemotherapy and neutrophils larger than 5.5×10 9 /L. Therefore, patients with suspected BSI should be promptly drawn for blood culture. At the same time, clinical tests should be combined with laboratory tests such as neutrophils, albumin and prealbumin to make early diagnosis. Early use of medication, while timely adjustment based on clinical drug sensitivity results, will help reduce patient morbidity and mortality. declarations Ethics approval and consent to participate: This study was approved by the Research Ethics Committee of TMUCIH. All patients signed informed consent. Availability of data and materials : The data that support the findings of this study are available from the archives of the TMUCIH but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request to the corresponding author (Li Ren and Yueguo Li) and with permission of the TMUCIH. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. Funding: This work was supported by Grants 81871719 and 81802080 from Natural Science Foundation of China, Tianjin Medical University Cancer Institute and Hospital Grants Y1702, Y1711, Y1713. Authors' contributions: Changsen Bai designed the study and wrote the manuscript, Xiuse Zhang and Dong Yang collected the clinical data, Ding Li, Wenfang Zhang, Yunli Zhou, Qing Zhang and Shan Zheng did the bacterial identification and drug susceptibility experiments, Li Ren and Yueguo Li guided data analysis, manuscript writing and revision. Acknowledgements: Thanks to the Natural Science Foundation of China, Tianjin Medical University Cancer Institute and Hospital Grants Y1702, Y1711, Y1713 for funding this research. references Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. The New England journal of medicine. 2003;348(16):1546-54. Tumbarello M, Viale P, Viscoli C, Trecarichi EM, Tumietto F, Marchese A, et al. Predictors of Mortality in Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Importance of Combination Therapy. Clin Infect Dis. 2012;55(7):943-50. 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The Journal of antimicrobial chemotherapy. 2018;73(3):634-42. tables Table 1 The ratio of pathogens in cancer patients complicated with BSI Pathogen species Number of strains Number of patients Composition ratio（%） Escherichia coli 776 645 28.0 Coagulase-negative staphylococci 435 388 16.9 Klebsiella pneumoniae 349 310 13.5 Staphylococcus aureus 137 110 4.8 Enterobacter cloacae 104 88 3.8 Enterococcus faecalis 99 86 3.7 Pseudomonas aeruginosa 97 84 3.6 Enterococcus faecium 89 63 2.7 Candida albicans 76 48 2.1 Other pathogens 538 480 20.9 Total 2700 2302 100.0 Table 2 Departmental distribution of cancer patients complicated with Escherichia coli BSI Department Number of strains Number of patients Composition ratio（%） Pancreatic Oncology 69 57 8.8 Hepatobiliary Oncology 66 55 8.5 Integrated Traditional Chinese and Western Medicine Oncology 59 47 7.3 Interventional Therapy Oncology 56 47 7.3 Intensive care and treatment Oncology 47 27 4.2 Hematology oncology 43 42 6.5 Digestive Oncology 39 35 5.4 Biotherapy Oncology 37 27 4.2 Radiation Oncology 36 22 3.4 Gynecologic Oncology 34 28 4.3 Other oncology 290 258 40.0 Total 776 645 100.0 Table 3 Analysis of risk factors for Escherichia coli BSI in patients with pancreatic cancer Risk factor Infection group （ n=31 ） Control group （ n=93 ） Number of cases Composition ratio （ % ） Number of cases Composition ratio （ % ） Sex（Male) 18 58.1 51 54.8 Age ≥ 60 years old 15 48.3 56 60.2 Hospitalization days ≥7 days 17 54.8 11 11.8 Number of admissions≥2 times 30 96.8 79 84.9 Surgery 18 58.1 42 45.2 Intraoperative bleeding 6 19.4 22 23.7 Chemotherapy 21 67.7 46 49.5 Previous exposure to antibiotics≥ 2 species 9 29 12 12.9 Distant organ metastasis of cancer 16 51.6 35 37.6 Drainage tube 12 38.7 32 34.4 Merger with other parts of infection 6 19.4 16 17.2 Stayed in ICU 5 16.1 8 8.6 Blood transfusion 5 16.1 18 19.4 Combined with diabetes 5 16.1 25 26.9 White blood cells>7.4×10 9 /L 15 40.5 27 29 Neutrophil>5.5×10 9 /L 20 64.5 18 19.4 CRP>31.8 mg/L 4 12.9 11 11.8 PCT>2.2 μg/L 6 19.4 6 6.5 Albumin<36.0 g/L 14 45.2 26 28 Prealbumin<0.14 g/L 14 45.2 32 34.4 Table 4 Multivariate logistic regression analysis of Escherichia coli BSI in patients with pancreatic cancer Risk factor B Waldχ 2 OR=Exp(B) p value 95%CI Hospitalization days ≥7 days 2.64 17.143 12.039 ＜0.001 3.200-45.286 Number of admissions≥2 times 1.435 0.813 4.201 0.367 0.186-95.063 Chemotherapy 1.901 8.698 6.691 0.003 1.368-20.561 Previous exposure to antibiotics≥ 2 species 1.486 3.602 4.42 0.058 0.777-18.613 White blood cells>7.4×10 9 /L -1.807 2.021 0.164 0.155 0.016-2.618 Neutrophil>5.5×10 9 /L 2.698 19.105 14.853 ＜0.001 4.430-49.804 PCT>2.2 μg/L 1.066 0.717 2.903 0.397 0.246-34.248 Table 5 Analysis of drug resistance of Escherichia coli BSI in pancreatic cancer and non-pancreatic patients Antibiotic Non-pancreatic cancer(n=750) pancreatic cancer(n=31) p value ESBL 48.1 49.3 0.896 Ampicillin 80.6 82.6 0.782 Piperacillin 61.6 60.9 0.937 Ampicillin/sulbactam 45.1 52.2 0.437 Piperacillin/tazobactam 2.6 2.9 0.918 Cefazolin 51.4 55.1 0.686 Cefuroxime 50.3 49.3 0.913 Ceftazidime 20.8 23.2 0.695 Ceftriaxone 49.7 50.7 0.913 Cefepime 12.8 15.9 0.614 Cefotetan 2.1 1.4 0.789 Aztreonam 30.1 30.4 0.972 Imipenem 0.2 0 0.803 Meropenem 0.2 0 0.803 Amikacin 0.9 2.9 0.268 Gentamicin 48.8 39.1 0.283 Tobramycin 10.8 10.1 0.902 Ciprofloxacin 51 39.1 0.194 Levofloxacin 48.1 37.7 0.256 Sulfamethoxazole 60.1 56.5 0.689 Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Bai","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2ElEQVRIiWNgGAWjYDACCShtwMDY+CChooY0Lc0GD84cI0kLA5vkwxZmwjr4Zzc/e/jlj02eOfvhtorEBjYG/vbuBPyW3DlmbizbllZs2ZPYdiNxhwyDxJmzG/BqMZBIMJOWbDicuOEASMsZNqBILiEt6d+kJf78T9xw/mFbQWIbMzFacswkP7AdSNxwI7GNgSgtEjdyyqQZ25ITd8542CyRcOYYD0G/8M9I3yb5449d4nb+9Icff1TUyPG39+LXAgLMPEgcHpzKkAHjD6KUjYJRMApGwYgFAG01TN1I2ASfAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-8318-679X","institution":"Tianjin Tumor Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Changsen","middleName":"","lastName":"Bai","suffix":""},{"id":262600,"identity":"72d11f63-1ee8-4358-b971-152f81129821","order_by":2,"name":"Xiuse Zhang","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiuse","middleName":"","lastName":"Zhang","suffix":""},{"id":262601,"identity":"bed86381-308c-49fb-b161-2185dfb09293","order_by":3,"name":"Dong Yang","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dong","middleName":"","lastName":"Yang","suffix":""},{"id":262602,"identity":"f75e48cd-73fe-44ed-9156-3eed9fc1c3c3","order_by":4,"name":"Ding Li","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ding","middleName":"","lastName":"Li","suffix":""},{"id":262603,"identity":"65ab2030-97e3-463e-b85b-38762be4278a","order_by":5,"name":"Wenfang Zhang","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Wenfang","middleName":"","lastName":"Zhang","suffix":""},{"id":262604,"identity":"3ca15d12-4722-4f91-bfb7-46bb06b905a6","order_by":6,"name":"Yunli Zhou","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yunli","middleName":"","lastName":"Zhou","suffix":""},{"id":262605,"identity":"9412da54-6e2c-46f4-ba3e-f3c5600ed02c","order_by":7,"name":"Qing Zhang","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qing","middleName":"","lastName":"Zhang","suffix":""},{"id":262606,"identity":"f4dd8176-bb72-416e-8b9f-f0252a83ed01","order_by":8,"name":"Shan Zheng","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shan","middleName":"","lastName":"Zheng","suffix":""},{"id":262607,"identity":"a264260a-5716-4b7b-8076-34ddd6ff06f0","order_by":9,"name":"Li Ren","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Li","middleName":"","lastName":"Ren","suffix":""},{"id":262608,"identity":"da497c9d-ab5a-447e-95bf-61e51f378798","order_by":10,"name":"Yueguo Li","email":"","orcid":"","institution":"Tianjin Tumor Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yueguo","middleName":"","lastName":"Li","suffix":""}],"badges":[],"createdAt":"2019-12-19 11:15:22","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.19350/v1","doiUrl":"https://doi.org/10.21203/rs.2.19350/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":288629,"identity":"3fbe407a-f31f-4840-aff6-0af80e70dbd6","added_by":"auto","created_at":"2019-12-20 16:04:44","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":59893,"visible":true,"origin":"","legend":"Quantitative analysis of serum related indicators of Escherichia coli BSI in patients with pancreatic cancer A:Leukocyte and B: Neutrophil in the blood of infection and non-infection groups were compared, C:CRP, D: PCT, E: Albumin, and F: Prealbumin in the serum of infection and non-infection groups were compared.","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/99e69f80-0573-4685-b383-5811ff501a24/v1/1.jpg"},{"id":13483182,"identity":"20aafda6-0696-4774-9181-1c9afe5c9891","added_by":"auto","created_at":"2021-09-16 21:52:28","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":565241,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9963/v1/4a777222-a5b3-4b77-b40f-97e0c66c7cf3.pdf"}],"financialInterests":"","formattedTitle":"Clinical analysis of bloodstream infection of Escherichia coli in patients with pancreatic cancer","fulltext":[{"header":"Background","content":" \u003cp\u003eBloodstream infection(BSI) has a high mortality rate and is costly, it is the most difficult type of infection to control, and has a great impact on the prognosis of patients(1, 2). Due to improper use of antibiotics, the resistance of pathogenic bacteria to commonly used antibacterial drugs is increasing(3, 4), coupled with the adverse reactions caused by the abuse of antibiotics(5, 6), has made the treatment of bloodstream infection difficult.\u003c/p\u003e \u003cp\u003eIn patients with malignant tumors, due to integrity damage (surgery, trauma, indwelling catheters) and some medical sources (antibiotic use, radiotherapy and chemotherapy) and non-medical factors (advanced age, poor nutritional status), the body's immunity is reduced or immune dysfunction, it is easily to induce various infections(7\u0026ndash;11).\u003c/p\u003e \u003cp\u003eThere are differences in the distribution and drug resistance of pathogens in BSIs in different cancer patients(12\u0026ndash;16). We analyzed BSIs data of Tianjin Medical University Cancer Institute and Hospital (TMUCIH) for eight years and found that the most common pathogen of bloodstream infection in cancer patients is Escherichia coli(E. coli), and the most common oncology department is pancreatic oncology.\u003c/p\u003e \u003cp\u003eE. coli is the main cause of BSI involving Gram-negative bacteria(17, 18). The last 20\u0026nbsp;years have witnessed a striking increase of BSI caused by antibiotic-resistant strains of E. coli(19, 20). Studies have shown that failure to provide timely and effective antibacterial therapy for BSI caused by extended-spectrum-lacta-mases (ESBL)-producing Escherichia coli is associated with increased mortality(19\u0026ndash;22).\u003c/p\u003e \u003cp\u003ePancreatic cancer is a malignant tumor of the digestive tract with high malignancy and difficulty in diagnosis and treatment(23\u0026ndash;25). Its mortality has decreased by significant advances in preoperative evaluation, surgical techniques, and postoperative care in recent years, postoperative adjuvant chemotherapy such as radiotherapy and chemotherapy can improve the survival rate, however, the 5-year survival rate is only around 5%, which is still one of the worst prognostic malignancies(23, 26\u0026ndash;28). Early diagnosis and treatment are the key to improve the prognosis of pancreatic cancer(29, 30).\u003c/p\u003e \u003cp\u003eThere are 2,600 beds in TMUCIH, more than 80 beds in the hepatobiliary and gastrointestinal oncology departments, and only 30 beds in the pancreatic oncology department, but the proportion of Escherichia coli BSI was the highest, of which the cause remains to be determined. Further analyze the risk factors can provide assistance for the diagnosis and treatment of pancreatic cancer patients with BSI. For a variety of reasons, patients with solid tumors are particularly predisposed to develop BSI, however, little information is currently available, let alone pancreatic cancer. Therefore, our data is precious and can provide valuable experience.\u003c/p\u003e "},{"header":"1. Materials and methods","content":"\u003cp\u003e\u003cem\u003e1.1 \u003c/em\u003e\u003cem\u003ePatients and study design\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003ca name=\"_Toc7215295\"\u003e\u003c/a\u003e\u003ca name=\"_Toc7214851\"\u003e\u003c/a\u003eOur study analyzed 2302 blood culture positive pathogens of cancer patients from January 2011 to December 2018 in TMUCIH (Exclude duplicate strains isolated from the same patient within two weeks). The first ranked pathogen was Escherichia coli (645 cases). The main cancer patients with Escherichia coli BSI were from pancreatic cancer oncology (57 cases). 31 patients diagnosed with pancreatic cancer by pathologist were defined as the infection group, and 93 pancreatic cancer patients with similar sex and age of were collected as non-infection group.\u003c/p\u003e\n\u003cp\u003eThe clinical data of 31 pancreatic cancer patients infected with Escherichia coli BSI and 93 pancreatic cancer patients without BSI were retrospectively analyzed by case-control study. The clinical data included gender, age, and the number hospitalization of days, the number of hospitalizations, surgery, bleeding during surgery, blood transfusion, radiotherapy and chemotherapy, the type of antibiotics used, distant organ metastasis of cancer, invasive operation (retention drainage tube, central venous catheter or urine tube), stayed in ICU, white blood cells, neutrophils, CRP, PCT, albumin, prealbumin counts, merger with other parts of infection and diabetes were collected.\u003c/p\u003e\n\u003cp\u003e\u003ca name=\"_Toc7215297\"\u003e\u003c/a\u003e\u003cem\u003e1.2 Ethics statement\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Research Ethics Committee of TMUCIH. All patients signed informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e1.3 Definition\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003ca name=\"_Toc7215299\"\u003e\u003c/a\u003eWhen there was an unexplained fever and suspected to be a BSI, doctors would send at least one set of blood culture and promptly sent for inspection. Blood samples (8-10 mL) were collected and auto-cultured by BACTEC 9050, 9120, or FX400 (Becton Dickinson, Franklin Lakes, NJ, USA) for 5 days. Positive samples were subcultured on blood agar (Jin Zhang Ke Ji, Tianjin, China) at 35\u0026deg;C for 24-48 hours depending on the results of gram staining. Species identification and bacterial susceptibility tests were performed on a VITEK 2 compact automatic microbiological analysis system (bio-Merieux SA, Marcy l\u0026rsquo;Etoile, France). All coincidence rates were above 95%.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e1.4 Quality control \u003ca name=\"_Toc7215300\"\u003e\u003c/a\u003e\u003ca name=\"_Toc7214852\"\u003e\u003c/a\u003e\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe quality control strains were Enterobacter cloacae 700323, Escherichia coli ATCC25922 and Pseudomonas aeruginosa ATCC27853.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e1.5 Statistical analysis\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eBacterial resistance analysis, pathogen and departmental distribution was performed by Whonet 5.6 software. SPSS 17.0 was adopted to do univariate and multivariate analysis. Data of categorical variables were compared by Fisher\u0026rsquo;s exact test, P\u0026lt;0.1 was a potential risk factor. The risk factors were included in the multivariate logistic regression model to analyze the independent risk factors, P\u0026lt;0.05 indicates statistical significance. All tests were two-tailed. Graphpad Prism 7.0 was used to analyze quantitative data differences.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e"},{"header":"2. results","content":"\u003cp\u003e\u003cem\u003e2.1\u0026nbsp; Distribution of pathogenic bacteria in BSI of cancer patients\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eIn 2011-2018, 2700 strains of pathogens were detected in 2302 blood culture-positive specimens. The main pathogen causing BSI was Escherichia coli , 645, accounting for 28%. The distribution of pathogens is shown in Table 1. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1\u0026nbsp; The ratio of pathogens in cancer patients complicated with BSI\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e2.2 Departmental distribution of cancer patients complicated with Escherichia coli BSI\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe BSI caused by Escherichia coli was distributed in different departments of TMUCIH. The main cancer patients causing Escherichia coli BSI were pancreatic cancer oncology patients (57 cases, 8.8%). The distribution of tumor types is shown in Table 2.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2 Departmental distribution of cancer patients complicated with Escherichia coli BSI\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e2.3 Analysis of risk factors for BSI of patients with pancreatic cancer complicated with Escherichia coli\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eAnalysis of clinical data of 31 infected patients and 93 control patients showed that hospitalization days, number of admissions\u0026ge;2 times, previous exposure to antibiotics\u0026ge;2 species, chemotherapy, white blood cells \u0026gt;7.4\u0026times;10\u003csup\u003e9\u003c/sup\u003e /L, neutrophil\u0026gt;5.5\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L, PCT\u0026gt;2.2 \u0026mu;g/L, albumin\u0026lt;36.0 g/L were potential risk factors for pancreatic cancer patients with Escherichia coli BSI (P \u0026lt; 0.1), see Table 3.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3 Analysis of risk factors for Escherichia coli BSI in patients with pancreatic cancer\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e2.4 Multivariate logistic regression analysis of Escherichia coli BSI in patients with pancreatic cancer\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eIncorporate potential risk factors into the multivariate logistic regression model. The results showed that hospitalization days\u0026ge;7 days, chemotherapy, and neutrophils\u0026gt;5.5\u003c/p\u003e\n\u003cp\u003e\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L were independent risk factors for Escherichia coli BSI in patients with pancreatic cancer. See Table 4.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 4 Multivariate logistic regression analysis of Escherichia coli BSI in patients with pancreatic cancer\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e2.5 Quantitative analysis of serum related indicators of Escherichia coli BSI in patients with pancreatic cancer\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eQuantitative analysis of serum-related indicators included neutrophils, C-reactive protein (CRP), procalcitonin (PCT), albumin and prealbumin showed the neutrophils in the infection group were significantly higher than those in the non-infection group. Albumin and prealbumin in the infection group were much lower than in the non-infection group, see figure 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFigure1 Quantitative analysis of serum related indicators of Escherichia coli BSI in patients with pancreatic cancer \u0026nbsp;\u003c/strong\u003eA:Leukocyte and B: Neutrophil in the blood of infection and non-infection groups were compared, \u0026nbsp;C:CRP, D: PCT, E: Albumin, and F: Prealbumin in the serum of infection and non-infection groups were compared.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e2.6 Analysis of drug resistance of pancreatic cancer patients complicated with Escherichia coli BSI \u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThere was no significant difference in the resistance rates of antibiotics between Escherichia coli BSI of pancreatic cancer and non-pancreatic patients. The ratio of Escherichia coli producing extended-spectrum \u0026szlig;-lactamase is 49.3 and 48.1 respectively. Escherichia coli resistant to carbapenems is rare, they were highly sensitive to Cephamycin and Piperacillin/tazobactam.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 5 Analysis of drug resistance of Escherichia coli BSI in pancreatic cancer and non-pancreatic\u003c/strong\u003e \u003cstrong\u003epatients \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"3. discussion ","content":"\u003cp\u003eBSI refers to the invasion of various pathogenic microorganisms (bacteria or fungi) into the bloodstream and is one of the serious systemic infectious diseases(\u003ca href=\"#_ENREF_31\"\u003e31\u003c/a\u003e). During the next two decades, the percentage of Gram-positive bacteria BSI has increased(\u003ca href=\"#_ENREF_32\"\u003e32\u003c/a\u003e), but Gram-negative bacteria still account for about 50%(\u003ca href=\"#_ENREF_33\"\u003e33\u003c/a\u003e), and mainly Escherichia coli(\u003ca href=\"#_ENREF_34\"\u003e34\u003c/a\u003e, \u003ca href=\"#_ENREF_35\"\u003e35\u003c/a\u003e). Patients with malignant tumors often require surgery, high-dose chemoradiotherapy, antibiotic use, and various invasive procedures, or the malignancy itself, which tend to increase the chance of Escherichia coli infection(\u003ca href=\"#_ENREF_9\"\u003e9\u003c/a\u003e). Blood culture is the gold standard for the diagnosis of Escherichia coli BSI(\u003ca href=\"#_ENREF_36\"\u003e36\u003c/a\u003e), but its diagnosis takes a long time, which will delay clinical and timely treatment. In addition, the distribution of pathogens and the risk factors for BSI are different due to different diseases and tumor types(\u003ca href=\"#_ENREF_32\"\u003e32\u003c/a\u003e, \u003ca href=\"#_ENREF_37\"\u003e37\u003c/a\u003e, \u003ca href=\"#_ENREF_38\"\u003e38\u003c/a\u003e). The pancreatic cancer has a high degree of malignancy, a low rate of surgical resection, and a poor prognosis(\u003ca href=\"#_ENREF_39\"\u003e39\u003c/a\u003e, \u003ca href=\"#_ENREF_40\"\u003e40\u003c/a\u003e). The occurrence of BSI may further increase the difficulty of treatment. Therefore, clinical analysis of risk factors for Escherichia coli BSI in patients with pancreatic cancer is essential for the prevention of potentially high-risk populations and timely and effective treatment of patients.\u003c/p\u003e\n\u003cp\u003eOur study showed hospitalization days\u0026ge;7 days, hospitalizations\u0026ge;2 times, chemotherapy and used two or more antibiotic types, white blood cells, neutrophils, PCT, albumin and pancreatic cancer patients with Escherichia coli BSI was closely related, but multivariate logistic regression analysis showed that only hospital days \u0026ge;7 days, chemotherapy, neutrophils were independent risk factors for Escherichia coli BSI. Pancreatic cancer patients have a long-term adjuvant and neoadjuvant treatment, radiation therapy, combined with a variety of serious underlying diseases and multiple surgical treatments(\u003ca href=\"#_ENREF_40\"\u003e40-42\u003c/a\u003e) lead to prolonged hospital stay, and gradually reduce autoimmune function, thus increasing the chance of Escherichia coli BSI. Study have also shown that patients with longer hospital stays are prone to BSI(\u003ca href=\"#_ENREF_43\"\u003e43\u003c/a\u003e). Therefore, the relevant medical staff in the hospital should strictly carry out aseptic operation, regularly disinfect the medical equipment and related wards and departments, and try to shorten the hospitalization time of patients to reduce the incidence of BSI.\u003c/p\u003e\n\u003cp\u003eIn the results of this study, 67.7% of pancreatic cancer patients with Escherichia coli BSI received chemotherapy (Adjuvant or/ and neoadjuvant treatment). Neoadjuvant treatment helps to kill cancer cells and reduce the tumor implantation caused by surgery. Adjuvant therapy can effectively improve the treatment effect and reduce recurrence and metastasis. Adjuvant chemotherapy with gemcitabine is standard care for resected pancreatic cancer(\u003ca href=\"#_ENREF_44\"\u003e44\u003c/a\u003e), not only delayed recurrence, but also improved survival compared with surgery alone(\u003ca href=\"#_ENREF_45\"\u003e45\u003c/a\u003e). However, while killing cancer cells, chemotherapy also kills normal immune cells. For instance, the dose-limiting toxicity of gemcitabine is myelosuppression, leading to a decrease in neutrophils and platelets, which reduces the body's immunity. At the same time, chemotherapeutic drugs such as doxorubicin, which can easily damage the intima of the blood vessels(\u003ca href=\"#_ENREF_46\"\u003e46\u003c/a\u003e), leading to partial venous catheterization blockage, causing BSI.\u003c/p\u003e\n\u003cp\u003eCancer patients often have infections in other sites, and different types of antibiotics are often used for different infection sites(\u003ca href=\"#_ENREF_47\"\u003e47\u003c/a\u003e). Therefore, the use of two or more antibiotic types was a potential risk factor for Escherichia coli BSI. Studies have shown that, surgery is a kind of trauma to the human body, which will cause the patient's resistance to decline, causing BSI(\u003ca href=\"#_ENREF_48\"\u003e48\u003c/a\u003e). In addition, with the rapid development and popularization of medical technology, various implant operations such as drainage tubes, catheters, central venous catheters, etc., not only play a therapeutic role, but also pose a risk to BSI, therefore, implantation was also an important risk factor(\u003ca href=\"#_ENREF_49\"\u003e49\u003c/a\u003e), but the relationship between surgical and invasive procedures in Escherichia coli BSI was not significant (P\u0026gt;0.05) in our study.\u003c/p\u003e\n\u003cp\u003eBesides, blood culture diagnosis of pathogens takes a long time and may delay the treatment of the disease. So the other measured clinical indicators can provide timely help for clinical diagnosis and treatment. Studies have also showed the use of white blood cells, neutrophils, CRP, PCT as a reliable indicator of early diagnosis of BSI(\u003ca href=\"#_ENREF_50\"\u003e50-53\u003c/a\u003e). Our study showed that neutrophils\u0026gt;5.5\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L was independent risk factor for Escherichia coli BSI (P\u0026lt;0.05). Neutrophils are the most abundant white blood cells, accounting for 50%-70% of the total white blood cells, they are the first barrier of the body's defense. When inflammation occurs, neutrophils will penetrate the vascular endothelium then enter the site of inflammation to exert a bactericidal effect. Therefore, neutrophils were significantly increased in the presence of BSI. The total number of white blood cells \u0026gt;7.4\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L was not significantly correlated with Escherichia coli BSI (P\u0026gt;0.05). This may be due to patients with pancreatic cancer suffer from frequent chemoradiotherapy, which inhibits bone marrow function(\u003ca href=\"#_ENREF_41\"\u003e41\u003c/a\u003e, \u003ca href=\"#_ENREF_44\"\u003e44\u003c/a\u003e), resulting in a decrease in the total number of white blood cells. CRP is a non-specific acute phase response protein that is on the rise in early infection(\u003ca href=\"#_ENREF_52\"\u003e52\u003c/a\u003e). There was no significant difference between CRP and Escherichia coli BSI in this study. Studies have pointed out that PCT is very low in normal humans, but when bacterial infection occurs, PCT levels increase significantly, which is an effective indicator of whether it is a bacterial infection(\u003ca href=\"#_ENREF_53\"\u003e53\u003c/a\u003e). Therefore, the specificity of PCT is higher than that of CRP, but the sensitivity is lower than that of CRP. \u0026nbsp;As shown herein, PCT is a potential risk factor for Escherichia coli BSI.\u003c/p\u003e\n\u003cp\u003eAlbumin and prealbumin can be used as monitoring indicators of nutrients in the body. When the nutritional status of patients is poor, the immune function of the body decreases, and albumin and prealbumin decrease accordingly(\u003ca href=\"#_ENREF_54\"\u003e54\u003c/a\u003e). In the quantitative analysis, albumin and prealbumin in the infection group were significantly lower than those in the non-infection group, indicating that patients with pancreatic cancer were prone to Escherichia coli BSI when their nutritional status is poor. This study clearly confirmed the relationship between nutritional status and bloodstream infection in patients with pancreatic cancer.\u003c/p\u003e\n\u003cp\u003eIn our study, the proportion of ESBL produced by Escherichia coli was about 50%, which was lower than that reported in other studies(\u003ca href=\"#_ENREF_55\"\u003e55\u003c/a\u003e, \u003ca href=\"#_ENREF_56\"\u003e56\u003c/a\u003e). The resistance rate of ceftriaxone was significantly higher than that of ceftazidime, which may be related to the main cefotaxime (CTX) type of ESBL in this region. Carbapenems, Cephamycin and Piperacillin/tazobactam can be used as the first choice for empirical use, but doctors should adjust the drug according to the drug susceptibility results of clinical microbiology to reduce the occurrence of special and restricted antibiotic resistance.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;However, this study also has some limitations. Although the data of eight-year pancreatic cancer patients with Escherichia coli BSI were collected, the number of cases is still small. It is a single-center study, which can be combined for pancreatic cancer in North China. The diagnosis and treatment of pancreatic cancer patients with Escherichia coli BSI need further multi-center research to promote its application.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eEscherichia coli, the main pathogen causing BSI of cancer patients, is more common in pancreatic cancer patients. The independent risk factors include hospitalization days , chemotherapy and neutrophils larger than 5.5\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L. Therefore, patients with suspected BSI should be promptly drawn for blood culture. At the same time, clinical tests should be combined with laboratory tests such as neutrophils, albumin and prealbumin to make early diagnosis. Early use of medication, while timely adjustment based on clinical drug sensitivity results, will help reduce patient morbidity and mortality.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e"},{"header":"declarations ","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate:\u003c/strong\u003e \u0026nbsp;This study was approved by the Research Ethics Committee of TMUCIH. \u0026nbsp;All patients signed informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials : \u003c/strong\u003eThe data that support the findings of this study are available from the archives of the TMUCIH but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request to the corresponding author (Li Ren and Yueguo Li) and with permission of the TMUCIH.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication:\u003c/strong\u003e Not applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests: \u003c/strong\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e This work was supported by Grants 81871719 and 81802080 from Natural Science Foundation of China, Tianjin Medical University Cancer Institute and Hospital Grants Y1702, Y1711, Y1713.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions: \u003c/strong\u003eChangsen Bai designed the study and wrote the manuscript, Xiuse Zhang and Dong Yang collected the clinical data, Ding Li, Wenfang Zhang, Yunli Zhou, Qing Zhang and Shan Zheng did the bacterial identification and drug susceptibility experiments, Li Ren and Yueguo Li guided data analysis, manuscript writing and revision.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements: \u003c/strong\u003eThanks to the Natural Science Foundation of China, Tianjin Medical University Cancer Institute and Hospital Grants Y1702, Y1711, Y1713 for funding this research.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e"},{"header":"references ","content":"\u003col\u003e\n\u003cli\u003eMartin GS, Mannino DM, Eaton S, Moss M. 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The Journal of antimicrobial chemotherapy. 2018;73(3):634-42.\u003c/li\u003e\n\u003c/ol\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"tables","content":"\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;margin-top:7.8pt;margin-right:0in;margin-left:0in;text-indent:24.0pt;line-height:19.0pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1 \u0026nbsp; The ratio of pathogens in cancer patients complicated with BSI\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:420.0pt;margin-left:5.4pt;border-collapse:collapse;\" width=\"560\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:183.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:29.25pt;\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePathogen species\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 29.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of strains\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 29.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:29.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eComposition ratio（%）\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eEscherichia coli\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e776\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e645\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e28.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:183.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCoagulase-negative staphylococci\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e435\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e388\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e16.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eKlebsiella pneumoniae\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e349\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e310\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e13.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eStaphylococcus aureus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e137\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e110\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eEnterobacter cloacae\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e104\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eEnterococcus faecalis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePseudomonas aeruginosa\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e97\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eEnterococcus faecium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCandida albicans\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eOther pathogens\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e538\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e480\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e20.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2700\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2302\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e100.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;margin-top:7.8pt;margin-right:0in;margin-left:0in;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 2 Departmental distribution of cancer patients complicated with Escherichia coli BSI\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:420.0pt;margin-left:5.4pt;border-collapse:collapse;\" width=\"560\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:183.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDepartment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 30.75pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of strains\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 30.75pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eComposition ratio（%）\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePancreatic Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e8.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eHepatobiliary Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e8.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:183.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eIntegrated Traditional Chinese and Western Medicine Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e7.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eInterventional Therapy Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e7.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:183.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eIntensive care and treatment Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:65.8pt;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:28.5pt;\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eHematology oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e6.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDigestive Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eBiotherapy Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eRadiation Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eGynecologic Oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eOther oncology\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e290\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e258\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e40.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 183pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"43.49376114081996%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"13.368983957219251%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e776\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.686274509803921%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e645\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.6in;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"27.45098039215686%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e100.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left:5.4pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width: 446pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 38.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTable 3 Analysis of risk factors for Escherichia coli BSI in patients with pancreatic cancer\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:147.7pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"33.16498316498316%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eRisk factor\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:124.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"27.77777777777778%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eInfection group\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003en=31\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:123.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"27.60942760942761%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eControl group\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003en=93\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.447811447811448%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:56.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:27.75pt;\" width=\"18.796992481203006%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eNumber of cases\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:27.75pt;\" width=\"22.80701754385965%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eComposition ratio\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:27.75pt;\" width=\"18.546365914786968%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eNumber of cases\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:27.75pt;\" width=\"22.80701754385965%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eComposition ratio\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e%\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"17.04260651629073%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSex（Male)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e58.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e54.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAge\u0026nbsp;≥\u0026nbsp;60 years old\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e48.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e60.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eHospitalization days\u0026nbsp;≥7 days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e54.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e11.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of admissions≥2 times\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e96.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.5pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e84.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eSurgery\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e58.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e45.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eIntraoperative bleeding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e19.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e23.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChemotherapy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e67.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e49.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePrevious exposure to antibiotics≥ 2 species\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDistant organ metastasis of cancer\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e51.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e37.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrainage tube\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e38.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e34.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eMerger with other parts of infection\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e19.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e17.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eStayed in ICU\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e16.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e8.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eBlood transfusion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e16.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e19.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCombined with diabetes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e16.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e26.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePCT\u0026gt;2.2 μg/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;padding:0in 5.4pt 0in 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\u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:147.7pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"33.053691275167786%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePrealbumin\u0026lt;0.14 g/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"12.583892617449665%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e45.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"12.416107382550335%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"15.268456375838927%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e34.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:none;padding:0in 0in 0in 0in;\" width=\"11.409395973154362%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\n \u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width: 439.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 33.75pt;vertical-align: bottom;\" valign=\"bottom\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 4 Multivariate logistic regression analysis of Escherichia coli BSI in patients with pancreatic cancer\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eRisk factor\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eB\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eWaldχ\u003csup\u003e2\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eOR=Exp(B)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:17.25pt;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003e95%CI\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eHospitalization days\u0026nbsp;≥7 days\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e17.143\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e12.039\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e＜0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.200-45.286\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNumber of admissions≥2 times\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.435\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.813\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.201\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.367\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.186-95.063\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eChemotherapy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.901\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e8.698\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e6.691\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.368-20.561\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePrevious exposure to antibiotics≥ 2 species\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.486\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e3.602\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.058\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:30.0pt;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.777-18.613\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eWhite blood cells\u0026gt;7.4×10\u003csup\u003e9\u003c/sup\u003e /L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e-1.807\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.021\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.164\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.155\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.016-2.618\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNeutrophil\u0026gt;5.5×10\u003csup\u003e9\u003c/sup\u003e/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.698\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e19.105\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e14.853\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e＜0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;padding:0in 5.4pt 0in 5.4pt;height:.25in;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e4.430-49.804\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"34.923339011925044%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePCT\u0026gt;2.2 μg/L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"10.221465076660989%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.066\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"10.90289608177172%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.717\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:67.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"15.332197614991482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.903\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"12.43611584327087%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.397\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.75pt;\" width=\"16.1839863713799%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.246-34.248\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-top:15.6pt;margin-right:0in;margin-bottom:7.8pt;margin-left:0in;text-align:justify;line-height:19.0pt;font-size:20px;font-family:仿宋;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cstrong\u003eTable 5 Analysis of drug resistance of Escherichia coli BSI in pancreatic cancer and non-pancreatic\u003c/strong\u003e \u003cstrong\u003epatients\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-top:15.6pt;margin-right:0in;margin-bottom:7.8pt;margin-left:0in;text-align:justify;line-height:19.0pt;font-size:20px;font-family:仿宋;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\n \u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:328.35pt;border-collapse:collapse;\" width=\"438\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:39.15pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAntibiotic\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:39.15pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eNon-pancreatic cancer(n=750)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:39.15pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003epancreatic cancer(n=31)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.75in;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:39.15pt;\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cem\u003ep\u003c/em\u003e value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eESBL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e48.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e49.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.896\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAmpicillin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e80.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e82.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.782\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePiperacillin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e61.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e60.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.937\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAmpicillin/sulbactam\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e45.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e52.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.437\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003ePiperacillin/tazobactam\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd 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style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCeftazidime\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e20.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e1.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.789\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAztreonam\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e30.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e30.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.972\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eImipenem\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.803\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eMeropenem\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.803\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eAmikacin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e2.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.268\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eGentamicin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e48.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e39.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.283\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eTobramycin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e10.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.902\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eCiprofloxacin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e39.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.194\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:114.65pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"34.93150684931507%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003eLevofloxacin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e48.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e37.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size: 10px;\"\u003eSulfamethoxazole\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"25.799086757990867%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e60.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"22.831050228310502%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e56.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"16.438356164383563%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e0.689\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin-top:15.6pt;margin-right:0in;margin-bottom:7.8pt;margin-left:0in;text-align:justify;line-height:19.0pt;font-size:20px;font-family:仿宋;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0); font-size: 10px; font-family: Verdana, Geneva, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Pancreatic cancer, Escherichia coli, BSI, Clinical analysis, risk factor","lastPublishedDoi":"10.21203/rs.2.19350/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.19350/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground To study the common pathogens and cancer types of bloodstream infection (BSI) in cancer patients, find the risk factors and conduct clinical analysis.\u003c/p\u003e\u003cp\u003eMethods The clinical data of 2302 patients with BSI in Tianjin Medical University Cancer Institute and Hospital (TMUCIH) from January 2011 to December 2018 were retrospectively analyzed. 31 pancreatic cancer patients complicated with Escherichia coli BSI and 93 pancreatic cancer patients without BSI at the same period with similar sex and age were divided into infection group and non-infection group.\u003c/p\u003e\u003cp\u003eResults 645 strains (28%) of Escherichia coli were the main pathogens causing BSI in patients with cancer. 57 cases (8.8%) of cancer patients with Escherichia coli BSI were from pancreatic oncology department, among which 31 cases were diagnosed as pancreatic cancer by pathology. Multivariate logistic regression analysis showed that hospitalization days≥7, chemotherapy and neutrophil\u0026gt;5.5×10 9 /L were independent risk factors for pancreatic cancer patients complicated with BSI (P \u0026lt; 0.05). Quantitative analysis of serum-related indicators in infection patients and non-infection patients showed significant differences between albumin, prealbumin and neutrophils in infection and non-infection group. The ratio of Escherichia coli producing extended-spectrum ß-lactamase is 49.3 and 48.1 in pancreatic cancer and non-pancreatic patients. Escherichia coli resistant to carbapenems is rare, they were highly sensitive to Cephamycin and Piperacillin/tazobactam.\u003c/p\u003e\u003cp\u003eConclusions Escherichia coli, the main pathogen causing BSI of cancer patients, is more common in pancreatic cancer patients. The independent risk factors include hospitalization days≥7 days, chemotherapy and neutrophils larger than 5.5×10 9 /L. Quantitative indicators of neutrophil counts, albumin and prealbumin contribute to the early diagnosis of bloodstream infections. Early use of medication, while timely adjustment based on clinical drug sensitivity results will help reduce patient morbidity and mortality.\u003c/p\u003e","manuscriptTitle":"Clinical analysis of bloodstream infection of Escherichia coli in patients with pancreatic cancer","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-12-20 16:04:44","doi":"10.21203/rs.2.19350/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"8a242a9d-8f79-4c11-aeb9-d128c1df5435","owner":[],"postedDate":"December 20th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":44399,"name":"General Microbiology"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-12-20 16:04:44","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-9963","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-9963","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}