The Relationship between Decorin and VEGF in Endometriosis

Gültekin Adanaş Aydın, Gultekin Adanas Aydin, Habibe Ayvaci, Habibe Ayvacı, Nermin Koç, Nermin Koc, Nazan Tarhan, Oya Demirci
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP · 2021 · vol. 31(11) , pp. 1285–1290 · doi:10.29271/jcpsp.2021.11.1285 · PMID:34689484 · W3211002271
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that endometriosis patients showed lower decorin and higher VEGF staining in endometrial and ovarian tissues compared to controls, indicating a negative correlation between the two factors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This retrospective single-center descriptive study compared immunohistochemical staining of decorin and vascular endothelial growth factor (VEGF) in archived ovarian and endometrial tissues from 20 patients with an endometrioma and 10 controls undergoing hysterectomy/oophorectomy for benign gynecologic pathologies, with samples collected in the proliferative menstrual phase. The study found lower decorin staining intensity and higher VEGF staining intensity in both endometrial and ovarian tissues in the endometriosis group versus controls, along with a significant negative correlation between VEGF and decorin staining in endometrium and ovary. Limitations include the small sample size and reliance on semi-quantitative IHC scoring by a single experienced pathologist. This paper is centrally about endometriosis — it examines the relationship between decorin and VEGF expression in endometrial and ovarian tissues from patients with endometrioma versus controls.

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Abstract

OBJECTIVE: To evaluate immunohistochemical (IHC) staining of decorin and vascular endothelial growth factor (VEGF) of ovarian and endometrial tissues in patients with and without endometriosis. Study Design: Descriptive study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Gynecology, ZeynepKamil Training and Research Hospital, Istanbul, Turkey, between Istanbul, TurkeyJanuary 2018 and June 2019. METHODOLOGY: Thirty patients, who underwent total abdominal hysterectomy (TAH) + bilateral salpingo-oophorectomy (BSO)/unilateral salpingo-oophorectomy (USO) and were in the proliferative phase of menstrual cycle,were included. The study population consisted of 20 patients (patient group) with an endometriomaand the control group consisted of 10 patients who were operated for benign gynecological pathologies.The ovarian and endometrial tissue specimens were collected from the archives. IHC staining was performed using decorin and VEGF. RESULTS: Decorin analysis showed a significantly higher intensity of staining in both endometrial and ovarian tissues in control group than patient group. Patients with endometriosis had a lower intensity of staining of decorin and a higher intensity of staining of VEGF compared to control group. There was a negative, statistically significant concordance between VEGF and decorin staining of endometrial tissues of both groups (concordance rate -0.560, p=0.001). Therewas a negative, statistically significant concordance between VEGF and decorin staining of ovarian tissues of both groups (concordance rate -0.564, p<0.001). CONCLUSION: Angiogenesis plays a critical role in endometriosisand interaction between decorin and VEGF,which suggests that decorin may be a promising molecule for the treatment of endometriosis. Key Words: Decorin, Endometriosis, Immunohistochemical staining, Vascular endothelial Growth factor.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Vascular Endothelial Growth Factor A Decorin Endometrium Female Humans Vascular Endothelial Growth Factors

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