Research on wireless precise nerve electrical stimulation method based on liquid metal

Research on wireless precise nerve electrical stimulation method based on liquid metal | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Research on wireless precise nerve electrical stimulation method based on liquid metal Yuheng Wang, Junjie Lin, Kai Zhu, Yuhui Nie, Mengyuan Wang, Xiaoxu Ma, and 13 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4491891/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 07 Apr, 2025 Read the published version in Journal of NeuroEngineering and Rehabilitation → Version 1 posted 9 You are reading this latest preprint version Abstract Background Neural electrical stimulation is a crucial technique for treating central nervous system and peripheral nervous system disorders. However, the use of invasive electrodes presents risks such as high implantation risk, mechanical stress, electrical connection requirements, power supply difficulties. On the other hand, non-invasive magnetic stimulation has limitations such as centimeter-level focal areas and shallow stimulation depth. Methods To overcome these challenges, we propose a minimally invasive approach that involves the injection of a highly conductive, flexible liquid metal (LM) combined with an 8-shaped magnetic stimulation coil (8-coil). This combination aims to enhance the precision and effectiveness of wireless electrical stimulation. An electric field measurement platform was established, and the efficacy of this method was validated through stimulation of the sciatic nerve in mice. Results Theoretical analysis and finite element simulations demonstrated that the combination of LM and 8-coil produces a millimeter-scale enhanced vector electric field within tissues. The actual measured electric field distribution closely aligned with theoretical and simulated outcomes. In experiments involving mouse sciatic nerves, 1 μL of LM in a 0.45 T magnetic field significantly increased electromyographic signals and leg movement amplitude by 500%, with no adverse reactions observed. Conclusions This method utilizes focused electric fields to improve the precision and effectiveness of neuro-electromagnetic stimulation. It holds promise as a novel approach for precise electrical stimulation. Full Text Additional Declarations No competing interests reported. Supplementary Files SupportingInformation.docx video.mp4 Cite Share Download PDF Status: Published Journal Publication published 07 Apr, 2025 Read the published version in Journal of NeuroEngineering and Rehabilitation → Version 1 posted Editorial decision: Revision requested 15 Jul, 2024 Reviews received at journal 15 Jul, 2024 Reviews received at journal 24 Jun, 2024 Reviewers agreed at journal 14 Jun, 2024 Reviewers agreed at journal 13 Jun, 2024 Reviewers invited by journal 10 Jun, 2024 Editor assigned by journal 07 Jun, 2024 Submission checks completed at journal 07 Jun, 2024 First submitted to journal 28 May, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4491891","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":316074751,"identity":"1248b4f6-2fdc-4812-8207-9f3b30f3f996","order_by":0,"name":"Yuheng Wang","email":"","orcid":"","institution":"Institute of Biomedical Engineering, Chinese Academy of Medical Science \u0026 Peking Union Medical College","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yuheng","middleName":"","lastName":"Wang","suffix":""},{"id":316074752,"identity":"d12ad90c-2d7b-4ca7-af7e-d8c6682f66a9","order_by":1,"name":"Junjie 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