White Matter Tract Disruptions Predict Less Affected Hand Impairment Following Stroke: A Longitudinal Diffusion MRI Study

Abstract Although less-affected hand (LAH) deficits following unilateral stroke are well documented, many aspects of LAH impairment mechanisms remain unresolved. To provide a better understanding of these mechanisms, we used diffusion MRI to examine the disruptions of white matter structural connections. Based on the redundancy theory, we hypothesized that a summation of motor-related tract disruptions would characterize LAH impairment. We assessed LAH impairment and fractional anisotropy (FA) in 28 patients at one-month post-stroke (baseline), and 6 and 24 months later. LAH impairment was assessed with the Purdue Pegboard Test (PPT), handgrip strength, and movement time. FA was estimated in the CST, Anterior- Corona Radiata (ACR), and Limb of Internal Capsule (ALIC), Superior Longitudinal Fasciculus (SLF), and corpus callosum (CC). We used Linear Mixed Models to determine the tracts associated with LAH impairment over time. Baseline PPT, grip, and movement time were impaired in 43%, 61%, and 25%, respectively. PPT was modeled by baseline ipsilesional-CST (t=3.75; p<0.001), ipsilesional-SLF (t=3.19; p=0.002), contralesional-ALIC (t=-4.89; p<0.001), and lesion volume (t=-3.18; p=0.004); handgrip by baseline ipsilesional-CST (t=3.39; p=0.001), contralesional-ALIC (t=-3.91; p<0.001) and sex (t=-1.43; p=0.007); movement time by baseline ipsilesional-SLF (t=-3.64; p=0.001), CC (t=4.00; p=<0.001), and lesion volume (t=3.03; p=0.006). In conclusion, white matter tract disruptions determine the LAH impairment profile, with ipsilesional-CST related to motor and ipsilesional-SLF to visuomotor processing. LAH impairment was associated with the summation of several tract disruptions, supporting the concept of cerebral redundancy. These results provide a theoretical basis for integrating LAH in rehabilitation programs and for treatment interventions such as neuromodulation.