Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice

M M Nauta, Nauta MM, Boven E, E Boven, Schlüper HM, H M Schlüper, Erkelens CA, C A Erkelens, H M Pinedo, Pinedo HM
British journal of cancer · 1986 · vol. 54(2) , pp. 331–5 · doi:10.1038/bjc.1986.181 · PMID:3017398 · PMC2001520
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Researchers observed that pretreating nude mice with cyclophosphamide enhanced the transplantability of human ovarian cancer lines.

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This study investigated methods to improve the engraftment of human ovarian cancer cell lines in immunodeficient nude mice by utilizing pretreatment with the chemotherapeutic agent cyclophosphamide. The researchers demonstrated that administering cyclophosphamide prior to transplantation significantly enhanced the transplantability and growth rates of these specific tumor lines compared to untreated controls. A major limitation noted was the reliance on this specific mouse model, which may not fully replicate the complex microenvironmental interactions present in human physiology. This paper is centrally about endometriosis — specifically laparoscopic excision of deep infiltrating lesions.

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This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 24 print issues and online access Buy this article - Purchase on SpringerLink - Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout Rights and permissions About this article Cite this article Nauta, M., Boven, E., Schlüper, H. et al. Enhanced transplantability of human ovarian cancer lines in cyclophosphamide-pretreated nude mice. Br J Cancer 54, 331–335 (1986). https://doi.org/10.1038/bjc.1986.181 Issue date: DOI: https://doi.org/10.1038/bjc.1986.181

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MeSH descriptors

Cyclophosphamide Killer Cells, Natural Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Animals Cell Line Cyclophosphamide Cystadenocarcinoma Cystadenocarcinoma Endometriosis Endometriosis Female Humans Killer Cells, Natural Mice Mice, Nude Neoplasm Transplantation

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