Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial results

Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial results | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial results Shaopeng Li, Shuhang Liang, Mengqiu Liu, Xudan Chen, Dawei Yin, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8275712/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 Apr, 2026 Read the published version in Abdominal Radiology → Version 1 posted 11 You are reading this latest preprint version Abstract Background We aimed to evaluate the utility of 5-T gadoxetic acid (Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid, Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) by intraindividual comparison with 3-T, focusing on image quality and diagnosis of hepatocellular carcinoma (HCC). Methods We prospectively enrolled 28 patients with suspected HCC who underwent dynamic Gd-EOB-enhanced MRI using both 5-T and 3-T scanners. Artificial intelligence-assisted compressed sensing (ACS) and parallel imaging (PI) were both used for hepatobiliary phase (HBP) imaging at 5-T. Two radiologists performed the qualitative and quantitative assessments of image quality, and the evaluation of imaging features. Wilcoxon signed-rank, paired χ 2 , and Cochran Q test as well as intraclass correlation coefficients and Cohen κ were used. Results All subjective image quality scores were rated as good to excellent. The subjective scores of contrast-enhanced phases at 5 T were higher than those at 3 T ( p ≤ 0.016) except for image artifacts. Quantitative measures were also greater at 5 T ( p ≤ 0.019). Subjective and quantitative assessment of HBP imaging were higher with ACS ( p ≤ 0.046). The detection rate of enhancing HCC capsule was higher at 5 T ( p = 0.031), as well as the peritumoral hypointensity on the HBP image at 5 T using ACS ( p = 0.039). Conclusions Liver dynamic Gd-EOB-DTPA-enhanced 5-T MRI demonstrated superior image quality for contrast-enhanced phases and greater sensitivity in detecting the HCC enhancing capsule compared with 3-T MRI. The integration of 5-T MRI and ACS technology holds the potential to further improve image quality and the assessment of imaging features. Relevance statement Gd-EOB-DTPA-enhanced 5-T MRI provides promising potential for accurate HCC evaluation. Artificial intelligence Carcinoma (hepatocellular) Gadolinium ethoxybenzyl DTPA Liver neoplasms Magnetic resonance imaging Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Purpose Hepatocellular carcinoma (HCC) is the most prevalent primary malignant tumor of the liver, characterized by a high incidence and mortality rate. Early diagnosis of HCC is crucial for timely treatment and improved prognosis. Research indicates that, compared to ultrasound and computed tomography, multiparametric magnetic resonance imaging (MRI) is more effective in detecting liver focal lesions with non-typical ultrasound/computed tomography features, thereby avoiding unnecessary biopsies due to its superior spatial resolution and optimal soft tissue contrast [ 1 ]. Contrast-enhanced MRI is widely used in detecting and characterizing liver lesions. The liver cell-specific contrast agent gadoxetic acid (Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid, Gd-EOB-DTPA) possesses a dynamic enhancement effect similar to that of extracellular contrast agents (ECAs) in arterial phase (AP) and portal venous phase (PVP), and is specifically absorbed by liver cells at hepatobiliary phase (HBP), making it a bifunctional contrast agent [ 2 ]. It has been proved that Gd-EOB-DTPA-enhanced MRI significantly improved the detection rate and diagnostic accuracy of small (≤ 20 mm) and subcentimeter (<10 mm) focal lesions [ 3 , 4 ]. The development of ultrahigh-field MRI has improved the limited spatial resolution and signal-to-noise ratio (SNR) of MRI. There is a growing interest in employing ultrahigh magnetic fields in whole-body MRI systems to explore their potential clinical applications. Recently, a 5-T whole-body MRI scanner has been introduced, which may offer advantages for abdominal imaging. Previous studies have shown that 5-T MRI provides superior image quality than 3-T, including higher SNR, better tumor identification, and clearer bile duct display in functional imaging and conventional plain scan [5 − 8]. On the other hand, there is a trade-off between the acquisition time and spatial resolution of MRI [ 9 ]. In order to obtain high spatial resolution images, the scanning time will increase and the SNR may decrease [ 10 ]. Thus, it is both crucial and challenging to conduct high-resolution liver MRI examinations with appropriate breath-holding times without compromising image quality [ 11 ]. In comparison to current acceleration techniques such as parallel imaging (PI), the advent of artificial intelligence-assisted compressive sensing (ACS) has established a balance between scanning time and image quality [ 12 , 13 ]. Previous studies have demonstrated that ACS significantly reduced scanning time without sacrificing image quality when compared to PI, thereby enhancing efficiency and minimizing motion artifacts [12 − 14]. We aimed to evaluate and compare image quality of plain and Gd-EOB-DTPA-enhanced MRI of HCC as well as the display of imaging features − including major and ancillary features of Liver Imaging Reporting and Data System (LI-RADS) version 2018 [ 15 ] − obtained at 5 and 3 T. Methods Study design and participants This study is a single center, head to head controlled prospective study in accordance with the Declaration of Helsinki and has been approved by the Ethics Review Committee of the First Affiliated Hospital of the University of Science and Technology of China (2022KY-267). All patients provided written informed consent before the examination. Between September 2023 to December 2024, patients suspected of having HCC were enrolled. Inclusion criteria: (1) ≥ 18 years old; (2) Underwent 5-T gadoxetic acid-enhanced MRI. Exclusion criteria: (1) The patient didn't meet the LI-RADS v2018 criteria for high-risk populations;(2) Participants who withdrew from the trial and did not undergo the scheduled 3-T gadoxetic acid-enhanced MRI; (3) Not indicated for surgical resection [ 16 ];(4) Final pathological results negative for HCC/ICC or without pathological. Finally, 28 patients were included in this study (Fig. 1). Image acquisition After admission, all patients underwent MRI using a 5-T scanner (uMR Jupiter, United Imaging Healthcare, Shanghai, China) and a 3-T scanner (uMR 870, United Imaging Healthcare, Shanghai, China), both of them with a 24-channel body coil. The interval time between the 5-T and 3-T acquisitions was from two days to one week. All participants were informed of the potential risks associated with high-field MRI, including mild nausea, dizziness, headache, etc., as well as the purpose of the examination and the risk of contrast agent allergies. Respiratory coordination training was conducted before the scan to reduce the potential impact of respiratory artifacts. In order to purely compare effects of magnetic field strength on the image quality, same sequences and parameters were used at 3 and 5 T, and the spatial resolution was consistent in paired sequences. The imaging sequences included unenhanced axial three-dimensional (3D fast spoiled gradient-echo T1-weighted imaging (“quick-3D” in United Imaging Healthcare systems), axial fast spin echo T2-weighted imaging, diffusion-weighted imaging, and dynamic contrast enhanced scanning (Supplementary Tables S1 and S2). For pre- and post-contrast scanning including HBP imaging, quick-3D sequence was applied. The liver cell-specific contrast agent, gadoxetic acid (Gd-EOB-DTPA, Primovist; Bayer Healthcare, Berlin, Germany), was injected into the elbow vein at a rate of 1 − 2 mL/s using a high-pressure injector with a dose of 0.1 mL/kg, and then rinsed with 20 mL of saline. Early and late AP phase, PVP, transitional phase (TP), and HBP images were collected at 15 s, 60 s, 120 s, and 20 min after the injection of the contrast agent, respectively. During dynamic imaging, all quick-3D sequences were accelerated by PI method at 3 and 5 T. For HBP imaging, PI and ACS were both applied at 5-T. Image analysis All sets of pre- and post-contrast images were transmitted to the postprocessing workstation (uWS-MR, United Imaging Healthcare, Shanghai, China) for image analysis and related parameter measurement. Two abdominal radiologists (with five and ten years of work experience) evaluated all images without knowing the patients information, pathological diagnosis, and field strength. Subjective evaluation The two radiologists independently and subjectively evaluated pre- and post-contrast images at 5 and 3 T with respect to image artifacts, lesion edge clarity, liver edge clarity, and overall image quality. The scoring criteria for image artifacts and overall image quality adopt the 5-point Likert scale: 1 point, severe artifacts with image distortion, not diagnostic; 2 points, obvious artifacts, the image is blurry and affects diagnosis; 3 points, moderate artifacts, possibly diagnostic; 4 points, mild artifacts, good image quality; 5 points, no artifacts, excellent image quality. A 5-point scale was used to assess the edge clarity, 1 = no visible boundary; 2 = ill-defined boundary; 3 = obscure boundary; 4 = well defined boundary; 5 = excellent boundary. The average subjective scores of the two radiologists were taken as the final scores. Objective evaluation The two radiologists determined regions of interest (ROIs) independently. Four ROIs of fixed size (approximately 100 mm 2 ) were placed at the second porta hepatis level of each sequence to measure the signal intensity (SI) of the liver parenchyma in the left inner, left outer, right anterior, and right posterior lobes, avoiding blood vessels, bile ducts, and lesions. Then these four ROIs were copied to other sequences. To measure the SI of the lesion, the slice displaying the maximum cross-section area of the lesion, and its adjacent upper and lower slices were selected for ROI drawing. The lesion ROIs were determined on the three slices to cover the entire lesion as much as possible and avoid necrosis and bleeding. The SNR, contrast-to-noise ratio (CNR) and contrast ratio (CR) were calculated as follows: SNR = SI liver / SD background CNR = |SI liver - SI lesion | / SD background CR = |SI liver - SI lesion | / SI liver + SI lesion where SI liver is the averaged SI within four liver parenchyma ROIs, SI lesion is the averaged SI within three lesion ROIs, and SD background is the mean standard deviation (SD) of the four corners of the background on the same slice where the ROIs for normal liver tissues were placed (Supplementary Fig S1 ). The average objective scores of two radiologists were taken as the final scores. Display of HCC features The two abdominal radiologists documented anatomical location and size of the target nodules together. They evaluated all LI-RADS major features (non-rim AP hyperenhancement, nonperipheral washout, enhancing capsule, and threshold growth), features of LI-M (rim AP hyperenhancement, peripheral washout, delayed central enhancement, targetoid restriction, and targetoid TP/HBP appearance), as well as specific ancillary features (nonenhancing capsule, nodule in nodule, mosaic structure, blood products in mass, and fat in mass), based on LI-RADS v2018. In addition, due to the important value of corona enhancement and peritumoral hypointensity on the HBP image [ 17 ], as well as arterial vessels in HCC [ 18 ], the two readers also evaluated these three features. When there was a discrepancy in image interpretation between two radiologists, the final decision was determined by a third radiologist, with 24 years of experience in liver imaging. Statistical analysis Sample size estimation for the paired design was conducted using PASS 2025, version 25.0.2 [ 19 ]. The comparison was made using a one-sided, paired-difference t -test, with a type I error (α) rate of 0.05. The underlying standard deviation of the paired difference distribution was assumed to be 0.7. To detect a paired mean difference of 0.4 with 90% statistical power (1-β), the number of needed pairs was 28. Other statistical analyses were conducted using SPSS 26.0 software (IBM Corp., Armonk, New York, USA). Shapiro-Wilk test was used to perform normality test on the data. Continuous data are reported as mean ± SD and were compared using the paired Student’s t -test for a normal distribution and Wilcoxon signed rank test for a non-normal distribution. Count data are expressed as frequencies and percentages. Paired χ 2 test was used for comparisons between 3-T and 5-T scans and Cochran Q test was applied to compare three groups of data. Intraclass correlation coefficient (ICC) and Cohen κ were used to assess the consistency between the two readers. Agreement levels were interpreted as follows: not consistent (0.01 − 0.20); poor (0.21 − 0.40); moderate (0.41 − 0.60); good (0.61 − 0.80); and excellent (0.81 − 0.99). Two-tailed p < 0.05 indicates statistically significant difference. Results Patient characteristics We included 28 high-risk HCC patients, comprising 24 males and 4 females, aged between 42 and 76 years, aged 60.07 ± 9.07 years. All patients underwent surgery or biopsy to obtain pathological results and the results confirmed HCC. Among these patients, there were 27 cases of single lesion, and one case of two lesions. Furthermore, all enrolled patients successfully completed 3-T and 5-T MRI without complications and there were no patients whose images could not be evaluated due to severe respiratory artifacts. The patient clinical characteristics are presented in Table 1. Subjective evaluation and inter-observer consistency The κ values of subjective scores from the two abdominal radiologists for all image sets obtained at 3 and 5 T ranged from 0.644 to 0.867, indicating good to excellent consistencies (Supplementary Tables S3 and S4). There was no statistically significant difference in all subjective scores of pre-contrast sequences and artifact scores of all sequences between 3 and 5 T. Compared with 3-T MRI, 5-T MRI had significantly higher scores in lesion edge clarity, liver edge clarity, and overall image quality for all post-contrast enhanced images (Table 2). Moreover, all subjective scores except image artifacts of ACS images were significantly higher than that of PI images for HBP imaging at 5 T (Table 3). Objective evaluation and inter-observer consistency The ICCs of SNR and CNR from the two abdominal radiologists for all image sets obtained at 3 and 5 T ranged from 0.730 to 0.930, indicating excellent consistencies (Supplementary Table S5). Summaries of SNR, CNR and CR of pre- and post-contrast enhanced quick-3D images at 3 and 5 T are shown in Fig. 2. There was no statistically significant difference between pre-contrast enhanced quick-3D images between different field strengths, while SNR, CNR and CR of post-contrast enhanced images of 5-T MRI were significantly higher. The SNR, CNR and CR of ACS-accelerated HBP sequence were also significantly superior to those of PI-accelerated sequence at 5 T (Table 4). Detection of imaging features in HCC and non-HCC malignancy Using LI-RADS v2018, 27 lesions were categorized as LR-5, and 2 lesions were categorized as LR-M. No lesion was categorized as LR-TIV by the two radiologists (Supplementary Table S6). Regarding the enhancing capsule, 16 cases were detected on PVP/TP images at 3 T, 22 cases were detected on PVP/TP images at 5 T (Fig. 3). The detection rate of enhancing capsule was significantly higher at 5 than at 3 T ( p = 0.031) (Table 5). On HBP images, 4 and 5 cases of peritumoral hypointensity were detected by PI-accelerated quick-3D at 3 and 5 T, respectively, and 8 cases were detected based on ACS-accelerated HBP imaging at 5 T, with a significant difference ( p = 0.039) (Fig. 4). The pairwise comparison showed that the detection rate of ACS sequence at 5 T was higher than that of PI sequence at 3 T ( p = 0.043) (Supplementary Table S7). For corona enhancement on AP images, 3 cases were observed at 3 T and 5 cases at 5 T (Fig. 5). Arterial vessels within the lesion were detected in 11 cases at 3, and 13 at 5 T (Fig. 6). The detection rate of other major/ancillary features and features of LI-M were consistent between the two field strengths (Supplementary Table S8). All enrolled patients were found to have liver lesions on their first examination, and the major feature of threshold growth was not applicable. Discussion In this study, we compared 3-T and 5-T MRI in the diagnosis of HCC. The results showed that Gd-EOB-DTPA-enhanced MRI was superior at 5 T than at 3 T in terms of subjective evaluations of lesion edge clarity, liver edge clarity, and overall image quality, as well as considering the objective evaluations of SNR, CNR, and CR. In terms of displaying imaging features of HCC, 5-T MRI combined with ACS technology was superior to 3-T MRI. The combination of 5-T MRI and ACS technology can improve the quality of liver images and facilitate the display of HCC imaging features. Influence of magnetic field strength on image quality The image quality of MRI depends on factors such as SNR, CNR, spatial resolution, and artifacts. As the SI is linearly proportional to B 0 field strength, higher field could help improve SNR, CNR, and allow the application of high resolution imaging [ 20 ]. However, at high magnetic field strengths (> 3 T), the risk of distortion increases due to the inhomogeneity of B 0 and B 1 fields, and the specific absorption rate increases, especially in abdominal imaging [ 21 , 22 ]. Therefore, most ultrahigh-field studies were limited to neuroimaging and musculoskeletal imaging [ 23 , 24 ]. Recently, the 5-T ultrahigh-field scanner has been put into clinical application, and studies have shown that both functional imaging such as diffusion-weighted and conventional plain scanning have obtained high-quality images of abdominal organs including liver, pancreas, kidneys [5 − 7,25]. These applications indicate that 5-T MRI has advantages on better SNR, CNR, CR and high spatial resolution imaging, giving the potential in displaying fine structures such as small tumors and complex anatomical structures, which can effectively reduce the risk of missed diagnosis [ 26 ]. This study demonstrated that the image quality of contrast-enhanced images at 5 T were significantly superior to that at 3 T. Previous in vitro experiments have shown that native T1 relaxation time increased at higher field strengths, which may be the reason of improved contrast enhancement [ 27 ]. As the field strength increases, due to the combined effect of protein binding, the increase in T1 value of tissues leads to a corresponding increase in relative contrast, ultimately resulting in a significant change in T1 relaxation value under high magnetic field strength [ 28 ]. Jiong et al. [ 29 ] set similar repetition time, echo time, and flip angle in sequences at 3 and 5 T and the results showed that the contrast between tumor and brain tissue in the half-dose contrast-enhanced images at 5 T was significantly higher than that in the full-dose contrast at 3 T. There was no statistically significant difference between the unenhanced images obtained at 3 and 5- T in this study, which may be due to the fact that the sequence parameters at 5 T were adjusted to be consistent with 3 T for comparison instead of being optimized to meet hardware limits. To mitigate industry-related bias, we applied several strategies. First, the 3-T and 5-T scanners were from the same manufacturer. Systematic errors have been minimized by the consistency in hardware and software. Second, same imaging sequences were used and parameters were set as identical as possible across different scanners. Besides, all image sets were reviewed on the same workstation and radiologists were blinded to any image information including the field strength. These strategies reinforced that image quality differences were attribute to field strength rather than industry-related confounders. Advantages of ACS technology in contrast-enhanced sequences MRI has unique advantages in displaying the structure of lesions and abdominal organs. However, the drawbacks includes long scanning time and is prone to artifacts, which is especially inevitable in abdominal imaging [ 30 ]. Common abdominal MRI artifacts include partial volume effects and motion/pulsation artifacts. In clinical settings, thin-slice and high spatial resolution imaging reduces local volume effects, and improves visibility and detection rates of small lesions, while increases scanning time and affects SNR. At present, commonly used acceleration techniques including CS, PI, and half-Fourier acquisition. However, when using high acceleration factors, these techniques may generate various artifacts and amplified noise during the image reconstruction process, thereby reducing image quality [ 31 – 35 ]. ACS follows the principles of half-Fourier, PI, and CS, and combines artificial intelligence modules in the reconstruction process [ 36 ], which reduces noise and artifacts, and corrects shortcomings of conventional acceleration techniques, providing reliable images for clinical diagnosis in a shorter time [ 37 , 38 ]. Li et al. [ 12 ] compared the ACS-accelerated single breath-hold T2-weighted images with traditional respiratory-triggered T2-weighted images, and showed that ACS provided better abdominal image quality, lesion detection rate, and greatly reduced the scanning time. In another nasopharyngeal study [ 39 ], ACS not only shortened the scanning time, but also improved image quality. Our study applied ACS to thin-slice iso-resolution HBP imaging and obtained similar results to previous studies that subjective scores, SNR, CNR and CR were significantly higher than PI-accelerated sequence scanned with thicker slices, indicating that ACS-accelerated HBP imaging could clearly display the liver and lesions without increasing scan time. Detection of imaging features of HCC According to LI-RADS v2018 [ 15 ], enhancing capsule is a smooth peripheral edge enhancement during PVP in ECA-enhanced MRI or PVP/TP in Gd-EOB-DTPA-enhanced MRI. Compared with ECA-enhanced MRI, the sensitivity for LR-5 is reduced when using Gd-EOB-DTPA-enhanced MRI [ 40 ], which is a major challenge as LI-RADS was originally designed for ECA-enhanced MRI [ 41 ], and the degree of tumor parenchymal enhancement in Gd-EOB-DTPA-enhanced MRI is lower [ 42 ]. As the SI of the background liver tissue gradually increases in Gd-EOB-DTPA-enhanced MRI, the enhanced capsule is usually masked by the background liver tissue, thereby reducing the detection rate of this feature [ 43 ]. In order to improve the diagnostic sensitivity of enhanced capsule, Chung et al. [ 44 ] proposed using subtraction method to increase the detection rate of enhanced capsule. Kim et al. [ 45 ] modified the scanning sequence by replacing the traditional single PVP with the double PVP, which also improved the detection rate of enhanced capsule. The results of our study showed that compared to 3-T MRI, 5-T MRI can improve the detection enhanced capsule, improving the accuracy of HCC diagnosis. As an ancillary feature of malignant tumor, corona enhancement has been shown to be an important predictor for HCC microvascular invasion [ 46 ]. Although arterial vessels within tumors and peritumoral hypointensity on the HBP image are not major or ancillary features, they are crucial for HCC diagnosis, prognosis, and determination of treatment strategies [ 47 , 48 ]. Our study showed that the above features could be more clearly displayed at 5 T compared to 3 T, or ACS compared to PI sequences. The difference in detection rate of peritumoral hypointensity on the HBP image was significantly higher at 5-T ACS sequence, and the detection rates of corona enhancement and arterial vessels within tumors had also been improved with 5-T MRI, although the difference was not statistically significant. Since we had only two intrahepatic cholangiocarcinomas, the detection rate of LR-M features were consistent between 5-T and 3-T MRI. LR-M features including rim APHE, peripheral washout, delayed central enhancement and targetoid TP/HBP appearance can all be seen in these two cases. This study has several limitations. First, 5-T MRI is still in its early stages, and the development of technology makes it challenging to ensure the use of completely consistent software platforms and phased array circles to obtain 3-T and 5-T scans. In fact, phased array coils produced for systems with different magnetic field strengths will have different performance characteristics, which makes it challenging to compare image quality and SNR that rely solely on magnetic field strength. Second, our study population is relatively small. This may also be the reason why there is no statistical difference in partial imaging features between 3 and 5 T. Another limitation is that all subjects underwent 3-T scan at after the 5-T scan. Although there was an at least 48-hour interval between the two injections of contrast agent, residual contrast agent in tumors and organs may have influenced the image quality, SNR and CNR. However, our research results showed no significant difference in image quality between unenhanced 3-T and 5-T, suggesting that the impact of residual contrast agents on image quality may not interfere with subsequent image quality analysis. Finally, we did not include non-HCC lesions to evaluate diagnostic performance. However, the primary objective of this study was to compare HCC detection and image quality. In summary, 5-T MRI showed significant advantages over 3-T MRI with respect image quality and diagnosis of HCC. Furthermore, Gd-EOB-DTPA-enhanced MRI combined with ACS technology at 5 T obtained better image quality with same spatial resolution to display HCC imaging features, such as peritumoral hypointensity on HBP images, without increasing the scanning time. Abbreviations 3D Three-dimensional ACS Artificial intelligence-assisted compressive sensing AP Arterial phase CNR Contrast-to-noise ratio CR Contrast ratio ECA Extracellular contrast agent Gd-EOB-DTPA Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid (gadoxetic acid) HBP Hepatobiliary phase HCC Hepatocellular carcinoma LI-RADS Liver Imaging Reporting and Data System MRI Magnetic resonance imaging PI Parallel imaging PVP Portal venous phase quick-3D 3D fast spoiled gradient-echo T1-weighted sequence ROI Region of interest SD Standard deviation SI Signal intensity SNR Signal-to-noise ratio TP Transitional phase Declarations Ethics approval and consent to participate The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Review Committee of the First Affiliated Hospital of the University of Science and Technology of China (approval number 2022KY-267, date of approval 27/10/2022). Consent for publication Not applicable. Availability of data and material All results of this study are presented in the manuscript in the form of tables, including scanning parameters. The datasets generated or analyzed during the study are available from the corresponding author upon reasonable request. Competing interests Zhichao Feng, Runyu Tang and Xiaopeng Song were employees of United Imaging Healthcare throughout their involvement in the study. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Funding This study has received funding by National Key RandD Program of China (2019YFA0709300). Authors' contributions Shaopeng LI: onceptualization, data curation, methodology, project administration, validation, writing – original draft and review, and editing. Shuhang Liang, PhD: data curation, formal analysis, project administratio Mengqiu Liu: data curation, methodology, validation. Xudan Chen: data curation, resources, validation Dawei YIN: data curation, project administration, validation. Zhichao Feng: investigation, methodology, software, writing—review, and editing. Runyu Tang and Xiaopeng Song: formal analysis, methodology, software, writing–review, and editing. Peng Wan: project administration, supervision, validation. Lianxin Liu: conceptualization, formal analysis, funding acquisition, supervision, visualization, writing–review, and editing. Ying Liu: conceptualization, project administration, supervision, visualization, writing-original draft, review, and editing. Acknowledgements The authors would like to thank all participants for their contribution to this study. We did not use Large Language Models for the conceptualization or creation of this manuscript. References Chartampilas E, Rafailidis V, Georgopoulou V et al (2022) Current imaging diagnosis of hepatocellular carcinoma. 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Korean J Radiol 25:887–901. https://doi.org/10.3348/kjr.2024.0307 Tables Table 1 Clinical characteristics of the patients Characteristics Values Number 28 Age (years) 60.07 ± 9.07 Sex Male 24 (85.71%) Female 4 (14.29%) Tumor size (cm) 5.41 ± 2.60 Etiology of liver disease Hepatitis B 25 (89.29%) Hepatitis C 2 (7.14%) Alcoholic liver disease 1 (3.57%) Cirrhosis Presence 15 (53.57%) Absence 13 (46.43%) Tumor markers Alphafetoprotein (ng/mL) >200 8 (28.57%) 7 − 200 7 (25.00%) < 7 13 (46.43%) CA19-9 (U/mL) 100 2 (7.14%) Number of lesions 1 27 (96.43%) 2 1 (3.57%) Per-patient final diagnosis Intrahepatic cholangiocarcinoma 2 (6.90%) Hepatocellular carcinoma 27 (93.10%) Edmondson-Steiner grade Ⅰ 3 (11.11%) Ⅱ 10 (37.04%) Ⅲ 13 (48.15%) Ⅳ 1 (3.70%) CA19-9 Carbohydrateantigen19-9. Table 2 Image quality scores for 3-T and 5-T images T Precontrast Early-AP Late-AP PVP TP HBP Image artifacts 3 3.75 ± 0.51 3.82 ± 0.51 3.91 ± 0.58 3.63 ± 0.49 3.73 ± 0.65 3.75 ± 0.55 5 3.89 ± 0.49 3.95 ± 0.55 4.07 ± 0.50 3.79 ± 0.53 3.95 ± 0.7 3.91 ± 0.61 p value 0.088 0.226 0.095 0.085 0.083 0.140 Clarity of lesion margins 3 3.70 ± 0.53 3.73 ± 0.62 3.71 ± 0.71 3.61 ± 0.64 3.66 ± 0.64 3.68 ± 0.61 5 3.89 ± 0.53 4.14 ± 0.44 4.27 ± 0.49 4.18 ± 0.43 4.09 ± 0.44 4.05 ± 0.52 p value 0.067 < 0.001 < 0.001 < 0.001 0.002 0.008 Liver edge clarity 3 3.82 ± 0.54 3.70 ± 0.59 3.63 ± 0.58 3.77 ± 0.55 3.59 ± 0.65 3.70 ± 0.59 5 4.00 ± 0.54 4.03 ± 0.44 4.05 ± 0.56 4.11 ± 0.45 4.14 ± 0.44 4.02 ± 0.56 p value 0.065 0.005 0.004 0.003 < 0.001 0.016 Overall image quality 3 3.77 ± 0.62 3.70 ± 0.66 3.73 ± 0.56 3.66 ± 0.55 3.63 ± 0.56 3.70 ± 0.63 5 3.91 ± 0.48 4.14 ± 0.52 4.20 ± 0.22 4.18 ± 0.47 4.09 ± 0.55 4.11 ± 0.53 p value 0.159 0.004 < 0.001 < 0.001 0.002 0.008 Data are means ± standard deviations. AP Arterial phase,, HBP Hepatobiliary phase, PVP Portal venous phase, TP Transitional phase. Table 3 Image quality scores for PI- and ACS-accelerated HBP images Image artifacts Clarity of lesion margins Liver edge clarity Overall image quality PI 3.91 ± 0.61 4.05 ± 0.52 4.02 ± 0.56 4.11 ± 0.53 ACS 4.14 ± 0.55 4.32 ± 0.47 4.38 ± 0.49 4.39 ± 0.52 p value value 0.046 0.001 0.002 0.006 Data are means ± standard deviations. ACS Artificial intelligence-assisted compressed sensing, HBP Hepatobiliary phase, PI Parallel imaging. Table 4 Comparisons of SNR, CNR and CR between PI and ACS images SNR HBP CNR HBP CR HBP PI 52.58 ± 6.32 15.19 ± 5.46 0.215 ± 0.082 ACS 58.94 ± 11.99 20.36 ± 5.84 0.246 ± 0.077 p value 0.003 < 0.001 0.017 Data are means ± standard deviations. ACS Artificial intelligence-assisted compressed sensing, CNR Contrast-to-noise ratio, CR Contrast ratio, HBP Hepatobiliary phase, PI Parallel imaging, SNR Signal-to-noise ratio; Table 5 Detection rate of imaging features of 3-T and 5-T, as well as PI and ACS images Enhancing capsule Intralesion arterial vessels on AP Corona enhancement Peritumoral hypointensity on HBP 3-T-PI 16/27 (59.26%) 11/27 (40.74%) 3/27 (11.11%) 4/27 (14.81%) 5-T-PI 22/27 (81.48%) 13/27 (48.15%) 5/27 (18.52%) 5/27 (18.52%) 5-T-ACS − − − 8/27 (29.63%) p value 0.031 0.500 0.500 0.039 ACS Artificial intelligence-assisted compressed sensing, AP Arterial phase, HBP Hepatobiliary phase, PI Parallel imaging; Additional Declarations No competing interests reported. Supplementary Files supplementarymaterialsAB.docx Cite Share Download PDF Status: Published Journal Publication published 10 Apr, 2026 Read the published version in Abdominal Radiology → Version 1 posted Editorial decision: Revision requested 04 Jan, 2026 Reviews received at journal 27 Dec, 2025 Reviews received at journal 20 Dec, 2025 Reviewers agreed at journal 11 Dec, 2025 Reviewers agreed at journal 11 Dec, 2025 Reviewers agreed at journal 10 Dec, 2025 Reviewers agreed at journal 09 Dec, 2025 Reviewers invited by journal 08 Dec, 2025 Editor assigned by journal 05 Dec, 2025 Submission checks completed at journal 05 Dec, 2025 First submitted to journal 04 Dec, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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1","display":"","copyAsset":false,"role":"figure","size":72535,"visible":true,"origin":"","legend":"\u003cp\u003eFlowchart of the inclusion and exclusion criteria of the study. \u003cem\u003eHCC\u003c/em\u003e Hepatocellular carcinoma, \u003cem\u003eICC\u003c/em\u003e Intrahepatic cholangiocarcinoma, \u003cem\u003eLI-RADS\u003c/em\u003e Liver Imaging Reporting and Data System, \u003cem\u003eMRI\u003c/em\u003e Magnetic resonance imaging.\u003c/p\u003e","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/d603c247bbd14a33c674d0c0.png"},{"id":98426093,"identity":"f7952ac6-7ce3-41d5-9c56-32cb55156d6e","added_by":"auto","created_at":"2025-12-17 16:35:37","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":144064,"visible":true,"origin":"","legend":"\u003cp\u003eSNR, CNR and CR for 3-T and 5-T images. Data are means ± standard deviations. \u003cem\u003eCNR\u003c/em\u003e Contrast-to-noise ratio, \u003cem\u003eCR\u003c/em\u003e Contrast ratio, \u003cem\u003eeap\u003c/em\u003e Early arterial phase, \u003cem\u003ehbp\u003c/em\u003e Hepatobiliary phase, \u003cem\u003elap \u003c/em\u003eLate\u003cem\u003e \u003c/em\u003earterial phase, \u003cem\u003epre\u003c/em\u003e Precontrast, \u003cem\u003epvp\u003c/em\u003e Portal venous phase, \u003cem\u003eSNR\u003c/em\u003e Signal-to-noise ratio, \u003cem\u003etp\u003c/em\u003e Transitional phase.\u003c/p\u003e","description":"","filename":"floatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/24575e5bf977e699cbf8a6cf.png"},{"id":98427165,"identity":"0d61fadf-cb18-4c6c-8901-2b25ff2a325d","added_by":"auto","created_at":"2025-12-17 16:39:49","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":555368,"visible":true,"origin":"","legend":"\u003cp\u003eA 60-year-old man with HCC (Edmondson-Steiner grade Ⅱ-Ⅲ, microvascular invasion M0). Enhancing capsule cannot be seen in PVP (\u003cstrong\u003ea\u003c/strong\u003e) and TP (\u003cstrong\u003eb\u003c/strong\u003e) of 3-T Gd-EOB-DTPA-enhanced MRI, but it can be displayed in both PVP (\u003cstrong\u003ec\u003c/strong\u003e) and TP (\u003cstrong\u003ed\u003c/strong\u003e) of 5-T Gd-EOB-DTPA-enhanced MRI (white arrows). HCC Hepatocellular carcinoma, \u003cem\u003eMRI\u003c/em\u003e Magnetic resonance imaging. \u003cem\u003ePVP\u003c/em\u003e Portal venous phase, \u003cem\u003eTP\u003c/em\u003e Transitional phase;\u003c/p\u003e","description":"","filename":"floatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/cde9f41b44e9919a8c396399.png"},{"id":98427225,"identity":"595a86f9-aada-42df-a7fa-7f02f8414953","added_by":"auto","created_at":"2025-12-17 16:40:00","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":325835,"visible":true,"origin":"","legend":"\u003cp\u003eA 51-year-old man with hepatocellular carcinoma HCC (Edmondson-Steiner grade Ⅱ, microvascular invasion M1). Peritumoral hypointensity (white arrows) during HBP cannot be seen in the HBP image of PI sequence at 3 T (\u003cstrong\u003ea\u003c/strong\u003e) and with blurry display on HBP image of PI sequence at 5T (\u003cstrong\u003eb\u003c/strong\u003e), but it can be clearly displayed on ACS-accelerated HBP sequence at 5 T (\u003cstrong\u003ec\u003c/strong\u003e). \u003cem\u003eACS \u003c/em\u003eArtificial intelligence-assisted compressed sensing, \u003cem\u003eHBP\u003c/em\u003e Hepatobiliary phase, \u003cem\u003ePI \u003c/em\u003eParallel imaging.\u003c/p\u003e","description":"","filename":"floatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/09c2b4226dcdfd1a30b82f88.png"},{"id":98427951,"identity":"7279f0c6-1df9-4089-a76c-ebf8d49af08a","added_by":"auto","created_at":"2025-12-17 16:41:24","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":582299,"visible":true,"origin":"","legend":"\u003cp\u003eA 71-year-old man with hepatocellular carcinoma (Edmondson-Steiner grade Ⅱ-Ⅲ, microvascular invasion M1). Corona enhancement cannot be seen in early (\u003cstrong\u003ea\u003c/strong\u003e) and late AP imaging (\u003cstrong\u003eb\u003c/strong\u003e) at 3 T, but it can be displayed in both early (\u003cstrong\u003ec\u003c/strong\u003e) and late AP imaging (\u003cstrong\u003ed\u003c/strong\u003e) at 5 T (white arrows). \u003cem\u003eAP\u003c/em\u003eArterial phase.\u003c/p\u003e","description":"","filename":"floatimage5.png","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/4b267e6582f1420fae8efb41.png"},{"id":106808760,"identity":"12ab13f8-a6aa-4983-bc59-f4184ef5d030","added_by":"auto","created_at":"2026-04-13 16:01:01","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2938846,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/af0899f4-85fc-489d-b81c-241cac4e0857.pdf"},{"id":98426004,"identity":"7da2fa5b-e12a-491e-8586-c9ebb612a748","added_by":"auto","created_at":"2025-12-17 16:35:30","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":437648,"visible":true,"origin":"","legend":"","description":"","filename":"supplementarymaterialsAB.docx","url":"https://assets-eu.researchsquare.com/files/rs-8275712/v1/ca25c7ce5451d13d4c826cb0.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial results","fulltext":[{"header":"Purpose","content":"\u003cp\u003eHepatocellular carcinoma (HCC) is the most prevalent primary malignant tumor of the liver, characterized by a high incidence and mortality rate. Early diagnosis of HCC is crucial for timely treatment and improved prognosis. Research indicates that, compared to ultrasound and computed tomography, multiparametric magnetic resonance imaging (MRI) is more effective in detecting liver focal lesions with non-typical ultrasound/computed tomography features, thereby avoiding unnecessary biopsies due to its superior spatial resolution and optimal soft tissue contrast [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Contrast-enhanced MRI is widely used in detecting and characterizing liver lesions. The liver cell-specific contrast agent gadoxetic acid (Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid, Gd-EOB-DTPA) possesses a dynamic enhancement effect similar to that of extracellular contrast agents (ECAs) in arterial phase (AP) and portal venous phase (PVP), and is specifically absorbed by liver cells at hepatobiliary phase (HBP), making it a bifunctional contrast agent [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. It has been proved that Gd-EOB-DTPA-enhanced MRI significantly improved the detection rate and diagnostic accuracy of small (\u0026le;\u0026thinsp;20 mm) and subcentimeter (\u0026lt;10 mm) focal lesions [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eThe development of ultrahigh-field MRI has improved the limited spatial resolution and signal-to-noise ratio (SNR) of MRI. There is a growing interest in employing ultrahigh magnetic fields in whole-body MRI systems to explore their potential clinical applications. Recently, a 5-T whole-body MRI scanner has been introduced, which may offer advantages for abdominal imaging. Previous studies have shown that 5-T MRI provides superior image quality than 3-T, including higher SNR, better tumor identification, and clearer bile duct display in functional imaging and conventional plain scan [5\u0026thinsp;\u0026minus;\u0026thinsp;8].\u003c/p\u003e\u003cp\u003eOn the other hand, there is a trade-off between the acquisition time and spatial resolution of MRI [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. In order to obtain high spatial resolution images, the scanning time will increase and the SNR may decrease [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]. Thus, it is both crucial and challenging to conduct high-resolution liver MRI examinations with appropriate breath-holding times without compromising image quality [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. In comparison to current acceleration techniques such as parallel imaging (PI), the advent of artificial intelligence-assisted compressive sensing (ACS) has established a balance between scanning time and image quality [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]. Previous studies have demonstrated that ACS significantly reduced scanning time without sacrificing image quality when compared to PI, thereby enhancing efficiency and minimizing motion artifacts [12\u0026thinsp;\u0026minus;\u0026thinsp;14].\u003c/p\u003e\u003cp\u003eWe aimed to evaluate and compare image quality of plain and Gd-EOB-DTPA-enhanced MRI of HCC as well as the display of imaging features\u0026thinsp;\u0026minus;\u0026thinsp;including major and ancillary features of Liver Imaging Reporting and Data System (LI-RADS) version 2018 [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]\u0026thinsp;\u0026minus;\u0026thinsp;obtained at 5 and 3 T.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy design and participants\u003c/strong\u003e\u003cp\u003e This study is a single center, head to head controlled prospective study in accordance with the Declaration of Helsinki and has been approved by the Ethics Review Committee of the First Affiliated Hospital of the University of Science and Technology of China (2022KY-267). All patients provided written informed consent before the examination. Between September 2023 to December 2024, patients suspected of having HCC were enrolled. Inclusion criteria: (1)\u0026thinsp;\u0026ge;\u0026thinsp;18 years old; (2) Underwent 5-T gadoxetic acid-enhanced MRI. Exclusion criteria: (1) The patient didn't meet the LI-RADS v2018 criteria for high-risk populations;(2) Participants who withdrew from the trial and did not undergo the scheduled 3-T gadoxetic acid-enhanced MRI; (3) Not indicated for surgical resection [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e];(4) Final pathological results negative for HCC/ICC or without pathological. Finally, 28 patients were included in this study (Fig.\u0026nbsp;1).\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eImage acquisition\u003c/strong\u003e\u003cp\u003eAfter admission, all patients underwent MRI using a 5-T scanner (uMR Jupiter, United Imaging Healthcare, Shanghai, China) and a 3-T scanner (uMR 870, United Imaging Healthcare, Shanghai, China), both of them with a 24-channel body coil. The interval time between the 5-T and 3-T acquisitions was from two days to one week. All participants were informed of the potential risks associated with high-field MRI, including mild nausea, dizziness, headache, etc., as well as the purpose of the examination and the risk of contrast agent allergies. Respiratory coordination training was conducted before the scan to reduce the potential impact of respiratory artifacts. In order to purely compare effects of magnetic field strength on the image quality, same sequences and parameters were used at 3 and 5 T, and the spatial resolution was consistent in paired sequences. The imaging sequences included unenhanced axial three-dimensional (3D fast spoiled gradient-echo T1-weighted imaging (\u0026ldquo;quick-3D\u0026rdquo; in United Imaging Healthcare systems), axial fast spin echo T2-weighted imaging, diffusion-weighted imaging, and dynamic contrast enhanced scanning (Supplementary Tables S1 and S2).\u003c/p\u003e\u003cp\u003eFor pre- and post-contrast scanning including HBP imaging, quick-3D sequence was applied. The liver cell-specific contrast agent, gadoxetic acid (Gd-EOB-DTPA, Primovist; Bayer Healthcare, Berlin, Germany), was injected into the elbow vein at a rate of 1\u0026thinsp;\u0026minus;\u0026thinsp;2 mL/s using a high-pressure injector with a dose of 0.1 mL/kg, and then rinsed with 20 mL of saline. Early and late AP phase, PVP, transitional phase (TP), and HBP images were collected at 15 s, 60 s, 120 s, and 20 min after the injection of the contrast agent, respectively. During dynamic imaging, all quick-3D sequences were accelerated by PI method at 3 and 5 T. For HBP imaging, PI and ACS were both applied at 5-T.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eImage analysis\u003c/strong\u003e\u003cp\u003eAll sets of pre- and post-contrast images were transmitted to the postprocessing workstation (uWS-MR, United Imaging Healthcare, Shanghai, China) for image analysis and related parameter measurement. Two abdominal radiologists (with five and ten years of work experience) evaluated all images without knowing the patients information, pathological diagnosis, and field strength.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eSubjective evaluation\u003c/strong\u003e\u003cp\u003eThe two radiologists independently and subjectively evaluated pre- and post-contrast images at 5 and 3 T with respect to image artifacts, lesion edge clarity, liver edge clarity, and overall image quality. The scoring criteria for image artifacts and overall image quality adopt the 5-point Likert scale: 1 point, severe artifacts with image distortion, not diagnostic; 2 points, obvious artifacts, the image is blurry and affects diagnosis; 3 points, moderate artifacts, possibly diagnostic; 4 points, mild artifacts, good image quality; 5 points, no artifacts, excellent image quality. A 5-point scale was used to assess the edge clarity, 1\u0026thinsp;=\u0026thinsp;no visible boundary; 2\u0026thinsp;=\u0026thinsp;ill-defined boundary; 3\u0026thinsp;=\u0026thinsp;obscure boundary; 4\u0026thinsp;=\u0026thinsp;well defined boundary; 5\u0026thinsp;=\u0026thinsp;excellent boundary. The average subjective scores of the two radiologists were taken as the final scores.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eObjective evaluation\u003c/strong\u003e\u003cp\u003eThe two radiologists determined regions of interest (ROIs) independently. Four ROIs of fixed size (approximately 100 mm\u003csup\u003e2\u003c/sup\u003e) were placed at the second \u003cem\u003eporta hepatis\u003c/em\u003e level of each sequence to measure the signal intensity (SI) of the liver parenchyma in the left inner, left outer, right anterior, and right posterior lobes, avoiding blood vessels, bile ducts, and lesions. Then these four ROIs were copied to other sequences. To measure the SI of the lesion, the slice displaying the maximum cross-section area of the lesion, and its adjacent upper and lower slices were selected for ROI drawing. The lesion ROIs were determined on the three slices to cover the entire lesion as much as possible and avoid necrosis and bleeding. The SNR, contrast-to-noise ratio (CNR) and contrast ratio (CR) were calculated as follows:\u003c/p\u003e\u003cp\u003eSNR\u0026thinsp;=\u0026thinsp;SI\u003csub\u003eliver\u003c/sub\u003e / SD\u003csub\u003ebackground\u003c/sub\u003e\u003c/p\u003e\u003cp\u003eCNR = |SI\u003csub\u003eliver\u003c/sub\u003e - SI\u003csub\u003elesion\u003c/sub\u003e| / SD\u003csub\u003ebackground\u003c/sub\u003e\u003c/p\u003e\u003cp\u003eCR = |SI\u003csub\u003eliver\u003c/sub\u003e - SI\u003csub\u003elesion\u003c/sub\u003e| / SI\u003csub\u003eliver\u003c/sub\u003e + SI\u003csub\u003elesion\u003c/sub\u003e\u003c/p\u003e\u003cp\u003ewhere SI\u003csub\u003eliver\u003c/sub\u003e is the averaged SI within four liver parenchyma ROIs, SI\u003csub\u003elesion\u003c/sub\u003e is the averaged SI within three lesion ROIs, and SD\u003csub\u003ebackground\u003c/sub\u003e is the mean standard deviation (SD) of the four corners of the background on the same slice where the ROIs for normal liver tissues were placed (Supplementary Fig \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003e). The average objective scores of two radiologists were taken as the final scores.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eDisplay of HCC features\u003c/strong\u003e\u003cp\u003eThe two abdominal radiologists documented anatomical location and size of the target nodules together. They evaluated all LI-RADS major features (non-rim AP hyperenhancement, nonperipheral washout, enhancing capsule, and threshold growth), features of LI-M (rim AP hyperenhancement, peripheral washout, delayed central enhancement, targetoid restriction, and targetoid TP/HBP appearance), as well as specific ancillary features (nonenhancing capsule, nodule in nodule, mosaic structure, blood products in mass, and fat in mass), based on LI-RADS v2018. In addition, due to the important value of corona enhancement and peritumoral hypointensity on the HBP image [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e], as well as arterial vessels in HCC [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e], the two readers also evaluated these three features. When there was a discrepancy in image interpretation between two radiologists, the final decision was determined by a third radiologist, with 24 years of experience in liver imaging.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003cp\u003eSample size estimation for the paired design was conducted using PASS 2025, version 25.0.2 [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. The comparison was made using a one-sided, paired-difference \u003cem\u003et\u003c/em\u003e-test, with a type I error (α) rate of 0.05. The underlying standard deviation of the paired difference distribution was assumed to be 0.7. To detect a paired mean difference of 0.4 with 90% statistical power (1-β), the number of needed pairs was 28. Other statistical analyses were conducted using SPSS 26.0 software (IBM Corp., Armonk, New York, USA). Shapiro-Wilk test was used to perform normality test on the data. Continuous data are reported as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD and were compared using the paired Student\u0026rsquo;s \u003cem\u003et\u003c/em\u003e-test for a normal distribution and Wilcoxon signed rank test for a non-normal distribution. Count data are expressed as frequencies and percentages. Paired χ\u003csup\u003e2\u003c/sup\u003e test was used for comparisons between 3-T and 5-T scans and Cochran Q test was applied to compare three groups of data. Intraclass correlation coefficient (ICC) and Cohen κ were used to assess the consistency between the two readers. Agreement levels were interpreted as follows: not consistent (0.01\u0026thinsp;\u0026minus;\u0026thinsp;0.20); poor (0.21\u0026thinsp;\u0026minus;\u0026thinsp;0.40); moderate (0.41\u0026thinsp;\u0026minus;\u0026thinsp;0.60); good (0.61\u0026thinsp;\u0026minus;\u0026thinsp;0.80); and excellent (0.81\u0026thinsp;\u0026minus;\u0026thinsp;0.99). Two-tailed \u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.05 indicates statistically significant difference.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003ePatient characteristics\u003c/strong\u003e\u003cp\u003eWe included 28 high-risk HCC patients, comprising 24 males and 4 females, aged between 42 and 76 years, aged 60.07\u0026thinsp;\u0026plusmn;\u0026thinsp;9.07 years. All patients underwent surgery or biopsy to obtain pathological results and the results confirmed HCC. Among these patients, there were 27 cases of single lesion, and one case of two lesions. Furthermore, all enrolled patients successfully completed 3-T and 5-T MRI without complications and there were no patients whose images could not be evaluated due to severe respiratory artifacts. The patient clinical characteristics are presented in Table\u0026nbsp;1.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eSubjective evaluation and inter-observer consistency\u003c/strong\u003e\u003cp\u003eThe κ values of subjective scores from the two abdominal radiologists for all image sets obtained at 3 and 5 T ranged from 0.644 to 0.867, indicating good to excellent consistencies (Supplementary Tables S3 and S4).\u003c/p\u003e\u003cp\u003eThere was no statistically significant difference in all subjective scores of pre-contrast sequences and artifact scores of all sequences between 3 and 5 T. Compared with 3-T MRI, 5-T MRI had significantly higher scores in lesion edge clarity, liver edge clarity, and overall image quality for all post-contrast enhanced images (Table\u0026nbsp;2). Moreover, all subjective scores except image artifacts of ACS images were significantly higher than that of PI images for HBP imaging at 5 T (Table\u0026nbsp;3).\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eObjective evaluation and inter-observer consistency\u003c/strong\u003e\u003cp\u003eThe ICCs of SNR and CNR from the two abdominal radiologists for all image sets obtained at 3 and 5 T ranged from 0.730 to 0.930, indicating excellent consistencies (Supplementary Table S5). Summaries of SNR, CNR and CR of pre- and post-contrast enhanced quick-3D images at 3 and 5 T are shown in Fig.\u0026nbsp;2. There was no statistically significant difference between pre-contrast enhanced quick-3D images between different field strengths, while SNR, CNR and CR of post-contrast enhanced images of 5-T MRI were significantly higher. The SNR, CNR and CR of ACS-accelerated HBP sequence were also significantly superior to those of PI-accelerated sequence at 5 T (Table\u0026nbsp;4).\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eDetection of imaging features in HCC and non-HCC malignancy\u003c/strong\u003e\u003cp\u003eUsing LI-RADS v2018, 27 lesions were categorized as LR-5, and 2 lesions were categorized as LR-M. No lesion was categorized as LR-TIV by the two radiologists (Supplementary Table S6). Regarding the enhancing capsule, 16 cases were detected on PVP/TP images at 3 T, 22 cases were detected on PVP/TP images at 5 T (Fig.\u0026nbsp;3). The detection rate of enhancing capsule was significantly higher at 5 than at 3 T (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.031) (Table\u0026nbsp;5). On HBP images, 4 and 5 cases of peritumoral hypointensity were detected by PI-accelerated quick-3D at 3 and 5 T, respectively, and 8 cases were detected based on ACS-accelerated HBP imaging at 5 T, with a significant difference (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.039) (Fig.\u0026nbsp;4). The pairwise comparison showed that the detection rate of ACS sequence at 5 T was higher than that of PI sequence at 3 T (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.043) (Supplementary Table S7). For corona enhancement on AP images, 3 cases were observed at 3 T and 5 cases at 5 T (Fig.\u0026nbsp;5). Arterial vessels within the lesion were detected in 11 cases at 3, and 13 at 5 T (Fig.\u0026nbsp;6). The detection rate of other major/ancillary features and features of LI-M were consistent between the two field strengths (Supplementary Table S8). All enrolled patients were found to have liver lesions on their first examination, and the major feature of threshold growth was not applicable.\u003c/p\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this study, we compared 3-T and 5-T MRI in the diagnosis of HCC. The results showed that Gd-EOB-DTPA-enhanced MRI was superior at 5 T than at 3 T in terms of subjective evaluations of lesion edge clarity, liver edge clarity, and overall image quality, as well as considering the objective evaluations of SNR, CNR, and CR. In terms of displaying imaging features of HCC, 5-T MRI combined with ACS technology was superior to 3-T MRI. The combination of 5-T MRI and ACS technology can improve the quality of liver images and facilitate the display of HCC imaging features.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eInfluence of magnetic field strength on image quality\u003c/strong\u003e\u003cp\u003eThe image quality of MRI depends on factors such as SNR, CNR, spatial resolution, and artifacts. As the SI is linearly proportional to B\u003csub\u003e0\u003c/sub\u003e field strength, higher field could help improve SNR, CNR, and allow the application of high resolution imaging [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. However, at high magnetic field strengths (\u0026gt;\u0026thinsp;3 T), the risk of distortion increases due to the inhomogeneity of B\u003csub\u003e0\u003c/sub\u003e and B\u003csub\u003e1\u003c/sub\u003e fields, and the specific absorption rate increases, especially in abdominal imaging [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. Therefore, most ultrahigh-field studies were limited to neuroimaging and musculoskeletal imaging [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eRecently, the 5-T ultrahigh-field scanner has been put into clinical application, and studies have shown that both functional imaging such as diffusion-weighted and conventional plain scanning have obtained high-quality images of abdominal organs including liver, pancreas, kidneys [5\u0026thinsp;\u0026minus;\u0026thinsp;7,25]. These applications indicate that 5-T MRI has advantages on better SNR, CNR, CR and high spatial resolution imaging, giving the potential in displaying fine structures such as small tumors and complex anatomical structures, which can effectively reduce the risk of missed diagnosis [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eThis study demonstrated that the image quality of contrast-enhanced images at 5 T were significantly superior to that at 3 T. Previous \u003cem\u003ein vitro\u003c/em\u003e experiments have shown that native T1 relaxation time increased at higher field strengths, which may be the reason of improved contrast enhancement [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. As the field strength increases, due to the combined effect of protein binding, the increase in T1 value of tissues leads to a corresponding increase in relative contrast, ultimately resulting in a significant change in T1 relaxation value under high magnetic field strength [\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. Jiong et al. [\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e] set similar repetition time, echo time, and flip angle in sequences at 3 and 5 T and the results showed that the contrast between tumor and brain tissue in the half-dose contrast-enhanced images at 5 T was significantly higher than that in the full-dose contrast at 3 T. There was no statistically significant difference between the unenhanced images obtained at 3 and 5- T in this study, which may be due to the fact that the sequence parameters at 5 T were adjusted to be consistent with 3 T for comparison instead of being optimized to meet hardware limits.\u003c/p\u003e\u003cp\u003eTo mitigate industry-related bias, we applied several strategies. First, the 3-T and 5-T scanners were from the same manufacturer. Systematic errors have been minimized by the consistency in hardware and software. Second, same imaging sequences were used and parameters were set as identical as possible across different scanners. Besides, all image sets were reviewed on the same workstation and radiologists were blinded to any image information including the field strength. These strategies reinforced that image quality differences were attribute to field strength rather than industry-related confounders.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eAdvantages of ACS technology in contrast-enhanced sequences\u003c/strong\u003e\u003cp\u003eMRI has unique advantages in displaying the structure of lesions and abdominal organs. However, the drawbacks includes long scanning time and is prone to artifacts, which is especially inevitable in abdominal imaging [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. Common abdominal MRI artifacts include partial volume effects and motion/pulsation artifacts. In clinical settings, thin-slice and high spatial resolution imaging reduces local volume effects, and improves visibility and detection rates of small lesions, while increases scanning time and affects SNR. At present, commonly used acceleration techniques including CS, PI, and half-Fourier acquisition. However, when using high acceleration factors, these techniques may generate various artifacts and amplified noise during the image reconstruction process, thereby reducing image quality [\u003cspan additionalcitationids=\"CR32 CR33 CR34\" citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eACS follows the principles of half-Fourier, PI, and CS, and combines artificial intelligence modules in the reconstruction process [\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e], which reduces noise and artifacts, and corrects shortcomings of conventional acceleration techniques, providing reliable images for clinical diagnosis in a shorter time [\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e, \u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e]. Li et al. [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e] compared the ACS-accelerated single breath-hold T2-weighted images with traditional respiratory-triggered T2-weighted images, and showed that ACS provided better abdominal image quality, lesion detection rate, and greatly reduced the scanning time. In another nasopharyngeal study [\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e], ACS not only shortened the scanning time, but also improved image quality. Our study applied ACS to thin-slice iso-resolution HBP imaging and obtained similar results to previous studies that subjective scores, SNR, CNR and CR were significantly higher than PI-accelerated sequence scanned with thicker slices, indicating that ACS-accelerated HBP imaging could clearly display the liver and lesions without increasing scan time.\u003c/p\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eDetection of imaging features of HCC\u003c/strong\u003e\u003cp\u003eAccording to LI-RADS v2018 [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e], enhancing capsule is a smooth peripheral edge enhancement during PVP in ECA-enhanced MRI or PVP/TP in Gd-EOB-DTPA-enhanced MRI. Compared with ECA-enhanced MRI, the sensitivity for LR-5 is reduced when using Gd-EOB-DTPA-enhanced MRI [\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e], which is a major challenge as LI-RADS was originally designed for ECA-enhanced MRI [\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e], and the degree of tumor parenchymal enhancement in Gd-EOB-DTPA-enhanced MRI is lower [\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. As the SI of the background liver tissue gradually increases in Gd-EOB-DTPA-enhanced MRI, the enhanced capsule is usually masked by the background liver tissue, thereby reducing the detection rate of this feature [\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e]. In order to improve the diagnostic sensitivity of enhanced capsule, Chung et al. [\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e] proposed using subtraction method to increase the detection rate of enhanced capsule. Kim et al. [\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e] modified the scanning sequence by replacing the traditional single PVP with the double PVP, which also improved the detection rate of enhanced capsule. The results of our study showed that compared to 3-T MRI, 5-T MRI can improve the detection enhanced capsule, improving the accuracy of HCC diagnosis.\u003c/p\u003e\u003cp\u003eAs an ancillary feature of malignant tumor, corona enhancement has been shown to be an important predictor for HCC microvascular invasion [\u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e]. Although arterial vessels within tumors and peritumoral hypointensity on the HBP image are not major or ancillary features, they are crucial for HCC diagnosis, prognosis, and determination of treatment strategies [\u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e, \u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. Our study showed that the above features could be more clearly displayed at 5 T compared to 3 T, or ACS compared to PI sequences. The difference in detection rate of peritumoral hypointensity on the HBP image was significantly higher at 5-T ACS sequence, and the detection rates of corona enhancement and arterial vessels within tumors had also been improved with 5-T MRI, although the difference was not statistically significant. Since we had only two intrahepatic cholangiocarcinomas, the detection rate of LR-M features were consistent between 5-T and 3-T MRI. LR-M features including rim APHE, peripheral washout, delayed central enhancement and targetoid TP/HBP appearance can all be seen in these two cases.\u003c/p\u003e\u003cp\u003eThis study has several limitations. First, 5-T MRI is still in its early stages, and the development of technology makes it challenging to ensure the use of completely consistent software platforms and phased array circles to obtain 3-T and 5-T scans. In fact, phased array coils produced for systems with different magnetic field strengths will have different performance characteristics, which makes it challenging to compare image quality and SNR that rely solely on magnetic field strength. Second, our study population is relatively small. This may also be the reason why there is no statistical difference in partial imaging features between 3 and 5 T. Another limitation is that all subjects underwent 3-T scan at after the 5-T scan. Although there was an at least 48-hour interval between the two injections of contrast agent, residual contrast agent in tumors and organs may have influenced the image quality, SNR and CNR. However, our research results showed no significant difference in image quality between unenhanced 3-T and 5-T, suggesting that the impact of residual contrast agents on image quality may not interfere with subsequent image quality analysis. Finally, we did not include non-HCC lesions to evaluate diagnostic performance. However, the primary objective of this study was to compare HCC detection and image quality.\u003c/p\u003e\u003cp\u003eIn summary, 5-T MRI showed significant advantages over 3-T MRI with respect image quality and diagnosis of HCC. Furthermore, Gd-EOB-DTPA-enhanced MRI combined with ACS technology at 5 T obtained better image quality with same spatial resolution to display HCC imaging features, such as peritumoral hypointensity on HBP images, without increasing the scanning time.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003e3D\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Three-dimensional\u003c/p\u003e\n\u003cp\u003eACS \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Artificial intelligence-assisted compressive sensing\u003c/p\u003e\n\u003cp\u003eAP \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Arterial phase\u003c/p\u003e\n\u003cp\u003eCNR \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Contrast-to-noise ratio\u003c/p\u003e\n\u003cp\u003eCR \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Contrast ratio\u003c/p\u003e\n\u003cp\u003eECA\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Extracellular contrast agent\u003c/p\u003e\n\u003cp\u003eGd-EOB-DTPA \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid (gadoxetic acid)\u003c/p\u003e\n\u003cp\u003eHBP \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Hepatobiliary phase\u003c/p\u003e\n\u003cp\u003eHCC \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Hepatocellular carcinoma\u003c/p\u003e\n\u003cp\u003eLI-RADS \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Liver Imaging Reporting and Data System\u003c/p\u003e\n\u003cp\u003eMRI \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Magnetic resonance imaging\u003c/p\u003e\n\u003cp\u003ePI \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Parallel imaging\u003c/p\u003e\n\u003cp\u003ePVP \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Portal venous phase\u003c/p\u003e\n\u003cp\u003equick-3D\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;3D fast spoiled gradient-echo T1-weighted sequence\u003c/p\u003e\n\u003cp\u003eROI \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Region of interest\u003c/p\u003e\n\u003cp\u003eSD\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Standard deviation\u003c/p\u003e\n\u003cp\u003eSI \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Signal intensity\u003c/p\u003e\n\u003cp\u003eSNR \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Signal-to-noise ratio\u003c/p\u003e\n\u003cp\u003eTP \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Transitional phase\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Review Committee of the First Affiliated Hospital of the University of Science and Technology of China (approval number 2022KY-267, date of approval 27/10/2022).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll results of this study are presented in the manuscript in the form of tables, including scanning parameters. The datasets generated or analyzed during the study are available from the corresponding author upon reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eZhichao Feng, Runyu Tang and Xiaopeng Song were employees of United Imaging Healthcare throughout their involvement in the study. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study has received funding by National Key RandD Program of China (2019YFA0709300).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026apos; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eShaopeng LI: onceptualization, data curation, methodology, project administration, validation, writing \u0026ndash; original draft and review, and editing. Shuhang Liang, PhD: data curation, formal analysis, project administratio\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMengqiu Liu: data curation, methodology, validation. Xudan Chen: data curation, resources, validation\u003c/p\u003e\n\u003cp\u003eDawei YIN: data curation, project administration, validation. Zhichao Feng: investigation, methodology, software, writing\u0026mdash;review, and editing. Runyu Tang and Xiaopeng Song: formal analysis, methodology, software, writing\u0026ndash;review, and editing. Peng Wan: project administration, supervision, validation. Lianxin Liu: conceptualization, formal analysis, funding acquisition, supervision, visualization, writing\u0026ndash;review, and editing. Ying Liu: conceptualization, project administration, supervision, visualization, writing-original draft, review, and editing.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank all participants for their contribution to this study. We did not use Large Language Models for the conceptualization or creation of this manuscript.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eChartampilas E, Rafailidis V, Georgopoulou V et al (2022) Current imaging diagnosis of hepatocellular carcinoma. Cancers (Basel) 14:3997. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.3390/cancers14163997\u003c/span\u003e\u003cspan address=\"10.3390/cancers14163997\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMurakami T, Sofue K, Hori M (2022) Diagnosis of hepatocellular carcinoma using Gd-EOB-DTPA MR imaging. 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J Gastrointest Oncol 13:1248\u0026ndash;1254. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.21037/jgo-22-395\u003c/span\u003e\u003cspan address=\"10.21037/jgo-22-395\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eRhee H, Park YN, Choi JY (2024) Advances in understanding hepatocellular carcinoma vasculature: implications for diagnosis, prognostication, and treatment. Korean J Radiol 25:887\u0026ndash;901. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.3348/kjr.2024.0307\u003c/span\u003e\u003cspan address=\"10.3348/kjr.2024.0307\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cdiv class=\"SimplePara\"\u003eClinical characteristics of the patients\u003c/div\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"2\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eCharacteristics\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003eValues\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eNumber\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e28\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAge (years)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e60.07 \u0026plusmn; 9.07\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eSex\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eMale\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e24 (85.71%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eFemale\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e4 (14.29%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTumor size (cm)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5.41 \u0026plusmn; 2.60\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eEtiology of liver disease\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eHepatitis B\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e25 (89.29%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eHepatitis C\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e2 (7.14%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAlcoholic liver disease\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e1 (3.57%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eCirrhosis\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePresence\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e15 (53.57%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAbsence\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e13 (46.43%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eTumor markers\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eAlphafetoprotein (ng/mL)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026gt;200\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e8 (28.57%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e7\u0026thinsp;\u0026minus;\u0026thinsp;200\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e7 (25.00%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt; 7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e13 (46.43%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eCA19-9 (U/mL)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt; 43\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e23(82.14%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e43\u0026thinsp;\u0026minus;\u0026thinsp;100\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3 (10.72%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026gt;100\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e2 (7.14%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eNumber of lesions\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e1\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e27 (96.43%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e2\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e1 (3.57%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePer-patient final diagnosis\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eIntrahepatic cholangiocarcinoma\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e2 (6.90%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eHepatocellular carcinoma\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e27 (93.10%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eEdmondson-Steiner grade\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eⅠ\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3 (11.11%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eⅡ\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e10 (37.04%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eⅢ\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e13 (48.15%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eⅣ\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e1 (3.70%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"2\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eCA19-9\u003c/span\u003e Carbohydrateantigen19-9.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cdiv class=\"SimplePara\"\u003eImage quality scores for 3-T and 5-T images\u003c/div\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"8\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003eT\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003ePrecontrast\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003eEarly-AP\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003eLate-AP\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003ePVP\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003eTP\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003eHBP\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003eImage artifacts\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.75\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.82\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.91\u0026thinsp;\u0026plusmn;\u0026thinsp;0.58\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.63\u0026thinsp;\u0026plusmn;\u0026thinsp;0.49\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.73\u0026thinsp;\u0026plusmn;\u0026thinsp;0.65\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.75\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.89\u0026thinsp;\u0026plusmn;\u0026thinsp;0.49\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.95\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.07\u0026thinsp;\u0026plusmn;\u0026thinsp;0.50\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.79\u0026thinsp;\u0026plusmn;\u0026thinsp;0.53\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.95\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.91\u0026thinsp;\u0026plusmn;\u0026thinsp;0.61\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.088\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.226\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.095\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.085\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.083\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.140\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003eClarity of lesion margins\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.70\u0026thinsp;\u0026plusmn;\u0026thinsp;0.53\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.73\u0026thinsp;\u0026plusmn;\u0026thinsp;0.62\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.71\u0026thinsp;\u0026plusmn;\u0026thinsp;0.71\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.61\u0026thinsp;\u0026plusmn;\u0026thinsp;0.64\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.64\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.68\u0026thinsp;\u0026plusmn;\u0026thinsp;0.61\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.89\u0026thinsp;\u0026plusmn;\u0026thinsp;0.53\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.14\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.27\u0026thinsp;\u0026plusmn;\u0026thinsp;0.49\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.18\u0026thinsp;\u0026plusmn;\u0026thinsp;0.43\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.09\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.05\u0026thinsp;\u0026plusmn;\u0026thinsp;0.52\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.067\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.002\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.008\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003eLiver edge clarity\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.82\u0026thinsp;\u0026plusmn;\u0026thinsp;0.54\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.70\u0026thinsp;\u0026plusmn;\u0026thinsp;0.59\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.63\u0026thinsp;\u0026plusmn;\u0026thinsp;0.58\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.77\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.59\u0026thinsp;\u0026plusmn;\u0026thinsp;0.65\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.70\u0026thinsp;\u0026plusmn;\u0026thinsp;0.59\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.54\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.03\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.05\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.11\u0026thinsp;\u0026plusmn;\u0026thinsp;0.45\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.14\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.02\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.065\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.005\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.004\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.003\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.016\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e\u003cdiv class=\"SimplePara\"\u003eOverall image quality\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.77\u0026thinsp;\u0026plusmn;\u0026thinsp;0.62\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.70\u0026thinsp;\u0026plusmn;\u0026thinsp;0.66\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.73\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.63\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.70\u0026thinsp;\u0026plusmn;\u0026thinsp;0.63\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e5\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.91\u0026thinsp;\u0026plusmn;\u0026thinsp;0.48\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.14\u0026thinsp;\u0026plusmn;\u0026thinsp;0.52\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.20\u0026thinsp;\u0026plusmn;\u0026thinsp;0.22\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.18\u0026thinsp;\u0026plusmn;\u0026thinsp;0.47\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.09\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.11\u0026thinsp;\u0026plusmn;\u0026thinsp;0.53\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.159\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.004\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.002\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.008\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"8\"\u003eData are means\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviations. \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eAP\u003c/span\u003e Arterial phase,, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eHBP\u003c/span\u003e Hepatobiliary phase, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ePVP\u003c/span\u003e Portal venous phase, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eTP\u003c/span\u003e Transitional phase.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cdiv class=\"SimplePara\"\u003eImage quality scores for PI- and ACS-accelerated HBP images\u003c/div\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003eImage artifacts\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003eClarity of lesion margins\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003eLiver edge clarity\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003eOverall image quality\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePI\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e3.91\u0026thinsp;\u0026plusmn;\u0026thinsp;0.61\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.05\u0026thinsp;\u0026plusmn;\u0026thinsp;0.52\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.02\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.11\u0026thinsp;\u0026plusmn;\u0026thinsp;0.53\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eACS\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.14\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.32\u0026thinsp;\u0026plusmn;\u0026thinsp;0.47\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.38\u0026thinsp;\u0026plusmn;\u0026thinsp;0.49\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4.39\u0026thinsp;\u0026plusmn;\u0026thinsp;0.52\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.046\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.002\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.006\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"5\"\u003eData are means\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviations. \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eACS\u003c/span\u003e Artificial intelligence-assisted compressed sensing, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eHBP\u003c/span\u003e Hepatobiliary phase, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ePI\u003c/span\u003e Parallel imaging.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cdiv class=\"SimplePara\"\u003eComparisons of SNR, CNR and CR between PI and ACS images\u003c/div\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"4\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003eSNR\u003csub\u003eHBP\u003c/sub\u003e\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003eCNR\u003csub\u003eHBP\u003c/sub\u003e\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003eCR\u003csub\u003eHBP\u003c/sub\u003e\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003ePI\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e52.58\u0026thinsp;\u0026plusmn;\u0026thinsp;6.32\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e15.19\u0026thinsp;\u0026plusmn;\u0026thinsp;5.46\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.215\u0026thinsp;\u0026plusmn;\u0026thinsp;0.082\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003eACS\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e58.94\u0026thinsp;\u0026plusmn;\u0026thinsp;11.99\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e20.36\u0026thinsp;\u0026plusmn;\u0026thinsp;5.84\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.246\u0026thinsp;\u0026plusmn;\u0026thinsp;0.077\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.003\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026lt;\u0026thinsp;0.001\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.017\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"4\"\u003eData are means\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviations. \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eACS\u003c/span\u003e Artificial intelligence-assisted compressed sensing, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eCNR\u003c/span\u003e Contrast-to-noise ratio, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eCR\u003c/span\u003e Contrast ratio, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eHBP\u003c/span\u003e Hepatobiliary phase, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ePI\u003c/span\u003e Parallel imaging, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eSNR\u003c/span\u003e Signal-to-noise ratio;\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab5\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cdiv class=\"SimplePara\"\u003eDetection rate of imaging features of 3-T and 5-T, as well as PI and ACS images\u003c/div\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003eEnhancing capsule\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003eIntralesion arterial vessels on AP\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003eCorona enhancement\u003c/div\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003ePeritumoral hypointensity on HBP\u003c/div\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e3-T-PI\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e16/27 (59.26%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e11/27\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e(40.74%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e3/27 (11.11%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e4/27\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e(14.81%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e5-T-PI\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e22/27 (81.48%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e13/27\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e(48.15%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e5/27 (18.52%)\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e5/27\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e(18.52%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e5-T-ACS\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026minus;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026minus;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u0026minus;\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e8/27\u003c/div\u003e\u003cdiv class=\"SimplePara\"\u003e(29.63%)\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cdiv class=\"SimplePara\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ep\u003c/span\u003e value\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.031\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.500\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.500\u003c/div\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cdiv class=\"SimplePara\"\u003e0.039\u003c/div\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"5\"\u003e\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eACS\u003c/span\u003e Artificial intelligence-assisted compressed sensing, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eAP\u003c/span\u003e Arterial phase, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eHBP\u003c/span\u003e Hepatobiliary phase, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003ePI\u003c/span\u003e Parallel imaging;\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003cbr/\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"abdominal-radiology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"aima","sideBox":"Learn more about [Abdominal Radiology](http://link.springer.com/journal/261)","snPcode":"261","submissionUrl":"https://submission.springernature.com/new-submission/261/3","title":"Abdominal Radiology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Artificial intelligence, Carcinoma (hepatocellular), Gadolinium ethoxybenzyl DTPA, Liver neoplasms, Magnetic resonance imaging","lastPublishedDoi":"10.21203/rs.3.rs-8275712/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8275712/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e\u003cp\u003eWe aimed to evaluate the utility of 5-T gadoxetic acid (Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid, Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) by intraindividual comparison with 3-T, focusing on image quality and diagnosis of hepatocellular carcinoma (HCC).\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003eWe prospectively enrolled 28 patients with suspected HCC who underwent dynamic Gd-EOB-enhanced MRI using both 5-T and 3-T scanners. Artificial intelligence-assisted compressed sensing (ACS) and parallel imaging (PI) were both used for hepatobiliary phase (HBP) imaging at 5-T. Two radiologists performed the qualitative and quantitative assessments of image quality, and the evaluation of imaging features. Wilcoxon signed-rank, paired χ\u003csup\u003e2\u003c/sup\u003e, and Cochran Q test as well as intraclass correlation coefficients and Cohen κ were used.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eAll subjective image quality scores were rated as good to excellent. The subjective scores of contrast-enhanced phases at 5 T were higher than those at 3 T (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026le;\u0026thinsp;0.016) except for image artifacts. Quantitative measures were also greater at 5 T (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026le;\u0026thinsp;0.019). Subjective and quantitative assessment of HBP imaging were higher with ACS (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;\u0026le;\u0026thinsp;0.046). The detection rate of enhancing HCC capsule was higher at 5 T (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.031), as well as the peritumoral hypointensity on the HBP image at 5 T using ACS (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.039).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e\u003cp\u003eLiver dynamic Gd-EOB-DTPA-enhanced 5-T MRI demonstrated superior image quality for contrast-enhanced phases and greater sensitivity in detecting the HCC enhancing capsule compared with 3-T MRI. The integration of 5-T MRI and ACS technology holds the potential to further improve image quality and the assessment of imaging features.\u003c/p\u003e\u003ch2\u003eRelevance statement\u003c/h2\u003e\u003cp\u003eGd-EOB-DTPA-enhanced 5-T MRI provides promising potential for accurate HCC evaluation.\u003c/p\u003e","manuscriptTitle":"Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial results","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-12 08:33:41","doi":"10.21203/rs.3.rs-8275712/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2026-01-04T16:26:59+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-12-28T02:15:21+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-12-20T08:56:55+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"83746085585010873122501819297072344241","date":"2025-12-11T17:17:15+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"303446279196633986324245556438496712619","date":"2025-12-11T12:09:49+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"134915115589202818303357069058942882528","date":"2025-12-11T01:01:12+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"55762099286887839567061042576888412784","date":"2025-12-09T23:21:33+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-12-08T17:22:22+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-12-06T02:25:01+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-12-06T01:50:36+00:00","index":"","fulltext":""},{"type":"submitted","content":"Abdominal Radiology","date":"2025-12-04T05:29:44+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"abdominal-radiology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"aima","sideBox":"Learn more about [Abdominal Radiology](http://link.springer.com/journal/261)","snPcode":"261","submissionUrl":"https://submission.springernature.com/new-submission/261/3","title":"Abdominal Radiology","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"c8304db1-1305-4730-981f-192b22caa503","owner":[],"postedDate":"December 12th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2026-04-13T16:00:03+00:00","versionOfRecord":{"articleIdentity":"rs-8275712","link":"https://doi.org/10.1007/s00261-026-05500-6","journal":{"identity":"abdominal-radiology","isVorOnly":false,"title":"Abdominal Radiology"},"publishedOn":"2026-04-10 15:57:19","publishedOnDateReadable":"April 10th, 2026"},"versionCreatedAt":"2025-12-12 08:33:41","video":"","vorDoi":"10.1007/s00261-026-05500-6","vorDoiUrl":"https://doi.org/10.1007/s00261-026-05500-6","workflowStages":[]},"version":"v1","identity":"rs-8275712","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8275712","identity":"rs-8275712","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}