Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens

Herold BC; B C Herold; A Siston; Siston A; J Bremer; Bremer J; Kirkpatrick R; R Kirkpatrick; G Wilbanks; Wilbanks G; P Fugedi; Fugedi P; Peto C; C Peto; M. Cooper; Cooper M

doi:10.1128/aac.41.12.2776

Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens

Herold BC, B C Herold, A Siston, Siston A, J Bremer, Bremer J, Kirkpatrick R, R Kirkpatrick, G Wilbanks, Wilbanks G, P Fugedi, Fugedi P, Peto C, C Peto, M. Cooper, Cooper M

Antimicrobial agents and chemotherapy · 1997 · vol. 41(12) , pp. 2776–80 · doi:10.1128/aac.41.12.2776 · PMID:9420059 · PMC164209

Lab / animal OA: closed

📄 Open PDF View on PubMed View at publisher

⚙ AI-generated summary by qwen3.7-flash, 2026-09-05 ⓘ

Sulfated carbohydrate compounds that mimic heparan sulfate competitively inhibit adherence of herpes simplex virus, Chlamydia trachomatis, Neisseria gonorrhoeae, and HIV in primary human cultures.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.

My notes (saved in your browser only)

MeSH descriptors

Carbohydrates Sexually Transmitted Diseases, Bacterial Sexually Transmitted Diseases, Viral Sulfates Bacterial Adhesion Bacterial Adhesion Carbohydrates Chlamydia Infections Chlamydia Infections Chlamydia trachomatis Female Gonorrhea Gonorrhea HeLa Cells HeLa Cells HeLa Cells Herpes Simplex Herpes Simplex HIV Infections HIV Infections

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc: last seen: 2026-10-18T09:30:06.152893+00:00
pubmed: last seen: 2026-10-08T22:00:28.864438+00:00
unpaywall: last seen: 2026-10-22T06:24:31.118836+00:00