Drugs in the treatment of female infertility. Recent advances

Martin M. Quigley, M M Quigley
Drugs · 1986 · vol. 32(2) , pp. 169–177 · doi:10.2165/00003495-198632020-00004 · PMID:3527660 · W2003846000
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This review examines recent advances in pharmacological treatments for female infertility, focusing on ovulation-inducing drugs like clomiphene, hMG, and GnRH analogues for anovulation and assisted reproduction.

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Abstract

Involuntary infertility is an increasing problem in this era of delayed childbearing. Fortunately, many advances have been made recently in the medical and surgical treatment of infertility. This article reviews the principal aetiologies of infertility and their treatments, and focuses on the current and future uses of ovulation-inducing drugs and other infertility treatments. Proper diagnosis of anovulation and luteal phase dysfunction is discussed together with a description of conventional treatments with clomiphene and human menopausal gonadotrophins (hMG). Recent advances including the use of synthetic gonadotrophin hormone-releasing hormone (GnRH), purified human follicle stimulating hormone and a combination of GnRH and hMG are described, along with the application of the same agents for enhanced follicular recruitment for in vitro fertilisation. In addition, several promising future developments for pharmacological induction of normal ovulation are also discussed.

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Condition tags

infertility

MeSH descriptors

Infertility, Female Anovulation Anovulation Anovulation Bromocriptine Bromocriptine Female Fertility Agents, Female Fertility Agents, Female Fertilization in Vitro Hormones Hormones Humans Infertility, Female Infertility, Female Menstruation Disturbances Menstruation Disturbances Menstruation Disturbances

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