Clinical features and therapeutic response in patients with HIV and acute HCV coinfection: a cohort study

Clinical features and therapeutic response in patients with HIV and acute HCV coinfection: a cohort study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 25 September 2025 V1 Latest version Share on Clinical features and therapeutic response in patients with HIV and acute HCV coinfection: a cohort study Authors : Yeqiong Zhang [email protected] , Yunfei Xiao , Xingrong Zheng , Dabiao Chen , Peipei Wang , Xiaohua Yang , Xiaodi Li , Lili Li , Yue Zheng , Ying Zhang , and Zhanlian Huang Authors Info & Affiliations https://doi.org/10.22541/au.175877664.48456840/v1 127 views 102 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: To characterize the clinical features, genotype distribution, and treatment outcomes of acute hepatitis C virus (HCV) infection among people living with HIV (PLWH). Methods: A retrospective cohort study was conducted on 1,240 individuals with HIV from 2019 to 2024 to identify cases of acute HCV infection. Clinical data and treatment responses were analyzed. Results: 17 cases (1.37%) of acute HCV infection were identified, all of which were male, with a median age of 29 years. The primary risk factor for HCV infection was male-to-male sexual contact. The majority (76.5%) of patients were asymptomatic, with diagnoses made through routine LFTs. Marked elevations in alanine aminotransferase (ALT; >10 times the upper limit of normal [ULN] in 64.7%) and gamma-glutamyl transferase (GGT; median: 216 U/L) were observed. HCV genotype 1b was the predominant genotype (52.94%). Only 57.1% (n=8/14) of patients treated with direct-acting antiviral agents (DAAs) completed therapy, achieving a 100% sustained virological response. Conclusion: Acute HCV infection in PLWH is prevalent among young men who have sex with men (MSM), often presenting asymptomatically with significant hepatic injury. Routine HCV RNA screening is crucial for early diagnosis. DAAs demonstrated high efficacy, emphasizing the need for prompt treatment initiation. Supplementary Material File (manuscript.docx) Download 211.28 KB Information & Authors Information Version history V1 Version 1 25 September 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords hepatitis c virus human immunodeficiency virus infection virus classification Authors Affiliations Yeqiong Zhang [email protected] Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Yunfei Xiao Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Xingrong Zheng Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Dabiao Chen Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Peipei Wang Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Xiaohua Yang Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Xiaodi Li Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Lili Li Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Yue Zheng Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Ying Zhang Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Zhanlian Huang Third Affiliated Hospital of Sun Yat-Sen University View all articles by this author Metrics & Citations Metrics Article Usage 127 views 102 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Yeqiong Zhang, Yunfei Xiao, Xingrong Zheng, et al. Clinical features and therapeutic response in patients with HIV and acute HCV coinfection: a cohort study. Authorea . 25 September 2025. DOI: https://doi.org/10.22541/au.175877664.48456840/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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