Systematic ileostomy to avoid anastomotic leakage after posterior exenteration for advanced stage ovarian cancer? Retrospective cohort analysis.

This is a preprint and has not been peer reviewed. Data may be preliminary. Systematic ileostomy to avoid anastomotic leakage after posterior exenteration for advanced stage ovarian cancer? Retrospective cohort analysis. Abstract Objective: To compare the rate of anastomotic leakage in patients treated with posterior pelvic exenteration for advanced ovarian cancer, regardless of whether or not a systematic ileostomy was performed. Secondary objectives include surgical and oncologic outcomes. Method: This is an observational retrospective, multicenter study comparing two cohorts of patients managed for advanced stage ovarian cancer in two French cancer centers, from January 2019 to February 2023. All patients underwent cytoreductive surgery with colorectal resection and immediate colorectal anastomosis. Protective ileostomy could be performed in a center (center A) whereas it was never done in the other one (center B). Results: A total of 122 patients were included (54 patients in center A and 68 patients in center B). Protective ileostomy was performed in 64,9% of cases in center A. All seven anastomotic leakage concerned center B (10.3%; p=0.017). Occurrence of complications between center A and center B are similar (p=0.65). Grade 3 complications were more frequent in center B. We observed higher rate of incomplete cytoreduction in center A (p=0.04). Survival analyses do not show significative difference between center A group and center B group, for OS (p=0,32) and DFS (p=0,41). Conclusion: Performing a protective ileostomy is an effective way to prevent anastomotic leakage in cytoreduction surgery of advanced ovarian cancer. However, there is no clear evidence in term of long-term oncologic outcome and a broad policy of this procedure exposes to specific morbidity that can negatively affect the patient’s prognostic. Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Metrics & Citations Metrics Article Usage 168views 93downloads Citations Download citation Navid Mokarram Dorri, Clementine Bernard, Pierre Meeus, et al. Systematic ileostomy to avoid anastomotic leakage after posterior exenteration for advanced stage ovarian cancer? Retrospective cohort analysis.. Authorea. 05 June 2025. DOI: https://doi.org/10.22541/au.174913961.15390186/v1 DOI: https://doi.org/10.22541/au.174913961.15390186/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.