Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas

In: HEALTH OF WOMAN · 2016 · pp. 165–168 · doi:10.15574/hw.2016.112.165 · W2728416501
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Infertile women with non-operated ovarian endometriomas showed decreased biochemical, ultrasonographic, and histological indicators of ovarian reserve compared to controls.

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This study evaluated biochemical, sonographic, and histological markers of ovarian reserve in 63 infertile women of reproductive age presenting with non-operated ovarian endometriomas larger than three centimeters. The researchers compared these patients against a control group of thirty women with secondary tubal infertility who had undergone surgery, analyzing various hormonal and follicular indicators prior to intervention. The results demonstrated a significant decrease in all measured indicators of ovarian reserve among the women with endometriomas relative to the control group. This paper is centrally about endometriosis — specifically examining how non-operated endometriomas are associated with diminished ovarian reserve in infertile patients.

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Abstract

The objective: of the study was to investigate the indicators of ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas more than 3 cm in diameter. Patients and methods. It were examined 63 patients of reproductive age with ovarian endometriosis, including 33 with unilateral ones and 30 with bilateral. The control group consisted of 30 conditionally somatically healthy women of reproductive age with secondary tubal infertility, with regular ovulatory menstrual cycle. All the women were operated on. Prior to the surgery it were studied biochemical and sonographic markers of ovarian reserve, and after pathological study of operational materials – histological markers. Results. It was registered decrease in biochemical, ultrasonographic and histological indicators of ovarian reserve compared to control. Conclusion. The authors conclude that endometriosis directly affects ovarian reserve and ovarian reserve should be assessed not only after it, but before surgery in women with endometriomas and reproductive disorders. It is important to determine the tactics of their management. Key words: endometrioma, ovary, ovarian reserve, operation, Anti-Mьllerian hormone, inhibin B, FSH, estradiol, the number of antral follicles.
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- Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas HEALTH OF WOMAN. 2016.6(112):165–168; doi 10.15574/HW.2016.112.165 Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas Dubinina V. G., Nosenko О. М., Chuzhyk O. I., Grytsenko G. S. Odessa national medical University National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev The objective: of the study was to investigate the indicators of ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas more than 3 cm in diameter. Patients and methods. It were examined 63 patients of reproductive age with ovarian endometriosis, including 33 with unilateral ones and 30 with bilateral. The control group consisted of 30 conditionally somatically healthy women of reproductive age with secondary tubal infertility, with regular ovulatory menstrual cycle. All the women were operated on. Prior to the surgery it were studied biochemical and sonographic markers of ovarian reserve, and after pathological study of operational materials – histological markers. Results. It was registered decrease in biochemical, ultrasonographic and histological indicators of ovarian reserve compared to control. Conclusion. The authors conclude that endometriosis directly affects ovarian reserve and ovarian reserve should be assessed not only after it, but before surgery in women with endometriomas and reproductive disorders. It is important to determine the tactics of their management. Key words: endometrioma, ovary, ovarian reserve, operation, Anti-Mьllerian hormone, inhibin B, FSH, estradiol, the number of antral follicles. REFERENCES 1. Chuzhyk OI. 2015. Optymizatsiia peryoperatsiinoho vedennia zhinok reproduktyvnoho viku z endometrioidnymy kistamy yaiechnykiv. avtoref. dys. kand. med. nauk 14.01.01. Kyiv:20. 2. Jeon JH, Park SY, Lee SR et al. 2015. Serum Anti-Mьllerian Hormone Levels before Surgery in Patients with Ovarian Endometriomas Compared to Other Benign Ovarian Cysts. J Menopausal Med. 21(3):142-8. http://dx.doi.org/10.6118/jmm.2015.21.3.142. 3. Gleicher N, Weghofer A, Barad DH. 2011. Defining ovarian reserve to better understand ovarian aging. Reprod Biol Endocrinol. 9:23. 4. Toner JP, Seifer DB. 2013. Why we may abandon basal follicle-stimulating hormone testing: a sea change in determining ovarian reserve using antimullerian hormone. Fertil. Steril. 99:1825–30. http://dx.doi.org/10.1016/j.fertnstert.2013.03.001; PMid:23548941 5. Pacchiarotti A, Frati P, Milazzo GN et al. 2014. Evaluation of serum anti-Mullerian hormone levels to assess the ovarian reserve in women with severe endometriosis. Eur. J. Obstet. Gynecol. Reprod. Biol. 172:62-4. http://dx.doi.org/10.1016/j.ejogrb.2013.10.003. 6. Shebl O, Ebner T, Sommergruber M, Sir A et al. 2009. Anti-muellerian hormone serum levels in women with endometriosis: a case-control study. Gynecol. Endocrinol. 25(11):713-6. http://dx.doi.org/10.3109/09513590903159615. 7. Mostaejeran F, Hamoush Z, Rouholamin S. 2015. Evaluation of antimullerian hormone levels before and after laparoscopic management of endometriosis. Adv. Biomed. Res. 31(4):182. doi: 10.4103/2277-9175.164006. 8. Seyhan A, Ata B, Uncu G. 2015. The Impact of Endometriosis and Its Treatment on Ovarian Reserve. Semin Reprod Med. 33(6):422-428. http://dx.doi.org/10.1055/s-0035-1567820. 9. Haydardedeoglu B, Zeyneloglu HB. 2015. The impact of endometriosis on fertility. Womens Health (Lond Engl). 11(5):619-23. http://dx.doi.org/10.2217/whe.15.48. 10. Kitajima M, Defrиre S, Dolmans MM et al. 2011. Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis. Fertil. Steril. 96(3):685-91. http://dx.doi.org/10.1016/j.fertnstert.2011.06.064. 11. Zhang X, Li XH, Ma X et al. 2006. Redoxinduced apoptosis of human oocytes in resting follicles in vitro. J Soc Gynecol Investig. 13:451–8. http://dx.doi.org/10.1016/j.jsgi.2006.05.005; PMid:16879991 12. Chang HJ, Han SH, Lee JR et al. 2010. Impact of laparoscopic cystectomy on ovarian reserve: serial changes of serum anti-Mьllerian hormone levels Fertil Steril. 94:343-349. http://dx.doi.org/10.1016/j.fertnstert.2009.02.022. 13. Streuli I, de Ziegler D, Gayet V et al. 2012. In women with endometriosis anti-Mullerian hormone levels are decreased only in those with previous endometrioma surgery. Hum Reprod. 27(11):3294-303. http://dx.doi.org/10.1093/humrep/des274. 14. Somigliana E, Benaglia L, Vigano P et al. 2011. Surgical measures for endometriosis-related infertility: a plea for research. Placenta. 3:238-42. http://dx.doi.org/10.1016/j.placenta.2011.06.011. 15. de Carvalho BR, Rosa-e-Silva AC, Rosa-e-Silva JC et al. 2011. Anti-mьllerian hormone is the best predictor of poor response in ICSI cycles of patients with endometriosis. Clin Exp Obstet Gynecol. 38(2):119-22. 16. Falconer H, Sundqvist J, Gemzell-Danielsson K et al. 2009. IVF outcome in women with endometriosis in relation to tumour necrosis factor and Anti-Mьllerian hormone. Reprod Biomed Online 18(4):582-8. http://dx.doi.org/10.1016/S1472-6483(10)60138-1 17. Papaleo E, Ottolina J, Vigano P et al. 2011. Deep pelvic endometriosis negatively affects ovarian reserve and the number of oocytes retrieved for in vitro fertilization. Acta Obstet. Gynecol. Scand. 90(8):878–84. doi: 10.1111/j.1600-0412.2011.01161.x1

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