Oral beta-lactam step down in bacteremic E. coli urinary tract infections

Oral beta-lactam step down in bacteremic E. coli urinary tract infections | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Oral beta-lactam step down in bacteremic E. coli urinary tract infections Stephan Saad, Neil Mina, Colin Lee, Kevin Afra This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-61675/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 21 Oct, 2020 Read the published version in BMC Infectious Diseases → Version 2 posted 2 You are reading this latest preprint version Show more versions Abstract Background. Literature is scarce regarding oral step down to beta-lactams in bacteremic urinary tract infections. Oral fluoroquinolones are an accepted and common step down for bacteremic urinary tract infections; however, their use is associated with mounting safety concerns. We compared clinical cure in patients with E. coli bacteremic urinary tract infections who were stepped down to oral beta-lactams compared to oral fluoroquinolones. Methods. This multicentre retrospective cohort study included patients with first positive concurrent urine and blood cultures from January 2016 to December 2016. Patients were included if they received empiric intravenous beta-lactam therapy with step down to either oral beta-lactam or fluoroquinolone for treatment completion. The primary outcome was clinical cure. Secondary outcomes were length of hospitalization, all-cause mortality and C. difficile infection. Multivariate analysis and propensity score were used to control for confounding. Results. A total of 207 patients were identified with bacteremic E.coli urinary tract infections. Clinical cure was achieved in 72/77 (94%) in the oral beta-lactam group versus 127/130 (98%) in the oral fluoroquinolone group (absolute difference -4.2%, 95% confidence interval [CI] -10.3% to 1.9%, p=0.13). The adjusted odds ratio (OR) for clinical cure with oral beta-lactams was 0.31 (95% CI 0.05 – 1.90, p=0.21); propensity score adjusted analysis showed a similar result. There was no statistically significant difference in secondary outcomes. Conclusions. Oral beta-lactams appear to be a safe and effective step down option in bacteremic E. coli urinary tract infections compared to oral fluoroquinolones. Infectious Diseases oral step down antibiotics E. coli gram negative bacteremia urinary tract infection Summary Identifying effective alternatives to fluoroquinolones is important given mounting recent safety concerns. This retrospective study finds no difference in clinical outcomes for oral beta-lactam step down in bacteremic E. coli urinary tract infections compared to oral fluoroquinolones. Background Pyelonephritis is a common indication for antibiotic use with an incidence of 5-15 cases per 10,000 population [1]. E. coli is the most common causative organism, responsible for up to 80% of cases [1,2]. Treatment guidelines for pyelonephritis have historically favoured use of fluoroquinolones for oral therapy [3]. Oral beta-lactams are thought to be less effective. However, increasing resistance among uropathogens like E. coli to fluoroquinolones necessitate a reassessment of the role of oral beta-lactams in management of pyelonephritis. Moreover, regulatory agencies have released multiple recent warnings about the underappreciated harms of fluoroquinolones [4–10]. In pediatric patients with pyelonephritis, oral beta-lactams have already been established as a safe and effective treatment option. Canadian guidelines recommend that oral antibiotics be used as initial management of pyelonephritis, unless the child is toxic or has known structural urologic abnormalities [11]. Oral beta-lactam step down in pyelonephritis was reported routinely during randomized trials in the 1990’s evaluating pyelonephritis management in pregnancy [12–15]. Only one of these trials directly compared intravenous to oral beta-lactam therapy, finding no difference in clinical success; however, bacteremia was excluded [12]. Several further trials in non-pregnant women with pyelonephritis have shown equivalent efficacy of oral beta-lactams in step down compared with ongoing intravenous therapy [16,17]. Bacteremia was uncommon in these trials (20-25%), raising doubts about whether results could be extrapolated to patients with bacteremic urinary tract infections. Moreover, very little has been published in treatment of adult males with bacteremic pyelonephritis. We sought to compare the clinical outcomes of adult patients with urinary tract infection and E. coli bacteremia who received oral beta-lactam step down compared to oral fluoroquinolone following initial empiric intravenous beta-lactam therapy. Methods Study Design We conducted a multicentre retrospective cohort study including patients with first positive concurrent blood and urine cultures for E. coli from January 1, 2016 to December 31, 2016 within Fraser Health, which serves 1.8 million people in British Columbia, Canada. The study was approved by Fraser Health Research Ethics Board (FHREB File #: 2017-015). Patients with E. coli positive blood and urine cultures were identified from an electronic microbiology database. Patients were included in this study if they were 18 years or older and had both blood and urine cultures positive for E. coli within 72 hours of each other. Patients were only included if they received empiric intravenous beta-lactam therapy and followed by step down to oral beta-lactam or oral fluoroquinolone for treatment completion. Timing and agent of step down therapy was at the discretion of the treating physician. Patients who did not survive for at least 72 hours after first positive blood culture were excluded. Patients were also excluded for the following reasons: non-urinary source of E. coli bacteremia as documented by the treating physician; treatment for a concomitant infection; presence of complicated pyelonephritis identified within first 7 days of therapy (emphysematous pyelonephritis, renal parenchymal abscess, perinephric abscess, renal papillary necrosis); prostatitis; extended spectrum beta-lactamase producing, AmpC, or carbapenem-resistant E. coli ; HIV with CD4 <200; neutropenia with ANC <0.5; or renal transplant. Demographic, clinical and outcome data were acquired from electronic medical records. Charlson co-morbidity index and Pitt bacteremia score data were collected at baseline. Sepsis and septic shock was defined using the Sepsis-3 international consensus definitions [18]. Infections were classified as community-acquired healthcare-associated infections if any of the following criteria were met: Living in a long-term care facility or nursing home, receiving outpatient intravenous therapy within the past 30 days, attending a hospital or hemodialysis clinic within the past 30 days or being admitted for more than 2 days within the past 90 days. A full list of definitions can be found in Additional file 1. Outcome Measures The primary outcome was clinical cure defined by meeting all of the following criteria: resolution or improvement of symptoms during treatment, no recurrence of symptoms or signs of urinary tract infection within 30 days, and no discontinuation or change of treatment because of worsened or persistent symptoms or occurrence of adverse events. Secondary outcomes included length of hospitalization following first positive blood culture, all-cause mortality within 30 days of first positive blood culture, and C. difficile positive stool sample within 30 days of first positive blood culture. Microbiology Methods Blood and urine cultures were processed by a centralized clinical microbiology laboratory located within Fraser Health. Antibiotic susceptibility was determined by the Vitek 2 System (bioMérieux, Laval, Quebec). Clinical and Laboratory Standards Institute breakpoints were used to determine antimicrobial susceptibility breakpoints (2016 M100 26 th edition). Statistical Analysis Categorical variables were analyzed using Pearson chi-squared or Fisher’s exact test. Continuous variables were analyzed using Mann Whitney U test. Statistical significance for all tests was set at a p-value of less than 0.05. Association between antibiotic therapy (oral beta-lactam or oral fluoroquinolone) and clinical cure was modelled using logistic regression and expressed as odds ratios (ORs) and 95% confidence intervals (CI). Additional adjustment for covariates with a P value of <0.20 on univariate analysis were included in the adjusted logistic regression model. Further analysis using propensity score was performed to account for potential residual confounding. We constructed a propensity score for receiving antibiotic therapy (oral beta-lactam or oral fluoroquinolone) as the dependent variable using logistic regression modelling. Covariates included in generating the propensity score included age, sex, diabetes mellitus, chronic kidney disease, heart conditions, immune compromise, recurrent UTI risk factors (history of recurrent UTI, anatomical or functional urinary tract abnormalities, or nephrolithiasis), Pitt bacteremia score, sepsis, beta-lactam allergy, and duration of intravenous therapy. A final analysis using logistic regression to assess for association between antibiotic therapy and clinical cure was performed using propensity score as a single covariate. Statistical analyses were performed using STATA IC version 13.1 and RStudio version 1.2.503. Results There were 207 patients who met eligibility criteria during the study period. One hundred and thirty patients (62.8%) were stepped down to an oral fluoroquinolone, while 77 (37.2%) were stepped down to an oral beta-lactam. Baseline clinical and demographic data are presented in Table 1. Patients stepped down to an oral beta-lactam were more likely to have acquired the UTI in a community acquired health-care associated setting (26% vs 11.5%) and less likely in a community acquired setting (68.8% vs 84.6%). All other baseline factors were similar between groups, including indicators for severity of infection such as sepsis or septic shock, ICU admission, and Pitt bacteremia score. The median number of days of intravenous treatment was similar between patients stepped down to oral beta-lactam compared to oral fluoroquinolone (5 vs 5 days, p=0.20), as was oral treatment duration (7 vs 7 days, p=0.38), and total treatment duration (14 vs 14 days, p=0.91). The primary outcome of clinical cure was achieved in 127 patients (98%) in the oral fluoroquinolone group and in 72 patients (94%) in the oral beta-lactam group (absolute difference -4.2%, 95% CI, -10.3% to 1.9%, p=0.13) (Table 2). Unadjusted analysis demonstrated no significant difference between oral beta-lactam and oral fluoroquinolone groups for clinical cure (OR 0.34; 95% CI, 0.08 – 1.47, p=0.15) (Table 3). Results were similar using multivariate adjustment (adjusted OR, 0.31; 95% CI, 0.05 – 1.90, p=0.2) and propensity scoring adjustment (OR, 0.31; 95% CI, 0.07 – 1.38, p=0.12). Female sex was not associated with higher clinical cure (OR 2.49; 95% CI, 0.60 – 10.30, p=0.21). The median length of hospitalization was 6 days in both groups (p=0.43). There was one mortality in the oral fluoroquinolone group, and one case of C. difficile in each group; neither of these secondary outcomes were statistically significant. Patients stepped down to an oral fluoroquinolone were all prescribed ciprofloxacin (Table 4). Conversely, a variety of antibiotics were used as step down for those given an oral beta-lactam, including amoxicillin, amoxicillin-clavulanate, cephalexin, cefuroxime, and cefixime. Discussion Our results suggest that oral beta-lactams are a safe and effective step down for patients with E. coli bacteremic urinary tract infections. At baseline, the two treatment groups had similar co-morbidities, severity of infection and duration of intravenous treatment. In this population of bacteremic patients, there was no difference in rates of clinical cure or length of hospitalization. Approximately 30% of patients in our study were male with no significant difference in clinical cure rate compared to females. Mortality and C. difficile infection were infrequent occurrences, with no difference between the groups. This study isolated a group of bacteremic patients with pyelonephritis to demonstrate the suitability of oral beta-lactam step down and adds to a growing body of literature with similar conclusions. A randomized controlled trial by Sanchez et al compared daily intravenous ceftriaxone to single dose intravenous ceftriaxone followed by oral cefixime, both to total 10 days of treatment [16]. Their study included 144 women with uncomplicated pyelonephritis . E. coli was the responsible organism in nearly all cases and 25% of patients had bacteremia. There was no difference in clinical cure between groups (91% vs 92% respectively). Another randomized controlled trial by Monmaturapoj et al evaluated daily intravenous ceftriaxone to 3 days of intravenous ceftriaxone followed by oral cefditoren, both to total 10 days of treatment [17]. Their study included 82 patients with pyelonephritis, only three of whom were male. E. coli was identified in 84% of cases and 21% of patients had bacteremia. Again, no difference in clinical cure rate was found (95% vs 100% respectively). Both of these randomized controlled trials were limited by the small number of male patients and minority of cases with bacteremia. A recent observational study by Tamma et al showed similar 30-day mortality in a cohort of hospitalized patients with Enterobacteriaceae bacteremia who received oral step down therapy compared to ongoing intravenous therapy [19]. Nearly half the patients in their study were male. A wide range of infections were included, with urinary tract infection comprising 36.5%. However, fluoroquinolones were the most commonly used oral step down therapy (70%), while oral beta-lactams were only used in a minority (16.5%). This reflects the widespread practice of avoiding oral beta-lactams in step down therapy for gram negative bacteremia. Mercuro et al compared fluoroquinolones to beta-lactams in oral step down for Enterobacteriaceae bacteremia [20]. Over 50% of patients were male. E. coli was the dominant organism (71%), with approximately 70% having a urinary tract infection source. No difference in clinical success was noted between the two groups. However, their study included only admitted patients. Over 20% of patients in our study were managed as outpatients, without hospital admission. Furthermore, including a broad range of infections may mask differences between individual subgroups (e.g., urinary tract infections). As a homogenous patient population of bacteremic urinary tract infections our study is not affected by this limitation. A recent meta-analysis by Punjabi et al found no difference in all-cause mortality between oral beta-lactam and oral fluoroquinolones in step down of Enterobacteriaceae bacteremia [21]. Oral beta-lactams appeared to have higher rates of infection recurrence compared to fluoroquinolones. The authors hypothesize that under-dosing of beta-lactams may be contributing to this finding. Including a wide range of source infections confounds this interpretation. The impetus to limit fluoroquinolone prescribing is growing. Fluoroquinolone prescribing is an established risk for C. difficile infection, both at the individual and community level [22,23]. Multiple statements have been issued by Health Canada, the United States Food and Drug Administration, and the European Medicines Association warning about serious and underappreciated side effects [4–10]. For fluoroquinolone prescribing to be curbed, other therapeutic options with similar efficacy and improved safety profile need to be identified. Furthermore, despite the side effects of fluoroquinolones, they fulfil a critical role as oral therapy for difficult to treat gram-negative infections due to Pseudomonas or Acinetobacter . Limiting fluoroquinolone use to these infections where other suitable oral alternatives do not exist is prudent antimicrobial stewardship. Fluoroquinolones have long been regarded as an effective agent for bacteremic infections. Pharmacologic factors including high oral bioavailability, convenient dosing, and ability to attain dosing targets have supported this practice. This is supported by a large body of controlled literature and extensive real life clinical experience. Oral beta-lactams do not share the same historical confidence in serious invasive infections including bacteremia. Pharmacokinetic concerns including lower oral bioavailability and more frequent dosing are reason for pause. However, recent randomized controlled trials using oral beta-lactams in treatment of infective endocarditis and complex orthopedic infections challenge these historical dogmas [24,25]. Our study has several limitations. First, its retrospective design limits our ability to control for confounders to those that were collected. Second, selection bias could have been an issue, as unaccounted patient factors may have led a physician to choose a certain oral step down option, or not to step down to oral therapy at all. The use of propensity score analysis can partly account for this confounding. Third, some relevant outcomes may have been missed. Data were abstracted from the Health Authority electronic medical record, thus potentially relevant outcomes only captured in outpatient records were not accessible. Fourth, the convenience sample of one year resulted in a limited sample size. This study may be underpowered to identify a difference between treatment arms where one truly does exist. Fifth, our study excluded complicated cases (e.g., renal abscess) and prostatitis. Our results should not be extrapolated to the whole population of bacteremic urinary tract infections. Lastly, both groups received a median of 5 days of intravenous therapy and 14 days of total treatment. This longer treatment duration may have reduced the chance to find a difference between the groups. Conclusion Future research is needed to further establish the safety, efficacy, and optimal duration of oral step down therapy for bacteremic urinary tract infections, in particular with oral beta-lactams. While observational studies can corroborate our findings, randomized controlled trials would provide clinicians the greatest confidence in using oral beta-lactam therapy as step down for bacteremic urinary tract infections. In conclusion, oral beta-lactam step down in the setting of urinary tract infections with E. coli bacteremia had a similar clinical cure rate to that of oral fluoroquinolone step down. Given the potential adverse effects associated with fluoroquinolones, beta-lactams present a safe and efficacious alternative oral step-down agent. Abbreviations ORs, odds ratios CI, confidence intervals UTI, urinary tract infection ICU, intensive care unit COPD, chronic obstructive pulmonary disease IVDU, intravenous drug use CDI, Clostridioides difficile infection CA-UTI, catheter-associated urinary tract infection CKD, chronic kidney disease DM, diabetes mellitus IV, intravenous ER, extended release BID, two times a day TID, three times a day QID, four times a day Declarations Ethics approval and consent to participate: The study was approved by Fraser Health Research Ethics Board. All patient information was anonymized by assigning each subject a unique study code. Consent for publication: Not applicable. Availability of data and materials: The datasets used during the current study are available from the corresponding author on reasonable request. Competing interests: No competing interests to declare. Funding: This study was conducted with no external funding. Authors' contributions: SS and KA were responsible for formulating the research questions and the methodologic design of the study. SS, NM and KA were responsible for acquisition and interpretation of data. SS and KA performed statistical analyses. SS and KA drafted the manuscript. SS, CL, NM and KA provided critical revision of the manuscript for important intellectual content. KA supervised the project. All authors read and approved the final manuscript. Acknowledgements: None. References Czaja CA, Scholes D, Hooton TM, Stamm WE. Population-based epidemiologic analysis of acute pyelonephritis. Clin Infect Dis 2007;45:273–280. Zhanel GG, Hisanaga TL, Laing NM, et al. Antibiotic resistance in outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA). Int J Antimicrob Agents 2005;26:380–388. Gupta K, Hooton TM, Naber KG, et al. 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Baseline characteristics of patients Oral fluoroquinolone step down (n=130) Oral beta-lactam step down (n=77) p-value Age, median, years (IQR) 70.5 (56.25-80.75) 71 (54-80) 0.72 Sex 0.92 Female 92 (71) 54 (70) Male 38 (29) 23 (30) Comorbidities Diabetes Mellitus 29 (22) 20 (26) 0.55 Heart Conditions 75 (58) 43 (56) 0.8 Chronic Kidney Disease 10 (8) 3 (4) 0.28 Peripheral Vascular Disease 6 (5) 4 (5) 0.85 Asthma or COPD 14 (11) 7 (9) 0.7 Liver Cirrhosis 1 (1) 2 (3) 0.56 Recurrent UTI Risk factors 38 (29) 22 (29) 0.92 IVDU 5 (4) 0 (0) 0.16 Hepatitis C 1 (1) 1 (1) 1.0 HIV 0 (0) 0 (0) 1.0 Immunocompromised 5 (4) 4 (5) 0.65 Charlson comorbidity index, median (IQR) 1 (0-2) 1 (0-3) 0.96 Catheter associated UTI 6 (5) 4 (5) 0.85 Hospital admission 101 (78) 62 (81) 0.63 ICU admission 9 (7) 5 (6) 0.91 Sepsis 31 (25) 25 (33) 0.2 Septic shock 8 (6) 5 (6) 0.92 Pitt bacteremia score, median (IQR) 0.5 (0-1) 1 (0-1) 0.53 Site of acquisition 0.02 Community-acquired 110 (85) 53 (69) Community-acquired health-care associated 15 (12) 20 (26) Hospital-acquired 5 (4) 4 (5) Beta-lactam allergy 15 (12) 7 (9) 0.58 Inadequate empiric treatment 1 (1) 1 (1) 1.0 Stable at oral switch 125 (96) 74 (96) 0.99 Duration of intravenous treatment, median, days (IQR) 5 (3-7) 5 (3-7) 0.20 Duration of oral treatment, median, days (IQR) 7 (7-10) 7 (5.75-10) 0.38 Total treatment duration, median, days (IQR) 14 (12-14) 14 (11-14) 0.91 Data are number (percentage) of patients unless otherwise indicated. Abbreviations: COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; IVDU, intravenous drug use; UTI, urinary tract infection; Table 2. Thirty-day outcomes for patients Oral fluoroquinolone step down (n=130) Oral beta-lactam step down (n=77) p-value Primary Outcome Clinical cure 127 (98) 72 (94) 0.13 Secondary Outcomes 30-day mortality 1 (1) 0 (0) 0.43 CDI 1 (1) 1 (1) 1 Length of hospitalization, median, days (IQR) 6 (3.25-9) 6 (4-10) 0.43 Data are number (percentage) of patients unless otherwise indicated. Abbreviation: CDI, Clostridioides difficile infection. Table 3. Univariate and multivariate analysis for thirty-day clinical cure in E. coli bacteremic urinary tract infections. Unadjusted Analysis Multivariate Analysis Variable OR (95% CI) p-value OR (95% CI) p-value Age (per year) 0.98 (0.93-1.02) 0.30 … … Sex (female) 2.49 (0.60-10.30) 0.21 … … DM 0.29 (0.07-1.22) 0.09 0.50 (0.08-3.04) 0.45 CKD 0.18 (0.03-0.97) 0.046 0.28 (0.03-3.06) 0.30 Heart Conditions 0.18 (0.02-1.49) 0.11 0.38 (0.03-4.43) 0.44 Asthma/COPD 0.78 (0.09-6.69) 0.82 … … Immunocompromised 0.29 (0.03-2.68) 0.28 … … Recurrent UTI risk factors 0.12 (0.02-0.63) 0.01 0.15 (0.02-0.96) 0.045 CA-UTI 0.33 (0.04-2.99) 0.33 … … Charlson (per unit) 0.69 (0.52-0.92) 0.01 0.71 (0.41-1.21) 0.20 Pitt (per unit) 0.72 (0.49-1.04) 0.08 0.66 (0.39-1.10) 0.11 Sepsis 0.61 (0.14-2.62) 0.50 … … Septic Shock 0.45 (0.05-3.95) 0.47 … … ICU admission 0.49 (0.05-4.28) 0.52 … … Beta-lactam allergy 0.34 (0.06-1.77) 0.20 0.14 (0.02-1.14) 0.07 IV therapy duration 0.83 (0.67-1.03) 0.09 0.88 (0.65-1.18) 0.40 Total duration 1.01 (0.80-1.27) 0.96 … … Oral beta-lactam step down 0.34 (0.08-1.47) 0.15 0.31 (0.05-1.90) 0.21 Abbreviations: CA-UTI, catheter-associated urinary tract infection; CKD, chronic kidney disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; ICU, intensive care unit; IV, intravenous; OR, odds ratio; UTI, urinary tract infection. Table 4. Oral antibiotic step down regimens Antibiotic Regimen Frequency (%) Oral fluoroquinolone step down Ciprofloxacin 500 mg po BID 114 (87.7) (n=130) 500 mg po daily 5 (3.9) 250 mg po BID 5 (3.9) 750 mg po BID 2 (1.5) Ciprofloxacin ER 1000 mg po daily 3 (2.3) 500 mg po daily 1 (0.8) Oral beta-lactam step down Cefixime 400 mg po daily 24 (31.2) (n=77) Cephalexin 500 mg po QID 19 (24.7) 1000 mg po QID 1 (1.3) Amoxicillin-clavulanate 875 mg po BID 10 (13.0) 500 mg po TID 7 (9.1) 500 mg po BID 2 (2.6) Amoxicillin 500 mg po TID 5 (6.5) 500 mg po BID 2 (2.6) Cefuroxime 500 mg po BID 7 (9.1) Data are number (percentage) of patients unless otherwise indicated. Abbreviation: ER, extended release; BID, two times a day; TID, three times a day; QID, four times a day Supplementary Files Additionalfile1.docx Additional file 1 Word document format, .doc Definitions Definitions of terms used to collect data Cite Share Download PDF Status: Published Journal Publication published 21 Oct, 2020 Read the published version in BMC Infectious Diseases → Version 2 posted Submission checks completed at journal 10 Oct, 2020 Editorial decision: Accept 09 Oct, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-61675","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":3327778,"identity":"7294e32d-b126-473e-a807-ebbda32c02a4","order_by":0,"name":"Stephan Saad","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDklEQVRIiWNgGAWjYJACZhhD4gODBZBibAAh3IANSYvkDAYJErVI84C1QHThBPLzm489Lqi5wyDffvjhbZsaicS1s5sbmHl32DHwtx/AqsXgGFu68YxjzxgMzqQZW+cck0jcducgUMuZZAaJMwnYtbDxmEnzsB1mMGBIMJPOYQNquZEI1NJ2ACSC3WFt/N+kef4dZpDvf/5N2uIfshb+B9g9c4yHTZq37TADw40cM2nGNmQtEjgcdizN3Ji37zCPwY03xZa9fRLGIC0H555J5pG4gd0W+ebDzx7zfDssJ9+fvvHGj282sttupD988HaHnRx/P3ZbGMAxw8DAgyJ0AEMEi5ZRMApGwSgYBbgBAORaXHkLnyGrAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0001-5451-8938","institution":"The University of British Columbia","correspondingAuthor":true,"prefix":"","firstName":"Stephan","middleName":"","lastName":"Saad","suffix":""},{"id":3327779,"identity":"849631da-8a6a-46f3-8641-744b980d525c","order_by":1,"name":"Neil Mina","email":"","orcid":"","institution":"The University of British Columbia","correspondingAuthor":false,"prefix":"","firstName":"Neil","middleName":"","lastName":"Mina","suffix":""},{"id":3327780,"identity":"29eddcea-3399-49b9-87cf-fc71df665ddf","order_by":2,"name":"Colin Lee","email":"","orcid":"","institution":"University of British Columbia","correspondingAuthor":false,"prefix":"","firstName":"Colin","middleName":"","lastName":"Lee","suffix":""},{"id":3327781,"identity":"451afe75-11e3-4aa9-b9fa-68c3e4c7d163","order_by":3,"name":"Kevin Afra","email":"","orcid":"","institution":"University of British Columbia","correspondingAuthor":false,"prefix":"","firstName":"Kevin","middleName":"","lastName":"Afra","suffix":""}],"badges":[],"createdAt":"2020-08-18 11:25:45","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-61675/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-61675/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12879-020-05498-2","type":"published","date":"2020-10-21T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":15669293,"identity":"f2490371-a665-40f0-833c-2be0e226b098","added_by":"auto","created_at":"2021-11-18 13:52:35","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":304581,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-61675/v2/18a039b1-db43-445e-8f8e-19a316ae2cfc.pdf"},{"id":3035159,"identity":"4136303f-2773-4ac2-962c-30e006857045","added_by":"auto","created_at":"2020-10-16 23:10:18","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":20237,"visible":true,"origin":"","legend":"Additional file 1\nWord document format, .doc\nDefinitions\nDefinitions of terms used to collect data","description":"","filename":"Additionalfile1.docx","url":"https://assets-eu.researchsquare.com/files/rs-61675/v2/1cda8687aac9d8e3c3396d80.docx"}],"financialInterests":"","formattedTitle":"\u003cp\u003eOral beta-lactam step down in bacteremic \u003cem\u003eE. coli\u003c/em\u003e urinary tract infections\u003c/p\u003e","fulltext":[{"header":"Summary","content":"\u003cp\u003eIdentifying effective alternatives to fluoroquinolones is important given mounting recent safety concerns. This retrospective study finds no difference in clinical outcomes for oral beta-lactam step down in bacteremic \u003cem\u003eE. coli\u003c/em\u003e urinary tract infections compared to oral fluoroquinolones.\u003c/p\u003e"},{"header":"Background","content":"\u003cp\u003ePyelonephritis is a common indication for antibiotic use with an incidence of 5-15 cases per 10,000 population [1]. \u003cem\u003eE. coli\u003c/em\u003e is the most common causative organism, responsible for up to 80% of cases [1,2]. Treatment guidelines for pyelonephritis have historically favoured use of fluoroquinolones for oral therapy [3]. Oral beta-lactams are thought to be less effective.\u0026nbsp; However, increasing resistance among uropathogens like \u003cem\u003eE. coli\u003c/em\u003e to fluoroquinolones necessitate a reassessment of the role of oral beta-lactams in management of pyelonephritis.\u0026nbsp; Moreover, regulatory agencies have released multiple recent warnings about the underappreciated harms of fluoroquinolones [4\u0026ndash;10].\u003c/p\u003e\n\u003cp\u003eIn pediatric patients with pyelonephritis, oral beta-lactams have already been established as a safe and effective treatment option. Canadian guidelines recommend that oral antibiotics be used as initial management of pyelonephritis, unless the child is toxic or has known structural urologic abnormalities [11].\u003c/p\u003e\n\u003cp\u003eOral beta-lactam step down in pyelonephritis was reported routinely during randomized trials in the 1990\u0026rsquo;s evaluating pyelonephritis management in pregnancy [12\u0026ndash;15]. Only one of these trials directly compared intravenous to oral beta-lactam therapy, finding no difference in clinical success; however, bacteremia was excluded [12]. Several further trials in non-pregnant women with pyelonephritis have shown equivalent efficacy of oral beta-lactams in step down compared with ongoing intravenous therapy [16,17]. Bacteremia was uncommon in these trials (20-25%), raising doubts about whether results could be extrapolated to patients with bacteremic urinary tract infections. Moreover, very little has been published in treatment of adult males with bacteremic pyelonephritis.\u003c/p\u003e\n\u003cp\u003eWe sought to compare the clinical outcomes of adult patients with urinary tract infection and \u003cem\u003eE. coli\u003c/em\u003e bacteremia who received oral beta-lactam step down compared to oral fluoroquinolone following initial empiric intravenous beta-lactam therapy.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy Design\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe conducted a multicentre retrospective cohort study including patients with first positive concurrent blood and urine cultures for \u003cem\u003eE. coli\u003c/em\u003e from January 1, 2016 to December 31, 2016 within Fraser Health, which serves 1.8 million people in British Columbia, Canada. The study was approved by Fraser Health Research Ethics Board (FHREB File #: 2017-015).\u003c/p\u003e\n\u003cp\u003ePatients with \u003cem\u003eE. coli\u003c/em\u003e positive blood and urine cultures were identified from an electronic microbiology database. Patients were included in this study if they were 18 years or older and had both blood and urine cultures positive for \u003cem\u003eE. coli\u003c/em\u003e within 72 hours of each other. Patients were only included if they received empiric intravenous beta-lactam therapy and followed by step down to oral beta-lactam or oral fluoroquinolone for treatment completion. Timing and agent of step down therapy was at the discretion of the treating physician. Patients who did not survive for at least 72 hours after first positive blood culture were excluded.\u003c/p\u003e\n\u003cp\u003ePatients were also excluded for the following reasons: non-urinary source of \u003cem\u003eE. coli\u003c/em\u003e bacteremia as documented by the treating physician; treatment for a concomitant infection; presence of complicated pyelonephritis identified within first 7 days of therapy (emphysematous pyelonephritis, renal parenchymal abscess, perinephric abscess, renal papillary necrosis); prostatitis; extended spectrum beta-lactamase producing, AmpC, or carbapenem-resistant \u003cem\u003eE. coli\u003c/em\u003e; HIV with CD4 \u0026lt;200; neutropenia with ANC \u0026lt;0.5; or renal transplant.\u003c/p\u003e\n\u003cp\u003eDemographic, clinical and outcome data were acquired from electronic medical records. Charlson co-morbidity index and Pitt bacteremia score data were collected at baseline. Sepsis and septic shock was defined using the Sepsis-3 international consensus definitions [18]. Infections were classified as community-acquired healthcare-associated infections if any of the following criteria were met: Living in a long-term care facility or nursing home, receiving outpatient intravenous therapy within the past 30 days, attending a hospital or hemodialysis clinic within the past 30 days or being admitted for more than 2 days within the past 90 days. A full list of definitions can be found in Additional file 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOutcome Measures\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe primary outcome was clinical cure defined by meeting all of the following criteria: resolution or improvement of symptoms during treatment, no recurrence of symptoms or signs of urinary tract infection within 30 days, and no discontinuation or change of treatment because of worsened or persistent symptoms or occurrence of adverse events.\u003c/p\u003e\n\u003cp\u003eSecondary outcomes included length of hospitalization following first positive blood culture, all-cause mortality within 30 days of first positive blood culture, and \u003cem\u003eC. difficile\u003c/em\u003e positive stool sample within 30 days of first positive blood culture.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicrobiology Methods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBlood and urine cultures were processed by a centralized clinical microbiology laboratory located within Fraser Health. Antibiotic susceptibility was determined by the Vitek 2 System (bioM\u0026eacute;rieux, Laval, Quebec). Clinical and Laboratory Standards Institute breakpoints were used to determine antimicrobial susceptibility breakpoints (2016 M100 26\u003csup\u003eth\u003c/sup\u003e edition).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCategorical variables were analyzed using Pearson chi-squared or Fisher\u0026rsquo;s exact test. Continuous variables were analyzed using Mann Whitney U test. Statistical significance for all tests was set at a p-value of less than 0.05.\u003c/p\u003e\n\u003cp\u003eAssociation between antibiotic therapy (oral beta-lactam or oral fluoroquinolone) and clinical cure was modelled using logistic regression and expressed as odds ratios (ORs) and 95% confidence intervals (CI). Additional adjustment for covariates with a P value of \u0026lt;0.20 on univariate analysis were included in the adjusted logistic regression model.\u003c/p\u003e\n\u003cp\u003eFurther analysis using propensity score was performed to account for potential residual confounding. We constructed a propensity score for receiving antibiotic therapy (oral beta-lactam or oral fluoroquinolone) as the dependent variable using logistic regression modelling. Covariates included in generating the propensity score included age, sex, diabetes mellitus, chronic kidney disease, heart conditions, immune compromise, recurrent UTI risk factors (history of recurrent UTI, anatomical or functional urinary tract abnormalities, or nephrolithiasis), Pitt bacteremia score, sepsis, beta-lactam allergy, and duration of intravenous therapy. A final analysis using logistic regression to assess for association between antibiotic therapy and clinical cure was performed using propensity score as a single covariate. Statistical analyses were performed using STATA IC version 13.1 and RStudio version 1.2.503.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eThere were 207 patients who met eligibility criteria during the study period.\u0026nbsp; One hundred and thirty patients (62.8%) were stepped down to an oral fluoroquinolone, while 77 (37.2%) were stepped down to an oral beta-lactam. Baseline clinical and demographic data are presented in Table 1. Patients stepped down to an oral beta-lactam were more likely to have acquired the UTI in a community acquired health-care associated setting (26% vs 11.5%) and less likely in a community acquired setting (68.8% vs 84.6%). All other baseline factors were similar between groups, including indicators for severity of infection such as sepsis or septic shock, ICU admission, and Pitt bacteremia score. The median number of days of intravenous treatment was similar between patients stepped down to oral beta-lactam compared to oral fluoroquinolone (5 vs 5 days, p=0.20), as was oral treatment duration (7 vs 7 days, p=0.38), and total treatment duration (14 vs 14 days, p=0.91).\u003c/p\u003e\n\u003cp\u003eThe primary outcome of clinical cure was achieved in 127 patients (98%) in the oral fluoroquinolone group and in 72 patients (94%) in the oral beta-lactam group (absolute difference -4.2%, 95% CI, -10.3% to 1.9%, p=0.13) (Table 2).\u003c/p\u003e\n\u003cp\u003eUnadjusted analysis demonstrated no significant difference between oral beta-lactam and oral fluoroquinolone groups for clinical cure (OR 0.34; 95% CI, 0.08 \u0026ndash; 1.47, p=0.15) (Table 3). Results were similar using multivariate adjustment (adjusted OR, 0.31; 95% CI, 0.05 \u0026ndash; 1.90, p=0.2) and propensity scoring adjustment (OR, 0.31; 95% CI, 0.07 \u0026ndash; 1.38, p=0.12).\u0026nbsp; Female sex was not associated with higher clinical cure (OR 2.49; 95% CI, 0.60 \u0026ndash; 10.30, p=0.21).\u003c/p\u003e\n\u003cp\u003eThe median length of hospitalization was 6 days in both groups (p=0.43). There was one mortality in the oral fluoroquinolone group, and one case of \u003cem\u003eC. difficile\u003c/em\u003e in each group; neither of these secondary outcomes were statistically significant.\u003c/p\u003e\n\u003cp\u003ePatients stepped down to an oral fluoroquinolone were all prescribed ciprofloxacin (Table 4). Conversely, a variety of antibiotics were used as step down for those given an oral beta-lactam, including amoxicillin, amoxicillin-clavulanate, cephalexin, cefuroxime, and cefixime.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eOur results suggest that oral beta-lactams are a safe and effective step down for patients with \u003cem\u003eE. coli\u003c/em\u003e bacteremic urinary tract infections.\u0026nbsp; At baseline, the two treatment groups had similar co-morbidities, severity of infection and duration of intravenous treatment. In this population of bacteremic patients, there was no difference in rates of clinical cure or length of hospitalization. Approximately 30% of patients in our study were male with no significant difference in clinical cure rate compared to females. Mortality and \u003cem\u003eC. difficile\u003c/em\u003e infection were infrequent occurrences, with no difference between the groups.\u003c/p\u003e\n\u003cp\u003eThis study isolated a group of bacteremic patients with pyelonephritis to demonstrate the suitability of oral beta-lactam step down and adds to a growing body of literature with similar conclusions. A randomized controlled trial by Sanchez et al compared daily intravenous ceftriaxone to single dose intravenous ceftriaxone followed by oral cefixime, both to total 10 days of treatment [16]. Their study included 144 women with uncomplicated pyelonephritis\u003cem\u003e. E. coli\u003c/em\u003e was the responsible organism in nearly all cases and 25% of patients had bacteremia. There was no difference in clinical cure between groups (91% vs 92% respectively). Another randomized controlled trial by Monmaturapoj et al evaluated daily intravenous ceftriaxone to 3 days of intravenous ceftriaxone followed by oral cefditoren, both to total 10 days of treatment [17]. Their study included 82 patients with pyelonephritis, only three of whom were male. \u003cem\u003eE. coli \u003c/em\u003ewas identified in 84% of cases and 21% of patients had bacteremia. Again, no difference in clinical cure rate was found (95% vs 100% respectively). Both of these randomized controlled trials were limited by the small number of male patients and minority of cases with bacteremia.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eA recent observational study by Tamma et al showed similar 30-day mortality in a cohort of hospitalized patients with \u003cem\u003eEnterobacteriaceae\u003c/em\u003e bacteremia who received oral step down therapy compared to ongoing intravenous therapy [19]. Nearly half the patients in their study were male. A wide range of infections were included, with urinary tract infection comprising 36.5%. However, fluoroquinolones were the most commonly used oral step down therapy (70%), while oral beta-lactams were only used in a minority (16.5%). This reflects the widespread practice of avoiding oral beta-lactams in step down therapy for gram negative bacteremia.\u003c/p\u003e\n\u003cp\u003eMercuro et al compared fluoroquinolones to beta-lactams in oral step down for \u003cem\u003eEnterobacteriaceae\u003c/em\u003e bacteremia [20]. Over 50% of patients were male. \u003cem\u003eE. coli\u003c/em\u003e was the dominant organism (71%), with approximately 70% having a urinary tract infection source.\u0026nbsp; No difference in clinical success was noted between the two groups. However, their study included only admitted patients. Over 20% of patients in our study were managed as outpatients, without hospital admission. Furthermore, including a broad range of infections may mask differences between individual subgroups (e.g., urinary tract infections). As a homogenous patient population of bacteremic urinary tract infections our study is not affected by this limitation.\u003c/p\u003e\n\u003cp\u003eA recent meta-analysis by Punjabi et al found no difference in all-cause mortality between oral beta-lactam and oral fluoroquinolones in step down of \u003cem\u003eEnterobacteriaceae\u003c/em\u003e bacteremia [21]. Oral beta-lactams appeared to have higher rates of infection recurrence compared to fluoroquinolones. The authors hypothesize that under-dosing of beta-lactams may be contributing to this finding. Including a wide range of source infections confounds this interpretation.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe impetus to limit fluoroquinolone prescribing is growing. Fluoroquinolone prescribing is an established risk for \u003cem\u003eC. difficile\u003c/em\u003e infection, both at the individual and community level [22,23]. Multiple statements have been issued by Health Canada, the United States Food and Drug Administration, and the European Medicines Association warning about serious and underappreciated side effects [4\u0026ndash;10]. For fluoroquinolone prescribing to be curbed, other therapeutic options with similar efficacy and improved safety profile need to be identified. Furthermore, despite the side effects of fluoroquinolones, they fulfil a critical role as oral therapy for difficult to treat gram-negative infections due to \u003cem\u003ePseudomonas\u003c/em\u003e or \u003cem\u003eAcinetobacter\u003c/em\u003e. Limiting fluoroquinolone use to these infections where other suitable oral alternatives do not exist is prudent antimicrobial stewardship.\u003c/p\u003e\n\u003cp\u003eFluoroquinolones have long been regarded as an effective agent for bacteremic infections. Pharmacologic factors including high oral bioavailability, convenient dosing, and ability to attain dosing targets have supported this practice. This is supported by a large body of controlled literature and extensive real life clinical experience. Oral beta-lactams do not share the same historical confidence in serious invasive infections including bacteremia. Pharmacokinetic concerns including lower oral bioavailability and more frequent dosing are reason for pause. However, recent randomized controlled trials using oral beta-lactams in treatment of infective endocarditis and complex orthopedic infections challenge these historical dogmas [24,25].\u003c/p\u003e\n\u003cp\u003eOur study has several limitations. First, its retrospective design limits our ability to control for confounders to those that were collected. Second, selection bias could have been an issue, as unaccounted patient factors may have led a physician to choose a certain oral step down option, or not to step down to oral therapy at all. The use of propensity score analysis can partly account for this confounding. Third, some relevant outcomes may have been missed. Data were abstracted from the Health Authority electronic medical record, thus potentially relevant outcomes only captured in outpatient records were not accessible. Fourth, the convenience sample of one year resulted in a limited sample size. This study may be underpowered to identify a difference between treatment arms where one truly does exist. Fifth, our study excluded complicated cases (e.g., renal abscess) and prostatitis. Our results should not be extrapolated to the whole population of bacteremic urinary tract infections. Lastly, both groups received a median of 5 days of intravenous therapy and 14 days of total treatment. This longer treatment duration may have reduced the chance to find a difference between the groups.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eFuture research is needed to further establish the safety, efficacy, and optimal duration of oral step down therapy for bacteremic urinary tract infections, in particular with oral beta-lactams. While observational studies can corroborate our findings, randomized controlled trials would provide clinicians the greatest confidence in using oral beta-lactam therapy as step down for bacteremic urinary tract infections.\u003c/p\u003e\n\u003cp\u003eIn conclusion, oral beta-lactam step down in the setting of urinary tract infections with \u003cem\u003eE. coli\u003c/em\u003e bacteremia had a similar clinical cure rate to that of oral fluoroquinolone step down.\u0026nbsp; Given the potential adverse effects associated with fluoroquinolones, beta-lactams present a safe and efficacious alternative oral step-down agent.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eORs, odds ratios\u003c/p\u003e\n\u003cp\u003eCI, confidence intervals\u003c/p\u003e\n\u003cp\u003eUTI, urinary tract infection\u003c/p\u003e\n\u003cp\u003eICU, intensive care unit\u003c/p\u003e\n\u003cp\u003eCOPD, chronic obstructive pulmonary disease\u003c/p\u003e\n\u003cp\u003eIVDU, intravenous drug use\u003c/p\u003e\n\u003cp\u003eCDI, \u003cem\u003eClostridioides difficile\u003c/em\u003e infection\u003c/p\u003e\n\u003cp\u003eCA-UTI, catheter-associated urinary tract infection\u003c/p\u003e\n\u003cp\u003eCKD, chronic kidney disease\u003c/p\u003e\n\u003cp\u003eDM, diabetes mellitus\u003c/p\u003e\n\u003cp\u003eIV, intravenous\u003c/p\u003e\n\u003cp\u003eER, extended release\u003c/p\u003e\n\u003cp\u003eBID, two times a day\u003c/p\u003e\n\u003cp\u003eTID, three times a day\u003c/p\u003e\n\u003cp\u003eQID, four times a day\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eEthics approval and consent to participate: The study was approved by Fraser Health Research Ethics Board. All patient information was anonymized by assigning each subject a unique study code.\u003c/p\u003e\n\u003cp\u003eConsent for publication: Not applicable.\u003c/p\u003e\n\u003cp\u003eAvailability of data and materials: The datasets used during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003eCompeting interests: No competing interests to declare.\u003c/p\u003e\n\u003cp\u003eFunding: This study was conducted with no external funding.\u003c/p\u003e\n\u003cp\u003eAuthors' contributions: SS and KA were responsible for formulating the research questions and the methodologic design of the study. SS, NM and KA were responsible for acquisition and interpretation of data. SS and KA performed statistical analyses. SS and KA drafted the manuscript. SS, CL, NM and KA provided critical revision of the manuscript for important intellectual content. KA supervised the project. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003eAcknowledgements: None.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eCzaja CA, Scholes D, Hooton TM, Stamm WE. Population-based epidemiologic analysis of acute pyelonephritis. Clin Infect Dis 2007;45:273\u0026ndash;280.\u003c/li\u003e\n\u003cli\u003eZhanel GG, Hisanaga TL, Laing NM, et al. Antibiotic resistance in outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA). Int J Antimicrob Agents 2005;26:380\u0026ndash;388.\u003c/li\u003e\n\u003cli\u003eGupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 2011;52:e103-120.\u003c/li\u003e\n\u003cli\u003eU.S. Food \u0026amp; Drug Administration. FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together. 2016. http://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-advises-restricting-fluoroquinolone-antibiotic-use-certain. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eU.S. Food \u0026amp; Drug Administration. FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. 2016. http://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-updates-warnings-oral-and-injectable-fluoroquinolone-antibiotics. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eU.S. Food \u0026amp; Drug Administration. FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. 2018. http://www.fda.gov/drugs/drug-safety-and-availability/fda-reinforces-safety-information-about-serious-low-blood-sugar-levels-and-mental-health-side. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eU.S. Food \u0026amp; Drug Administration. FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. 2018. http://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-increased-risk-ruptures-or-tears-aorta-blood-vessel-fluoroquinolone-antibiotics. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eHealth Canada. Summary Safety Review - Oral FLUOROQUINOLONES - Assessing the Potential Risk of Retinal Detachment. 2016. https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/safety-reviews/summary-safety-review-oral-fluoroquinolones-assessing-potential-risk-retinal.html. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eHealth Canada. Summary Safety Review - Fluoroquinolones - Assessing the potential risk of persistent and disabling side effects. 2017. https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/safety-reviews/summary-safety-review-fluoroquinolones-assessing-potential-risk-persistent-disabling-effects.html. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eEuropean Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. 2019. https://www.ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containing-medicinal-products. Accessed 27 May 2019.\u003c/li\u003e\n\u003cli\u003eRobinson JL, Finlay JC, Lang ME, Bortolussi R, Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Community Paediatrics Committee. Urinary tract infections in infants and children: Diagnosis and management. Paediatr Child Health 2014;19:315\u0026ndash;325.\u003c/li\u003e\n\u003cli\u003eAngel JL, O\u0026rsquo;Brien WF, Finan MA, Morales WJ, Lake M, Knuppel RA. Acute pyelonephritis in pregnancy: a prospective study of oral versus intravenous antibiotic therapy. Obstet Gynecol 1990;76:28\u0026ndash;32.\u003c/li\u003e\n\u003cli\u003eMillar LK, Wing DA, Paul RH, Grimes DA. Outpatient treatment of pyelonephritis in pregnancy: a randomized controlled trial. Obstet Gynecol 1995;86:560\u0026ndash;564.\u003c/li\u003e\n\u003cli\u003eWing DA, Hendershott CM, Debuque L, Millar LK. A randomized trial of three antibiotic regimens for the treatment of pyelonephritis in pregnancy. Obstet Gynecol 1998;92:249\u0026ndash;253.\u003c/li\u003e\n\u003cli\u003eWing DA, Hendershott CM, Debuque L, Millar LK. Outpatient treatment of acute pyelonephritis in pregnancy after 24 weeks. Obstet Gynecol 1999;94:683\u0026ndash;688.\u003c/li\u003e\n\u003cli\u003eSanchez M, Collvinent B, Mir\u0026oacute; O, et al. Short-term effectiveness of ceftriaxone single dose in the initial treatment of acute uncomplicated pyelonephritis in women. A randomised controlled trial. Emerg Med J 2002;19:19\u0026ndash;22.\u003c/li\u003e\n\u003cli\u003eMonmaturapoj T, Montakantikul P, Mootsikapun P, Tragulpiankit P. A prospective, randomized, double dummy, placebo-controlled trial of oral cefditoren pivoxil 400mg once daily as switch therapy after intravenous ceftriaxone in the treatment of acute pyelonephritis. Int J Infect Dis 2012;16:e843-849.\u003c/li\u003e\n\u003cli\u003eSinger M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315:801\u0026ndash;810.\u003c/li\u003e\n\u003cli\u003eTamma PD, Conley AT, Cosgrove SE, et al. Association of 30-Day Mortality With Oral Step-Down vs Continued Intravenous Therapy in Patients Hospitalized With \u003cem\u003eEnterobacteriaceae\u003c/em\u003e Bacteremia. JAMA Intern Med 2019;179(3):316-323.\u003c/li\u003e\n\u003cli\u003eMercuro NJ, Stogsdill P, Wungwattana M. Retrospective analysis comparing oral stepdown therapy for \u003cem\u003eenterobacteriaceae\u003c/em\u003e bloodstream infections: fluoroquinolones versus \u0026beta;-lactams. Int J Antimicrob Agents 2018;51:687\u0026ndash;692.\u003c/li\u003e\n\u003cli\u003ePunjabi C, Tien V, Meng L, Deresinski S, Holubar M. Oral Fluoroquinolone or Trimethoprim-sulfamethoxazole vs. \u0026szlig;-lactams as Step-Down Therapy for \u003cem\u003eEnterobacteriaceae\u003c/em\u003e Bacteremia: Systematic Review and Meta-analysis. Open Forum Infectious Diseases 2019; 6:ofz364.\u003c/li\u003e\n\u003cli\u003eDeshpande A, Pasupuleti V, Thota P, et al. Community-associated Clostridium difficile infection and antibiotics: a meta-analysis. J Antimicrob Chemother 2013;68:1951\u0026ndash;1961.\u003c/li\u003e\n\u003cli\u003eDingle KE, Didelot X, Quan TP, et al. Effects of control interventions on Clostridium difficile infection in England: an observational study. Lancet Infect Dis 2017;17:411\u0026ndash;421.\u003c/li\u003e\n\u003cli\u003eIversen K, Ihlemann N, Gill SU, et al. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis. N Engl J Med 2019;380:415\u0026ndash;424.\u003c/li\u003e\n\u003cli\u003eLi H-K, Rombach I, Zambellas R, et al. Oral versus Intravenous Antibiotics for Bone and Joint Infection. N Engl J Med 2019;380:425\u0026ndash;436.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 11px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBaseline characteristics of patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;border: none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOral fluoroquinolone step down (n=130)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOral beta-lactam step down (n=77)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAge, median, years (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e70.5 (56.25-80.75)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e71 (54-80)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSex\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eFemale\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e92 (71)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e54 (70)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eMale\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e38 (29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e23 (30)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eComorbidities\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eDiabetes Mellitus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e29 (22)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e20 (26)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eHeart Conditions\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e75 (58)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e43 (56)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eChronic Kidney Disease\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e10 (8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e3 (4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ePeripheral Vascular Disease\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e6 (5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e4 (5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAsthma or COPD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e14 (11)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e7 (9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eLiver Cirrhosis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e2 (3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eRecurrent UTI Risk factors\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e38 (29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e22 (29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eIVDU\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0 (0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eHepatitis C\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eHIV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0 (0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0 (0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eImmunocompromised\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e4 (5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCharlson comorbidity index,\u003cbr\u003emedian (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (0-2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (0-3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCatheter associated UTI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e6 (5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e4 (5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eHospital admission\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e101 (78)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e62 (81)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eICU admission\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e9 (7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.91\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSepsis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e31 (25)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e25 (33)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSeptic shock\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e8 (6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ePitt bacteremia score, median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.5 (0-1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (0-1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSite of acquisition\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCommunity-acquired\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e110 (85)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e53 (69)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCommunity-acquired health-care associated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e15 (12)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e20 (26)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eHospital-acquired\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e4 (5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBeta-lactam allergy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e15 (12)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e7 (9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eInadequate empiric treatment\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eStable at oral switch\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e125 (96)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e74 (96)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eDuration of intravenous treatment,\u003cbr\u003emedian, days (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (3-7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (3-7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eDuration of oral treatment,\u003cbr\u003emedian, days (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e7 (7-10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e7 (5.75-10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 189.7pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.6099518459069%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eTotal treatment duration,\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003emedian, days (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 129pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.608346709470304%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e14 (12-14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e14 (11-14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.55pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.91\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eData are number (percentage) of patients unless otherwise indicated.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAbbreviations: COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; IVDU, intravenous drug use; UTI, urinary tract infection;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eTable 2.\u0026nbsp;\u003c/strong\u003eThirty-day outcomes for patients\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width: 467.4pt;border-collapse: collapse;border: none;\" width=\"623\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOral fluoroquinolone step down (n=130)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOral beta-lactam step down (n=77)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ePrimary Outcome\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eClinical cure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e127 (98)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e72 (94)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSecondary Outcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e30-day mortality\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0 (0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCDI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 191.15pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"40.93097913322632%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eLength of hospitalization, median, days (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 127.55pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.287319422150883%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e6 (3.25-9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"21.187800963081862%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e6 (4-10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.45pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.593900481540931%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eData are number (percentage) of patients unless otherwise indicated.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAbbreviation: CDI, \u003cem\u003eClostridioides difficile\u003c/em\u003e infection.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eTable 3.\u003c/strong\u003e Univariate and multivariate analysis for thirty-day clinical cure in \u003cem\u003eE. coli\u0026nbsp;\u003c/em\u003ebacteremic urinary tract infections.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;border: none;\" width=\"624\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 141.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"30.28846153846154%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eUnadjusted Analysis\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 163.2pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"34.93589743589744%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eMultivariate Analysis\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eVariable\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAge (per year)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.98 (0.93-1.02)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSex (female)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e2.49 (0.60-10.30)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eDM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.29 (0.07-1.22)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.50 (0.08-3.04)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCKD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.18 (0.03-0.97)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.046\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.28 (0.03-3.06)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eHeart Conditions\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.18 (0.02-1.49)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.38 (0.03-4.43)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAsthma/COPD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.78 (0.09-6.69)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eImmunocompromised\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.29 (0.03-2.68)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eRecurrent UTI risk factors\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.12 (0.02-0.63)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.15 (0.02-0.96)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.045\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCA-UTI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.33 (0.04-2.99)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCharlson (per unit)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.69 (0.52-0.92)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.71 (0.41-1.21)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ePitt (per unit)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.72 (0.49-1.04)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.66 (0.39-1.10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eSepsis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.61 (0.14-2.62)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n 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style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBeta-lactam allergy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.34 (0.06-1.77)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.14 (0.02-1.14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eIV therapy duration\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.83 (0.67-1.03)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.88 (0.65-1.18)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eTotal duration\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.01 (0.80-1.27)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026hellip;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 148.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"31.73076923076923%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eOral beta-lactam step down\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.15pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.34 (0.08-1.47)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.576923076923077%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.2pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"3.0448717948717947%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.71153846153846%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.31 (0.05-1.90)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.224358974358974%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;text-align: center;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAbbreviations: CA-UTI, catheter-associated urinary tract infection; CKD, chronic kidney disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; ICU, intensive care unit; IV, intravenous; OR, odds ratio; UTI, urinary tract infection.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eTable 4.\u0026nbsp;\u003c/strong\u003eOral antibiotic step down regimens\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width: 467.4pt;border-collapse: collapse;border: none;\" width=\"623\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAntibiotic\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eRegimen\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eFrequency (%)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eOral fluoroquinolone step down\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCiprofloxacin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po BID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e114 (87.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e(n=130)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po daily\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (3.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e250 mg po BID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (3.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e750 mg po BID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e2 (1.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCiprofloxacin ER\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1000 mg po daily\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e3 (2.3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po daily\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (0.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eOral beta-lactam step down\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCefixime\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e400 mg po daily\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e24 (31.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;(n=77)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCephalexin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po QID \u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e19 (24.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1000 mg po QID \u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1 (1.3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAmoxicillin-clavulanate\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e875 mg po BID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e10 (13.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po TID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e7 (9.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po BID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e2 (2.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAmoxicillin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po TID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5 (6.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po BID\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e2 (2.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"37.56019261637239%\"\u003e\n \u003cp style='margin: 0in 0in 0in 15.65pt;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 130.7pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"27.929373996789728%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCefuroxime\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 95.7pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.545746388443018%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e500 mg po BID\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.964686998394864%\"\u003e\n \u003cp style='margin: 0in;font-size:16px;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e7 (9.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eData are number (percentage) of patients unless otherwise indicated.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin: 0in;font-family: \"Times New Roman\", serif;line-height: 32px;'\u003e\u003cspan style=\"font-size: 11px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eAbbreviation: ER, extended release; BID, two times a day; TID, three times a day; QID, four times a day\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"oral step down, antibiotics, E. coli, gram negative bacteremia, urinary tract infection","lastPublishedDoi":"10.21203/rs.3.rs-61675/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-61675/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground. \u003c/strong\u003eLiterature is scarce regarding oral step down to beta-lactams in bacteremic urinary tract infections. Oral fluoroquinolones are an accepted and common step down for bacteremic urinary tract infections; however, their use is associated with mounting safety concerns. We compared clinical cure in patients with \u003cem\u003eE. coli\u003c/em\u003e bacteremic urinary tract infections who were stepped down to oral beta-lactams compared to oral fluoroquinolones.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods.\u003c/strong\u003e This multicentre retrospective cohort study included patients with first positive concurrent urine and blood cultures from January 2016 to December 2016. Patients were included if they received empiric intravenous beta-lactam therapy with step down to either oral beta-lactam or fluoroquinolone for treatment completion. The primary outcome was clinical cure. Secondary outcomes were length of hospitalization, all-cause mortality and \u003cem\u003eC. difficile \u003c/em\u003einfection. Multivariate analysis and propensity score were used to control for confounding.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults.\u003c/strong\u003e A total of 207 patients were identified with bacteremic \u003cem\u003eE.coli \u003c/em\u003eurinary tract infections. Clinical cure was achieved in 72/77 (94%) in the oral beta-lactam group versus 127/130 (98%) in the oral fluoroquinolone group (absolute difference -4.2%, 95% confidence interval [CI] -10.3% to 1.9%, p=0.13). The adjusted odds ratio (OR) for clinical cure with oral beta-lactams was 0.31 (95% CI 0.05 – 1.90, p=0.21); propensity score adjusted analysis showed a similar result. There was no statistically significant difference in secondary outcomes.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions. \u003c/strong\u003eOral beta-lactams appear to be a safe and effective step down option in bacteremic \u003cem\u003eE. coli\u003c/em\u003e urinary tract infections compared to oral fluoroquinolones.\u003c/p\u003e","manuscriptTitle":"Oral beta-lactam step down in bacteremic E. coli urinary tract infections","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-10-16 23:10:16","doi":"10.21203/rs.3.rs-61675/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"checksComplete","content":"","date":"2020-10-10T12:00:00+00:00","index":"","fulltext":""},{"type":"decision","content":"Accept","date":"2020-10-09T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-08-26 21:23:30","doi":"10.21203/rs.3.rs-61675/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-09-23T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-19T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nOral beta-lactam step down in bacteremic E. coli urinary tract infections\n\nThis is a well-conceived manuscript.\nMinor comments are attached therein in the edited manuscript.\n\nAll the best.\n\n\n\n\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorInvitedReview","content":"","date":"2020-09-11T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after discretionary revisions\nForm responses:\n---\n\nComments to Author:\n---\nPlease include all comments for the authors in this box rather than uploading your report as an attachment. Please only upload as attachments annotated versions of manuscripts, graphs, supporting materials or other aspects of your report which cannot be included in a text format.\nPlease overwrite this text when adding your comments to the authors.\np 5 Line 95: Add the ethics approval number of the study.\np 6 Line 128: Add the year of the CLSI guidelines that were used in the study.\np 8 Line 154: Please include the criteria that was used to decide on the stepped down to an oral beta-lactam.\np 8 Line 175: Please clarify how the distribution/allocation of the variety of antibiotics for step down were decided on among the patients in the study.\nPlease write the family name: Enterobacteriacea also in italics.\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-10T12:00:00+00:00","index":3,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-09-09T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-08-26T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-08-25T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-08-18T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2020-08-17T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-08-17T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-08-17T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-infectious-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"infd","sideBox":"Learn more about [BMC Infectious Diseases](http://bmcinfectdis.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/infd","title":"BMC Infectious Diseases","twitterHandle":"#bmcinfectdis","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"019c4f60-198a-4394-bc8d-0a0a25800ce0","owner":[],"postedDate":"October 16th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":807192,"name":"Infectious Diseases"}],"tags":[],"updatedAt":"2020-10-25T15:02:42+00:00","versionOfRecord":{"articleIdentity":"rs-61675","link":"https://doi.org/10.1186/s12879-020-05498-2","journal":{"identity":"bmc-infectious-diseases","isVorOnly":false,"title":"BMC Infectious Diseases"},"publishedOn":"2020-10-21 12:00:00","publishedOnDateReadable":"October 21st, 2020"},"versionCreatedAt":"2020-10-16 23:10:16","video":"","vorDoi":"10.1186/s12879-020-05498-2","vorDoiUrl":"https://doi.org/10.1186/s12879-020-05498-2","workflowStages":[]},"version":"v2","identity":"rs-61675","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-61675","identity":"rs-61675","version":["v2"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}