COMBINED USE OF MIFEPRISTONE PROTESTOGEN AND ANDROGEN IN TREATING 56 CASES OF CLIMACTERIC DYSFUNCTIONAL UTERINE BLEEDING

Objective To explore the curative effects of the combined use of mifepristone,protestogen and androgen on climacteric dysfunctional uterine bleeding.Methods 10mg Mifepristone was used daily 3 days after menses and dignostic curretage,3 month as a course.10mg medroxyprogesterone a day and 10mg methyltestosterone a day were added to the above therapy 10 days before the course ended.Dysfunctiond uterine bleeding and endometrial pathological changes were observed during the drug-admistering period and after the course of treatment ended.The relationship between menopause and the age or the course of treatment were studied.Results All patients showed menopause.90% of the patients got normal menses or the menses with less bleeding.No massive hernorrhage occurred after the treatments.Endometria recovered well and no hyperplasia take place.Of the 56 patients,33 cases successfully got induced menopause.The frequency of the course of treatment is in positive proportion to the number of cases of menopause,while in negative proportion to age.Hysteromyoma shrank to different extent.No side effects were discovered.Conclusion Combined use of mifepristone protestogen and androgen in treating climateric dysfunctional uterine bleeding can prevent endometrial hyperplasia,reduce massive hemorrhage,control hysteromyoma and effectively induce menopause.