Histological Evaluation of Implantation Deficit in Experimentally Induced Endometriosis Model of Rats

Background: Experimental animal models are important in understanding human endometriotic disease.Aims: This study aims to describe factors influencing the implantation deficit in experimental endometriosis.Material and Method: Decidua reaction were detected in surgical endometriosis induction group (n=20), sham operated (n=10) and non-operated control (n=10) groups and studied with routine light microscopic, electron microscopic and immunohistochemical techniquesas well as histologic, morphometric and biochemical analysis. Results: Decidualisation and pinopode expression of eutopic endometrium in surgically induced endometriosis relatively decreased and adequate endometrial morphology may not always display normal endometrial receptivity. Although mitotic figures were described, study groups revealed statisticallydifferences in morphometry.Conclusions: Uterine receptivity defects are regulated differently while other alternative mechanisms effecting endometrial receptivity sustained. In addition, unsignificant differences of immunohistochemical expressions are non-descriptive due to the antibodies used for uterine receptivity in experimental endometriosis. Yet, morphometry may pioneer novel ultrasonographic modules in future