Sociodemographic, Clinical and Biochemical Factors Associated With the Glomerular Filtration Rate in Patients Newly Admitted to Hemodialysis in Sus

Background: Among the chronic conditions with the greatest evidence of a multifactorial nature, both in terms of etiology and progression, Chronic Kidney Disease (CKD) stands out. The present study aims to analyze the relationship between the Glomerular Filtration Rate (GFR) and the biochemical and sociodemographic parameters in individuals recently admitted to hemodialysis. Methods: This is a baseline cross-sectional design of the Nephrology Service of the health microregion of Viçosa, Minas Gerais, Brazil. Descriptive, univariate and multiple linear regression analyzes were performed. The Kolmogorov-Smirnov test was used to test the normality of continuous variables. For numeric variables, Student's t and Mann Whitney test were used. All analyzes were performed using IBM SPSS Statistics 23.0 Software. Results: Data from 422 patients were included. The mean age at the onset of HD was 64.02 ± 15.21 years. Chronic hypertensive kidney disease represented 33.4% of cases with varied etiology. The average Glomerular Filtration Rate (GFR), calculated using the CKD-EPI formula, was 10.13 ml/min/1.73m² and the average survival time was 52.06 months (± 49.91%). Based on the evaluation of laboratory data, the averages that were not normal according to the recommendations for these patients were serum calcium, hemoglobin, hematocrit, serum albumin and pre-dialysis urea. Based on the results of the univariate analysis, the following variables were included in the multiple linear regression model: gender, marital status, age, nPCR, glucose, albumin, ferritin, and PTH. According to multivariate analysis, gender, marital status, nPCR, glucose and PTH were independently associated with GFR. Conclusion: CKD is increasingly highlighted nowadays because it is a CNCD with a high prevalence of hospitalizations and mortality due to its multifactorial and progressive nature. Therefore, by analyzing the relationship between GFR and biochemical and sociodemographic parameters in individuals newly admitted to HD, the present study allows further insights into the mechanisms that will translate into causalities and ways to establish a better prognosis.