Intravenous Uptake of NMN is Safely Metabolize and Increases NAD+ Levels in Healthy Subjects

Abstract Increasing nicotinamide adenine dinucleotide (NAD+) levels alleviates the progression of age-related diseases and promotes healthy life expectancy. Several studies have demonstrated that NAD+ levels can be efficiently replenished via intake of nicotinamide mononucleotide (NMN), and the safety of oral ingestion of NMN has been confirmed in recent clinical trials on healthy Japanese men. However, the efficacy and safety of intravenous NMN administration in humans remains unclear. Therefore, we verified the safety of NMN via venous intake in 10 healthy volunteers. Intravenous administration of NMN did not affect electrocardiograms, pulse, and blood pressure, nor did it affect metabolic markers in the liver, heart, pancreas, and kidneys. Furthermore, NMN administration not only significantly increased blood NAD+ levels without damaging blood cells, but also significantly improved sleep quality. Therefore, our findings indicate that intravenous NMN administration in humans is safe and beneficial for the prevention of aging-related diseases.