RISK FACTORS ASSOCIATED WITH READMISSION FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION AMONG CHILDREN

RISK FACTORS ASSOCIATED WITH READMISSION FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION AMONG CHILDREN | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 11 June 2025 V1 Latest version Share on RISK FACTORS ASSOCIATED WITH READMISSION FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION AMONG CHILDREN Authors : Maria E. Lopez Garcia [email protected] , Kristin Lieb , Jin Zhezhen , Monica Bhatia , Diane George , James Garvin , Larisa Broglie 0000-0002-1674-048X , and Prakash Satwani Authors Info & Affiliations https://doi.org/10.22541/au.174962427.73835925/v1 Published Transplantation and Cellular Therapy Version of record Peer review timeline 229 views 146 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Introduction/Background: Patients are readmitted for various complications during the first year post allogeneic hematopoietic cell transplantation (alloHCT). Readmissions are associated with higher utilization of health care resources and cost, negatively impacting quality of life. While several studies have described risk factors for readmission in adult patients, limited data are available for the pediatric AlloHCT recipients. Understanding and addressing the modifiable risk factors that drive readmissions after alloHCT can potentially improve transplant outcomes and decrease healthcare utilization. Objectives: This study aimed to identify modifiable risk factors associated with hospital readmission among pediatric alloHCT recipients. Design/Methods: A single-center retrospective cohort study was conducted, encompassing children discharged from the hospital after their first alloHCT between June 1, 2008, and January 2021. The primary endpoint of the analysis was hospital readmission after initial hospitalization for alloHCT. We studied three different aspects of readmissions: 1) whether readmission occurred, 2) the quantity of post-alloHCT readmissions per patient, 3) timing of readmission (early <30 days vs. late ≥30 days from first hospital discharge). Logistic regression was employed to evaluate pre-transplant characteristics, sociodemographic factors, and transplant complications associated with readmission. Results: Of 216 patients who were discharged after alloHCT, 186 were readmitted within a year, with a median number of readmissions at 2 (ranging from 0 to 17). On multivariable analysis, significant risk factors associated with readmission were non-English speaking families, occurrence of acute graft-versus-host disease (aGVHD) prior to discharge, CD4 count 20mg/dL at the time of discharge, and presence of an external central line at discharge. The impact of an institutional practice change in 2019 to remove external central lines prior to discharge was studied to determine if readmission rates changed; readmission rates were higher in 2008-2018, before the change, as compared to after the in change 2019-2021 (90% vs. 71%, respectively). The primary etiology of readmission in the earlier time period as compared to the later was identified to be due to bacteremia (25% vs. 3%, respectively). Conclusions: Most children are readmitted following discharge after alloHCT. Modifiable risk factors should be targeted in future research efforts to decrease re-hospitalization. Prospective multicenter studies are needed which could potentially improve the outcomes and quality of life of children. Supplementary Material File (riskfactorsassociatedwithreadmissionfollowingallogeneichematopoieticcelltransplantationamongchildren.docx) Download 987.69 KB Information & Authors Information Version history V1 Version 1 11 June 2025 Peer review timeline Published Transplantation and Cellular Therapy Version of Record 1 Feb 2024 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords bmt outcomes research stem cell transplantation support care Authors Affiliations Maria E. Lopez Garcia [email protected] NewYork-Presbyterian Hospital View all articles by this author Kristin Lieb Johns Hopkins All Children's Hospital View all articles by this author Jin Zhezhen Columbia University Herbert Irving Comprehensive Cancer Center View all articles by this author Monica Bhatia NewYork-Presbyterian Hospital View all articles by this author Diane George NewYork-Presbyterian Hospital View all articles by this author James Garvin NewYork-Presbyterian Hospital View all articles by this author Larisa Broglie 0000-0002-1674-048X Medical College of Wisconsin Division of Hematology and Oncology View all articles by this author Prakash Satwani NewYork-Presbyterian Hospital View all articles by this author Metrics & Citations Metrics Article Usage 229 views 146 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Maria E. Lopez Garcia, Kristin Lieb, Jin Zhezhen, et al. RISK FACTORS ASSOCIATED WITH READMISSION FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION AMONG CHILDREN. Authorea . 11 June 2025. DOI: https://doi.org/10.22541/au.174962427.73835925/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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