ASSOCIATION BETWEEN VITAMIN D LEVEL AND SERUM LIPID PARAMETERS AMONG INDIAN ADULTS WORKING IN IT SECTOR: A RETROSPECTIVE OBSERVATIONAL STUDY

ABSTRACT Background & objectives Association between serum vitamin D levels and lipid levels has been focus of research in recent times. The relationship of 25(OH)D and Atherogenic Index of Plasma is not well established among Indian population. We investigated the prevalence of vitamin D deficiency, its relation with serum lipids and AIP among IT employees. Methods A retrospective observational study was conducted among employees of multiple IT firms in Bangalore, India. Participants were selected by convenient sampling from annual comprehensive health screening at work place. Serum lipid levels were assessed auto-analyser (ADVIA1650; Siemens, NY, USA). Serum 25(OH)D was assessed by Chemiluminescent microparticle immunoassay. AIP was calculated as log [Triglycerides/HDL-Cholesterol]. Results Among 533 subjects included final analysis, mean of age was 33.18±6.6 with Male: female ratio of 1.8:1. Vitamin D deficiency and AIP > 0.15 was observed in 405 (75.98%) and 450 (84.43%) participants respectively. Median HDL-cholesterol was significantly lower (42 Vs 45.5, P value 0.004) and LDL cholesterol was significantly higher (90 Vs 52, P value <0.001) among people with vitamin-D deficiency. LDL (Spearman Rho=-0.18, P <0.001) had weak negative correlation, Total cholesterol (Spearman Rho=-0.1, P Value <0.01) and VLDL (Spearman Rho=-0.18, P Value <0.001) had weak positive correlation with 25(OH)D. No statistically significant association was observed between AIP and vitamin-D. Conclusions More than two thirds of IT employees were deficient in vitamin D. Vitamin D deficiency was associated with significantly higher LDL, lower HDL and VLDL levels. No statistically significant association was observed between vitamin D and AIP.