Superior long-term patency of no-touch vein graft compared to conventional vein grafts in over 1500 consecutive patients

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Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search Superior long-term patency of no-touch vein graft compared to conventional vein grafts in over 1500 consecutive patients View ORCID Profile Gabriele Ferrari , Richard Loayza , Ava Azari , Håkan Geijer , View ORCID Profile Yang Cao , Roland Carlsson , View ORCID Profile Leif Bojö , View ORCID Profile Ninos Samano , View ORCID Profile Domingos Souza doi: https://doi.org/10.1101/2024.02.19.24303064 Gabriele Ferrari 1 University Health Care Research Centre, Faculty of Medicine and Health, Örebro University , Örebro, Sweden 2 Department of Cardiology and Cardiothoracic Surgery, Blekinge Hospital , Karlskrona, Sweden MD Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Gabriele Ferrari For correspondence: gabriele.ferrari{at}regionblekinge.se Richard Loayza 1 University Health Care Research Centre, Faculty of Medicine and Health, Örebro University , Örebro, Sweden MD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ava Azari 1 University Health Care Research Centre, Faculty of Medicine and Health, Örebro University , Örebro, Sweden MD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Håkan Geijer 3 Department of Radiology, Faculty of Medicine and Health, Örebro University , Örebro, Sweden MD, PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yang Cao 4 Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University , Örebro, Sweden PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Yang Cao Roland Carlsson 5 Svensk PCI AB, Regional Hospital of Karlstad , Karlstad, Sweden MD, PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Leif Bojö 6 Clinical Physiology Division, Regional Hospital of Karlstad , Karlstad, Sweden MD, PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Leif Bojö Ninos Samano 1 University Health Care Research Centre, Faculty of Medicine and Health, Örebro University , Örebro, Sweden MD, PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Ninos Samano Domingos Souza 1 University Health Care Research Centre, Faculty of Medicine and Health, Örebro University , Örebro, Sweden MD, PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Domingos Souza Abstract Full Text Info/History Metrics Data/Code Preview PDF ABSTRACT Objectives To evaluate the long-term angiographic patency of saphenous vein grafts (SVG) harvested using the no-touch technique compared to the conventional technique. Methods This was a single-center, retrospective, cohort study. The inclusion criteria were individuals who underwent a CABG (coronary artery bypass grafting) between January 1995 and July 2020, and who successively needed a clinically-driven angiography. The primary endpoint was long-term patency. The secondary endpoints were differences in patency based on sub-group analysis (single vs. sequential graft, divided by target vessel). Results The study included 1520 individuals (618 no-touch, 825 conventional and 77 arterial grafts). The mean clinical follow-up time was 8.4 years ± 5.5 years. The patency per patient was 70.7% in the no-touch grafts vs. 46.7% in the conventional grafts (p < 0.001, OR = 2.8). The graft patency was 75.9% in the no-touch grafts vs. 62.8% in the conventional grafts (p < 0.001, OR= 1.8). Conclusions The no-touch vein grafts were associated with statistically significantly higher patency at long-term compared to the conventional grafts. Clinical Trial Registration NCT04656366, 7 December 2020 Clinical Perspective - What is new? ➣ The largest follow-up of the patency of no-touch vein grafts in the international literature. ➣ Patients with a no-touch vein graft had significantly better patency (p < 0.001) at mean follow-up of more than 8 years. - What are the clinical implications? ➣ Consequent reduction in cardiovascular events after no-touch vein graft. ➣ Benefits at individual level due to fewer episodes of re-angina and myocardial infarction, and fewer coronary interventions. ➣ Benefits at community level due to fewer re-hospitalizations and a reduction in healthcare costs. Introduction Ischemic heart disease is the leading cause of death worldwide, accounting for almost 8.9 million deaths in 2019 1 . The main treatment options are percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and, in some cases, both. The choice of treatment depends on the clinical presentation, grade of disease, type of lesion, and patient comorbidities. Guidelines 2 – 4 recommend CABG in cases of multivessel disease or left main stem, and/or diabetes mellitus, to improve survival and reduce the risk of major adverse cardiac events (MACE) 5 – 9 , which are defined as death, myocardial infarction (MI), in-stent restenosis, and/or repeated target vessel revascularization (TVR). The grafts used, especially vein grafts, are subject to remodelling and progressive intimal hyperplasia and atherosclerosis, which may lead to graft stenosis or occlusion and thereby limit the graft patency 7 . These events occur more frequently and rapidly in saphenous vein grafts (SVGs) compared to left internal thoracic artery (LITA) or other arterial grafts 8 , 9 . Graft patency after CABG is a major determinant of clinical prognosis and long-term survival 7 . The no-touch (NT) technique 10 differs from the conventional technique in that it is associated with less endothelium damage during the harvesting procedure 11 , 12 and leads to reduced neo-intimal hyperplasia and subsequent atherosclerosis in the long term 13 , 14 . The aim of this study was to evaluate the long-term angiographic patency of saphenous vein grafts (SVG) harvested using the NT technique compared to the conventional technique. This is a single-center, retrospective, cohort study. The study complied with the STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) statement and the STROBE checklist was used 15 . Material and Methods Data collection This single-center study included all individuals treated with a CABG between January 1, 1995 and June 30, 2020 at our Cardiothoracic Department and who successively needed a clinically driven-angiography. The study was a single-center study involving a center with long experience with the NT technique having used it for harvesting the saphenous vein since 1990. The study was performed in accordance with the Declaration of Helsinki. The Regional Ethical Review Board approved the study (Dnr 2020/04168). The standard operation in our center has been to anastomise the LITA to the LAD (left anterior descending) and vein grafts to the other target vessels; in some cases, total arterial revascularization (A) occurred. The SVG was harvested either with the NT or with the C technique, as previously described 16 . The type of technique used was chosen by the surgeon at the time of operation based on individual assessment and, therefore, without randomization. The angiographies were performed in two cardiology departments and were clinically driven, being due to either angina or myocardial infarction. No planned angiographic follow-up was performed. No exclusion criterion was defined. The grade of stenosis and its significance was defined according to the 2021 American Heart Association for coronary artery revascularization 17 . A limit of 70% was set for the non-left main stenosis and 50% for the left main stenosis or for graft stenosis; in case of doubt, the severity of the lesion was confirmed using the FFR (fractional flow reserve) or the iFR (instantaneous wave-free ratio). The operative data (CABG) and the procedural data were collected with the help of an intervention-related quality register (the Swedish cardiological and cardiosurgical intervention register Swedeheart) 18 . The operative data regarding the type of vein graft, the number of anastomoses, and the target vessel for the peripheral anastomosis were extracted and double checked by reviewing records in the clinical software of the two hospitals involved. Statistical methods The primary endpoint was defined as long-term patency. Secondary outcomes were the differences between single grafts and sequential grafts, and the different territories fed by the stenosed vein graft based on sub-group analyses. Descriptive statistics were calculated as means ± standard deviations (SD) for normally distributed variables, as median with interquartile range (IQR) for non-normally distributed variables, and as count with percentage for categorical variables. The Chi-squared test (or Fisher’s exact test for an expected count lower than 5) was used to compare categorical proportions between the two groups (NT and C). The unpaired t-test was performed to compare continuous variables and the Mann-Whitney U-test was used in cases of non-normally distributed data. Statistical analyses were performed using SPSS version 27.0 (IBM, Armonk, NY, USA). Results Between January 2006 and July 2020, 1571 individuals who had previously been treated with CABG needed an angiography ( Figure 1 ). Fifty-one were lost at follow-up due to the inability to access the surgical reports (i.e., microfilm not available, journal lost, data protection). Download figure Open in new tab Figure 1: STROBE flowchart of the individuals included in the study A: arterial graft alone; C: conventional graft; CABG: coronary artery bypass grafting; NT: no-touch graft; PCI: percutaneous coronary intervention; SVG: saphenous vein graft. The study included 1520 consecutive patients (618 NT, 825 C, 77 A) who needed a postoperative angiography (see Figure 1 and Table 1 ) with a mean follow-up time of 8.4 ± 5.5 years and up to 24.7 years. The study analysed 2564 venous grafts (908 NT, 1656 C), Table 2 . View this table: View inline View popup Download powerpoint Table 1: Graft characteristics of the patients in the total population View this table: View inline View popup Download powerpoint Table 2: Vein graft characteristics of the two groups In 29 cases, the angiography was only diagnostic and no new stenosis was detected. In 614 cases, stenoses were present in at least one vein graft. One hundred and thirty individuals presented with a stenosis in an arterial graft, and in 747 cases the new stenosis affected only the native vessels. Demographic, operative, and procedural characteristics A total of 1443 individuals received an SVG at surgery (618 NT, 825 C). The demographic, operative and angiographic characteristics of this group are summarized in Table 3 . The demographic characteristics of the two groups were similar and patients had a comparable age at the time of CABG (63.2 ± 8.6 years NT, 63.1 ± 21.1 years C; p = 0.893; Table 3 ); most of the patients were male (78.5%). The risk factor distribution showed a significantly higher rate of hypertension (89% NT vs. 83.3% C) and hypercholesterolemia (91.7% NT vs. 84% C) in the NT group (p < 0.001). Fewer patients with an NT SVG received a post-operative DAPT (dual anti platelet therapy), 35.4% NT vs. 44% C (p = 0.001). View this table: View inline View popup Download powerpoint Table 3: Demographic characteristics of the individuals who received a saphenous vein graft The operative characteristics regarding number of peripheral anastomoses were similar in the two groups ( Table 4 ). No differences regarding the indication for the new angiography were presented (p = 0.916), Table 4 . View this table: View inline View popup Download powerpoint Table 4: Operative and procedural characteristics of the individuals who received a saphenous vein graft The mean follow-up time was 5.5 ± 4.4 years for the individuals with an NT SVG and 10.7 ± 5.1 years for the individuals with a C SVG. Clinical follow-up Primary endpoint The total patency rate per patient was 70.7% (437/618) in the NT group and 46.7% (385/825) in the C group (p < 0.001), with an OR (odds ratio) of 2.8, Table 5 . View this table: View inline View popup Download powerpoint Table 5: Patency rate per patient of no-touch and conventional vein grafts, and patency of arterial grafts divided by type of vein graft The patency rate per graft was 75.9% (609/908) in the NT group and 63.5% (1051/1656) in the C group (p < 0.001), with an OR of 1.8, Table 6 . View this table: View inline View popup Download powerpoint Table 6: Patency in no-touch and conventional vein grafts divided by type of graft Secondary endpoint Single grafts vs. sequential grafts In the analysis of the different types of graft received (single or sequential), there was a statistically significant higher patency in the NT group both for single grafts (75.6% NT vs. 62.8% C, p < 0.001) and for sequential grafts (76.0% NT vs. 65.3% C, p < 0.001), Table 6 . Territories fed by the stenosed vein graft The subgroup analysis, divided by distal anastomosis, revealed statistically significantly better results for the NT grafts for each of the different distribution territories, Table 7 . The patency of the NT SVGs was over 80% if the target vessel was a coronary of the left system, and around 70% if the target vessel was the right coronary artery (RCA). In contrast, the patency of the C SVGs was as low as 57% if the target vessel was the RCA, and never reached 80% in the left system. The differences between the NT and the C in the four different territories of distribution were significant even when analysing the single and the sequential grafts separately; however, the exceptions were the single grafts to the marginal artery (MA), the sequential ones to RCA, and both types to the left anterior descending (LAD) due to the limited number of included individuals, Table 7 . View this table: View inline View popup Download powerpoint Table 7: Patency of no-touch and conventional vein grafts divided by territory of distribution and sub-divided by graft type (single or sequential) Patency of arterial grafts The long-term patency of the total arterial grafts was 86.3% and of the LITA grafts 96.2%. The patency rates for arterial grafts were similar regardless of whether the patients received an SVG or not, Table 5 . Discussion This study presents the results from the largest long-term follow-up investigation of the qpatency of NT SVGs. The main finding of this study was higher graft patency at follow-up of the NT grafts (75.9%), compared to the C grafts (63.5%); p < 0.001. The superiority of the NT SVG was shown even when the different types of grafts (single vs. sequential) and the different types of territory of distribution were analysed. It has to be mentioned that NT grafts have shorter follow-up compared to the C grafts; however, this is due to higher rates of restenosis in the native vessels and not in the SVGs themselves. It is known that C SVGs have high risks of thrombosis, intimal hyperplasia, and early atherosclerosis, which all lead to graft occlusion rates of up to 50-60% after 10 years, according to most clinical records 19 – 21 . Our study showed similar results for the C grafts with a patency per patient of only 46.7% at a mean follow-up of 8.4 years. The NT grafts, on the other hand, present a patency per patient of more than 70% at follow-up (OR of 2.8) and of almost 76% per graft. Several studies 11 , 13 , 14 , 16 , 22 – 25 have shown the superiority of NT SVGs compared to C SVGs on follow-up at a mean time up to 16 years 14 . Previous studies have, however, had either a limited follow-up time of maximum 1 year 22 , 23 , 25 or included a limited number of patients (fewer than 300) 11 , 13 , 14 , 16 , 23 , 24 . The present study is the first to include both a large cohort, more than 1500 individuals, and a mean follow-up time of more than 5 years and up to almost 25 years. The higher long-term patency of NT SVGs may play an important role in reduced long-term MACE and re-hospitalization rates. In our previous study 26 we noted a very limited number of patients with NT SVGs being treated with PCI compared to C (63 NT vs. 246 C). We also noted that almost 70% of patients who needed a coronary angiography after the CABG operation did not receive a PCI on their vein graft. The present study gives an explanation for these observations; more than half (57.6%) of the patients with an NT SVG who needed a postoperative angiography did not have a SVG stenosis, but presented with a new stenosis in the native vessels. This occurred in only 39.6% of patients with a C SVG. Another interesting data is the higher percentage of sequential grafts in the NT group (49.3% vs. 24.7%). This is possible thanks to the qualities of the NT grafts that are much less prone to kinking when performing multiple anastomoses 12 , comparing the C technique. As previously mentioned, NT grafts have a shorter time to follow-up compared to C grafts, with only 23 cases (vs. 124) needing an angiography more than 15 years after the operation. This shorter follow-up time for NT grafts is due to a lower patency rate of native vessels in these individuals. A possible explanation is the statistically significant difference (35.4% vs 44.0%, p = 0.001) in the use of DAPT, with NT grafts receiving postoperative DAPT in fewer cases compared to C grafts. The benefits of DAPT after an acute coronary syndrome, in terms of reduced risk of restenosis and higher short- and long-term patency rates, are well known and supported by the international guidelines 27 . Another possible explanation is that in the 1990’s, the C graft was used in most cases so these patients automatically have a longer follow-up time than the NT grafts. The main limitation of this study is that it is non-randomized and the choice of graft type was dependent on the surgeon’s choice. Another limitation is the different follow-up times in the two groups. Conclusions The results regarding the NT SVGs are encouraging, with statistically significantly higher patency at long-term follow-up compared to a C SVG, and with an almost 50% reduction in cases of vein graft stenosis long-term. The results suggest an important reduction of cardiovascular events if the patients receive comparable medical treatment post-surgery and if the management of the risk factors follows the guidelines. Randomized studies are needed to evaluate the performance and benefits of NT SVGs at both individual (better patency and fewer coronary interventions) and community (fewer re-hospitalizations) levels. Data Availability https://classic.clinicaltrials.gov/ct2/show/NCT04656366 Sourcing of Fundings This work was supported by Region Örebro County through the regional research board (grant OLL-OLL-935188, 18 January 2020). Disclosures None. Supplementary Files Supplementary Table S1 Supplementary Table S2 Supplementary Table S3 Author contribution statement Gabriele Ferrari, Håkan Geijer, Ninos Samano, Domingos Souza, Roland Carlsson and Leif Bojö devised the original concept of this study. Gabriele Ferrari, Håkan Geijer, Ninos Samano, Domingos Souza, Roland Carlsson and Leif Bojö designed the study. Gabriele Ferrari, Richard Loayza and Ava Azari collected the patient data. Gabriele Ferrari, Richard Loayza and Ava Azari performed the statistical analysis. Yang Cao provided support for statistical analysis and result explanation. Gabriele Ferrari, and Yang Cao wrote the first draft of the manuscript. All authors reviewed the manuscript, contributed significantly to its critical review, and approved the final version. Acknowledgements We thank research assistant Ulf Graf for help with the database settings. Non-standard abbreviations and non-standard acronyms A arterial graft BMS bare metal stent C conventional CABG coronary artery bypass grafting DA diagonal artery DAPT double antiplatelet therapy DES drug-eluting stent EF ejection fraction FFR fractional flow reserve iFR instantaneous wave-free ratio IQR interquartile range LAD left anterior descending artery LITA left internal thoracic artery MA marginal artery MACE major adverse cardiac events MI myocardial infarction NT no-touch OR odds ratio PCI percutaneous coronary intervention RCA right coronary artery RITA right internal thoracic artery SD standard deviation SVG saphenous vein graft TIMI thrombolysis in myocardial infarction TVR target vessel revascularization References 1. ↵ WHO . 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Share Superior long-term patency of no-touch vein graft compared to conventional vein grafts in over 1500 consecutive patients Gabriele Ferrari , Richard Loayza , Ava Azari , Håkan Geijer , Yang Cao , Roland Carlsson , Leif Bojö , Ninos Samano , Domingos Souza medRxiv 2024.02.19.24303064; doi: https://doi.org/10.1101/2024.02.19.24303064 Share This Article: Copy Citation Tools Superior long-term patency of no-touch vein graft compared to conventional vein grafts in over 1500 consecutive patients Gabriele Ferrari , Richard Loayza , Ava Azari , Håkan Geijer , Yang Cao , Roland Carlsson , Leif Bojö , Ninos Samano , Domingos Souza medRxiv 2024.02.19.24303064; doi: https://doi.org/10.1101/2024.02.19.24303064 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Cardiovascular Medicine Subject Areas All Articles Addiction Medicine (573) Allergy and Immunology (865) Anesthesia (302) Cardiovascular Medicine (4453) Dentistry and Oral Medicine (444) Dermatology (383) Emergency Medicine (609) Endocrinology (including Diabetes Mellitus and Metabolic Disease) (1515) Epidemiology (15242) Forensic Medicine (30) Gastroenterology (1131) Genetic and Genomic Medicine (6615) Geriatric Medicine (669) Health Economics (1001) Health Informatics (4552) Health Policy (1372) Health Systems and Quality Improvement (1614) Hematology (543) HIV/AIDS (1270) Infectious Diseases (except HIV/AIDS) (15929) Intensive Care and Critical Care Medicine (1106) Medical Education (624) Medical Ethics (147) Nephrology (670) Neurology (6625) Nursing (346) Nutrition (999) Obstetrics and Gynecology (1148) Occupational and Environmental Health (957) Oncology (3344) Ophthalmology (979) Orthopedics (369) Otolaryngology (421) Pain Medicine (436) Palliative Medicine (130) Pathology (665) Pediatrics (1696) Pharmacology and Therapeutics (693) Primary Care Research (714) Psychiatry and Clinical Psychology (5461) Public and Global Health (9252) Radiology and Imaging (2207) Rehabilitation Medicine and Physical Therapy (1371) Respiratory Medicine (1197) Rheumatology (597) Sexual and Reproductive Health (715) Sports Medicine (530) Surgery (714) Toxicology (99) Transplantation (289) Urology (265) (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a02f9beb9ef5df94',t:'MTc3OTk5NTk0Ng=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();