The causal relationship between gastroesophageal reflux disease and chronic kidney disease：A Two-Sample Mendelian Randomization Study

Background: The causal relationship between gastroesophageal reflux disease (GRED) and chronic kidney disease (CKD) is unclear. In this paper, Mendelian randomization method was used to determine the causal effect of GRED disease and CKD, and to identify the risk factors of chronic kidney disease. Method: Two-sample Mendelian randomization (MR) was used to explore the causal relationship between GRED and CKD. We used a dataset from a recent large-scale genome-wide association study (GWAS). Although we use inverse variance weighting (IVW), MR-Egger and weighted median methods for analysis. Result: There were significant differences in IVW results, suggesting that GRED patients may be causally associated with CKD disease, and GRED patients may have an increased risk of CKD. Conclusion: GRED may be one of the risk factors for CKD.