HPGDS as a biomarker for prognosis and immunotherapy in pancreatic cancer

HPGDS as a biomarker for prognosis and immunotherapy in pancreatic cancer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article HPGDS as a biomarker for prognosis and immunotherapy in pancreatic cancer Hao Ye, Zhengyang Zhou, Chenjun Xie, Ge Gao, Qingwen Wang, Xiaoyun Wang, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6637568/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Pancreatic ductal adenocarcinoma (PDAC), a highly aggressive malignancy with a poor prognosis, is partly attributed to its immunosuppressive microenvironment. Hematopoietic prostaglandin D synthase (HPGDS), a key enzyme in prostaglandin D2 biosynthesis, plays a significant role in lipid metabolism and inflammatory signalling. Here, we comprehensively investigated the expression profile, biological significance, and immunotherapeutic potential of HPGDS in PDAC via bioinformatics analyses and experimental approaches. Our findings revealed that HPGDS is highly expressed in pancreatic cancer tissues and cell lines and is closely associated with low tumor differentiation and immune evasion. Notably, HPGDS knockdown significantly inhibited pancreatic cancer cell proliferation. This study identifies HPGDS as a potential biomarker for prognosis and therapeutic efficacy assessment in patients with PDAC and suggests that it could be a promising target for developing novel immunotherapies. HPGDS Pancreatic cancer Immune microenvironment Prognosis Biomarker Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6637568","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":458149082,"identity":"1c97934a-7cdb-4120-ade9-96834657f793","order_by":0,"name":"Hao Ye","email":"","orcid":"","institution":"Affiliated Hospital of Jiangnan University","correspondingAuthor":false,"prefix":"","firstName":"Hao","middleName":"","lastName":"Ye","suffix":""},{"id":458149083,"identity":"57f43843-46e1-4ccb-afda-6cb784f2a0fb","order_by":1,"name":"Zhengyang Zhou","email":"","orcid":"","institution":"Jiangnan 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Hematopoietic prostaglandin D synthase (HPGDS), a key enzyme in prostaglandin D2 biosynthesis, plays a significant role in lipid metabolism and inflammatory signalling. Here, we comprehensively investigated the expression profile, biological significance, and immunotherapeutic potential of HPGDS in PDAC via bioinformatics analyses and experimental approaches. Our findings revealed that HPGDS is highly expressed in pancreatic cancer tissues and cell lines and is closely associated with low tumor differentiation and immune evasion. Notably, HPGDS knockdown significantly inhibited pancreatic cancer cell proliferation. 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