A comparison of danazol and placebo in the treatment of adult idiopathic gynaecomastia: results of a prospective study in 55 patients.
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Danazol 200 mg twice daily for 3 months significantly improved adult idiopathic gynaecomastia symptoms and size compared to placebo, though it caused weight gain.
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Abstract
In an attempt to define the efficacy of danazol in the treatment of idiopathic gynaecomastia, 55 patients were enrolled into a randomised double-blind comparison of danazol 200 mg twice daily for 3 months against placebo. The results of 52 patients were evaluated, three patients being excluded because of protocol violations. Danazol improved breast tenderness to a significantly greater degree than did placebo (P = 0.022, danazol vs placebo) and was associated with statistically significant improvement in the degree of gynaecomastia and in its measured size (P less than 0.05). The intended management of patients who had received danazol was less likely to be surgery compared to the placebo group when assessed at the end of treatment (27% vs 50%). Minor side effects were common in both groups, but significant weight gain was noted in the danazol group alone. If there is no urgent need for rapid resolution of gynaecomastia, danazol 200 mg twice daily can provide effective control of symptoms and may obviate the need for surgery.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- Danazol therapy in gynaecomastia; recent experience and indications for therapy. 1979
- [Steroid treatment of adolescent gynecomastia with danazol (author's transl)]. 1981
- [Excessive gynecomastia in boys. Effective medical treatment using danazol (Winobanin)]. 1984
Cited by (2)
- Danazol 2022
- How should gynaecomastia be managed? 2003
References (5)
- Danazol therapy in gynaecomastia; recent experience and indications for therapy. via openalex
- [Excessive gynecomastia in boys. Effective medical treatment using danazol (Winobanin)]. via openalex
- [Steroid treatment of adolescent gynecomastia with danazol (author's transl)]. via openalex
- doi:10.1001/jama.1961.03040440001001 via openalex
- W10016006 via openalex
Cited by (2)
- Danazol 2022
- How should gynaecomastia be managed? 2003
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- openalex
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