Functional Connectivity and Disability in Multiple Sclerosis: a Cross-sectional Study

Multiple Sclerosis (MS) is characterized by an inflammatory demyelinating disease that affects the Central Nervous System (CNS). This disease results in lesions in the white and gray matter of the brain network architecture and can play an important role in the clinical symptoms. The objective of this study was to verify the connectivity of brain networks through RSfMRI in two different groups of MS when compared to mild (n = 26) and moderate (n = 25) EDSS. The results showed statistically significant differences -*between the groups. The moderate EDSS showed increased rsFC in the Right Posterior Cingulate Cortex, Left and Right Precuneus, Left Superior Temporal Gyrus, and Left Middle Cingulate Cortex compared to mild EDSS. We suggest studies that examine the combination of structural and functional changes in disability in MS