Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease

Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease Xiuqin An, Jinchun Liu, Xiaojuan Zheng, Zhangfeng Dou, Yue Li, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.18035/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background/Aims: It was suggested that serum HGF,PCIII and PLT play important roles in nonalcoholic fatty liver disease (NAFLD). Thus, we aimed to evaluate their clinical utility in the diagnosis of patients with suspected NAFLD. Methods:300 Patients with NAFLD were compared to 102 matched controls.All were subjected to history taking, anthropometric measurements, and abdominal ultrasonography, as well as laboratory assessments of liver functions, fasting lipid profile, GLU, serum PLT, HGF and PCIII. Results:The levels of HGF,PCIII and PLT were higher in NAFLD cases than controls ,and with progressive increases as the severity of fatty liver increased（P<0.05）.HGF,PCIII and PLT were correlated with various clinical parameters and severity of NAFLD（P<0.05）.The optimal cut-off values for HGF in diagnosis of mild, moderate and severe fatty liver were 14.1pg/ml(AUROC 0.753,P＝0.004), 15.4pg/ml(AUROC 0.836, P < 0.001), 17.7pg/ml(AUROC 0.903, P < 0.001). PCIII had no value in differentiate mild from moderate fatty liver ,but its ability to diagnose severe fatty liver was significant. A cut-off value for PCIII to diagnose severe fatty liver was 7.9ng/L(AUROC 0.773).The optimal cut-off values for PLT in the diagnosis of mild, moderate and severe fatty liver were 194×10^9/L(AUROC 0.732), 195×10^9/L(AUROC 0.765), 200×10^9/L(AUROC 0.925), respectively with P < 0.001. When three indicators were tested together,the AUROC(95%CI)curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873)(P<0.001) . Conclusion:.Combined detection of serum HGF, PCIII and PLT may be an effective non-invasive method for diagnosing NAFLD. Gastroenterology & Hepatology Nonalcoholic fatty liver disease (NAFLD) Hepatocyte growth factor(HGF) Serum type iii procollagen (PCIII) platelet(PLT) Noninvasive diagnostic Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome, which is characterized by excessive accumulation of fat content in hepatocytes. The spectrum of NAFLD disease includes nonalcoholic simple fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), liver fibrosis, liver cirrhosis and liver cancer. Numerous risk factors are associated with the development and progression of NAFLD, including obesity, visceral obesity, insulin resistance and features of the metabolic syndrom[ 1 ].The worldwide prevalence of NAFLD is currently estimated to be in the range of 6% to 37%, with a reported pooled overall global prevalence of 25%[ 2 ],As the global epidemic of NAFLD, the clinical and economic burden of NAFLD will become enormous.Although Liver biopsy is the gold standard for the diagnosis, grading, and staging in patients with NAFLD, but it has its own limitations, such as the risk of sampling error, high rates of inter- and intraobserver differences, risk of complications, and the high cost and so on[ 3 ]. Thus, it is important to develop efficient noninvasive diagnostic methods for NAFLD and numerous noninvasive diagnostic method have been developed worldwide. Hepatocyte growth factor (HGF) is a multifunctional pleiotropic cytokine,is not only an anti-apoptotic and anti-fibrotic factor in the liver, but also a adipokine[ 4 ].HGF is initially produced as a biologically inactive, single-chain precursor form,After proteolytic cleavage,it converts to the active form to Participate in various physiological activities[ 5 ].Tojima[ 6 ]et al. showed that HGF overexpression could alleviate the pathological changes of hepatitis and liver fibrosis in a murine model of NASH induced by methionine-choline deficiency (MCD) diet due to its antioxidant, antiapoptotic and plasminolytic effects. Kroy DC[ 7 ]et al. also demonstrated the protective role of HGF in the development of NAFLD by by knocking out of HGF receptor cMet in mouse hepatocytes.In addition, previous studies found that HGF was significantly high in patients with NASH and it correlated with Various parameters of metabolic syndrome[ 4 ]. The development of hepatic fibrosis is an important event in the progression of liver disease. Serum type III procollagen peptide (PIIIP), a degradation product of the type III collagen precursor and has been shown to be a negative prognostic factor in chronic hepatitis[ 8 ].Serum PIIINP levels increased significantly along with the increasing severity of liver inflammation[ 9 ].Procollagen-III peptide also could identify adipose tissue(AT)-associated inflammation in type 2 diabetes with or without nonalcoholic liver disease,Higher PIIINP levels correlated with greater BMI and visceral AT area and were associated with systemic signatures of AT-associated inflammation[ 10 ]. The platelet is the primary cell for hemostasis and tissue repair.Many studies have shown that PLT plays a role in the inflammatory response after hepatic damage[ 11 , 12 ].Recent clinical and experimental evidences also support that platelets play several roles in the progression of malignancies and inversely, cancer can also influence platelet count and activity[ 13 ].Sangbin Han et al. ‘s findings suggested that platelets play an important role in HCC cells metastasis and preoperative platelet count was independently correlated with post-transplant HCC recurrence[ 14 ]. Thus, the current study attempted to evaluate the clinical utility of serum HGF,PIIIP and PLT levels in the diagnosis of suspected NAFLD. Methods Patients and methods A total of 300 patients diagnosed with NAFLD and 102 sex- and age-matched healthy volunteers without NAFLD were included in this study from Novemble 2016 to Novemble 2018. All patients were diagnosed with NAFLD based on ultrasound imaging made under fasting conditions.The grade of fatty liver was categorized as follows: (1) mild steatosis: increased echogenicity of the liver as compared with the renal cortex or spleen; (2) moderate steatosis: obscured hepatic and portal vein walls, and (3) severe steatosis: impaired visibility of the diaphragm[ 15 ].Subjects with a history of excessive alcohol consumption (weekly consumption of ≥140 g for men or ≥70 g for women), other liver diseases such as chronic hepatitis, or use of drugs known to be associated with the development of fatty liver, body weight reduction or thyroid disorders were excluded[ 16 ]. Physical examination of each patient included body weight, height,calculation of body mass index (BMI) .Blood samples were collected after 12 hours of fasting,the serum was obtained after centrifugation at 3000 RPM for 15min and Stored in a - 80℃ low temperature refrigerator.Analyses included liver function tests(AST, ALT, CHE, TBIL,DBIL,IBIL,TBA, TP,ALB and ALP), lipid profile（TC,TG,HDL,LDL）, GLU,HGF,PCIII and PLT. The HGF, PIIIP were assayed using ELISA kit purchased from WuHan Elliot biotechnology co. LTD.Other biochemical indicators were detected by automatic biochemical instrument purchased from Beijing anxin haichuang technology co,LTD. Statistical analysis A statistical analysis was performed using Medcalc 19.0. The measurement data conforming to the normal distribution were expressed by mean ± standard deviation (SD).T- test was used for comparison between two groups.Univariate anova was used for multigroup comparison and Lsd-t test was used for further pairwise comparison. The measurement data of non-normal distribution were expressed by [M (p25-p75)], mann-whitneyu test was used for comparison between two groups, and kruskal-wallis H test was used for comparison between multiple groups.X 2 test was used to compare counting data between groups. The area under the ROC curve (AUC) was calculated, and its diagnostic validity was tested by Z test, and the optimal cut-off value (YI=Se+ sp-1) was determined by Jordan index. P <0.001 was considered statistically significant.Spearman rank correlation analysis was used to analyze the correlation between HGF, PCIII ,PLT and clinical parameters and severity of NAFLD ( P <0.05). Results Table 1 showed the laboratory and clinical characteristics of NAFLD patients and the control group.Levels of BMI,GLU,ALT,AST,TG,ALP,GGT,GPRI(GGT/PLT), DBIL,IBIL,TBA,TP,HGF,PCIII and PLT were significantly higher in the NAFLD patients compared with the control group,ALB was significantly lower in the NAFLD patients compared with the control group,(all P <0.05).In terms of sex, age HDL and APRI(AST/PLT),no significant differences were found between the two groups. Table 2 showed the laboratory and clinical characteristics of varying degrees of NAFLD patients and the control group.levels of BMI,GLU,ALT,AST,TG,ALP,APRI, CHE,TG,TC,LDL,TBIL,DBIL,IBIL,TBA,HGF,PCIII and PLT were correlated With the severity of NAFLD (all P <0.05).In terms of sex, age,no significant differences were found in all groups.Moreover, the levels of HGF were significantly higher in all NAFLD group compared with Control group,But,It showed no significant difference in Mild NAFLD group and Moderate NAFLD group.In addition, PIIIP can distinguish severe NAFLD group from mild NAFLD group,moderate NAFLD group and normal group, but It showed no significant difference in mild NAFLD group and moderate NAFLD group.Even more,PLT can distinguish normal group from all NAFLD group, but It showed no significant difference in mild NAFLD group and moderate NAFLD group,so as moderate NAFLD group and severe group. Table3 showed the Correlation analysis of HGF, PCIII and PLT with various clinical parameters.When correlating HGF, PCIII and PLT with clinical parameters, PLT and HGF were correlated positively with BMI,GLU,ALT,AST,ALP,APRI,GPRI, ALB,DBIL,TBA,TG and HDL,respectively(all P <0.05).PCIII was correlated positively with BMI,GLU,AST,GPRI and LDL(all P <0.05),while it was not significantly correlated,ALT,ALP,APRI,TBA,TG and HDL. Table 4 (As shown in supplementary material S1) showed HGF, PCIII and PLT were correlated positively with Severity of NAFLD, with statistical significance. (all P <0.05). Table 5 (As shown in supplementary material S2)showed the comparison of the diagnostic performance of HGF, PCIII and PLT in patients with varying degrees of fatty liver.NAFLD patients were diagnosed by ultrasound.When an ROC curve was made to set a cut off value for HGF levels to classify grades of fatty liver, the value to differentiate mild NAFLD cases was 14.1pg/ml (AUROC 0.753,sensitivity 0.798,specificity 0.588),the value to differentiate moderate NAFLD cases was 15.4pg/ml (AUROC 0.836,Sensitivity0.833,specificity 0.696),the value to differentiate Severe NAFLD cases was 17.7pg/ml (AUROC 0.903,sensitivity 0.920,specificity 0.764).PCIII had no value in differentiate mild from moderate fatty liver,but its ability to diagnose severe fatty liver was signifificant. A cutoff value of 7.9ng/L for PCIII to diagnose severe fatty liver with a sensitivity of 96.0% and a specificity of 52.9%,and AUROC was 0.773.When an ROC curve was made to set a cut off value for PLT levels to classify grades of fatty liver, the value to differentiate mild NAFLD cases was 194 ×10^9/L(AUROC 0.548,Sensitivity 0.782,specificity 0.441),the value to differentiate moderate NAFLD cases was 195 ×10^9/L (AUROC 0.606,sensitivity0.435,specificity 0.980),the value to differentiate Severe NAFLD cases was 200 ×10^9/L (AUROC 0.790,sensitivity 0.800,specificity 0.990).When HGF,PCIII and PLT were detected together,the AUROC curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873). Fig.1 showed ROC curve analysis about the diagnostic performance of HGF in patients with different degrees of fatty liver disease. Fig.2 showed ROC curve analysis about the diagnostic performance of PCIII in patients with different degrees of fatty liver disease. Fig.3 showed ROC curve analysis about the diagnostic performance of PLT in patients with different degrees of fatty liver disease. Fig.4 showed the ROC curve analysis about the diagnostic performance of combined detection of HGF, PCIII and PLT in patients with fatty liver disease. Discussion NAFLD has become an emerging public health concern, given its remarkable growth in the worldwide over the recent decades[ 17 ].”Two hits” is the most accepted hypothesis in NAFLD.The “first hit” is closely related to insulin resistance, and the “second hit” is closely related to oxidative stress, lipid peroxidation, Immune disorders,inflammatory factors and so on[ 18 ]. NAFLD is considered to be the liver manifestation of metabolic syndrome and the prevalence of NAFLD is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus (T2DM)[ 19 ].Therefore, in addition to the changes of HGF, PCIII and PLT in NAFLD, our study also focused on their relationship with BMI, liver function, blood lipid, blood glucose and other indicators. In the liver,the major producer of HGF in the liver is hepatic stellate cell and it plays a crucial role in liver regeneration after hepatectomy or massive liver damage,protection against hepatocyte apoptosis and necrosis, and suppression of liver fibrosis progression[ 5 ].Our study also revealed significant differences between mild, moderate, and severe cases with respect to HGF, in that the more advanced the degree of fatty liver assessed by ultrasound, the higher the HGF level.That may be due to the fact that NAFLD is a chronic inflammatory state of the liver,at the initiation of the inflammatory response, IL–6 induces acute phase proteins, which are implicated in controlling the inflammation and in resetting homeostasis[ 20 ],these acute phase proteins include u-PA that promotes activation of pro-HGF to biologically active HGF[ 21 ].HGF-MET signaling can also modulate adaptive immune response by facilitating the migration of Langerhans cells and dendritic cells to draining lymph nodes[ 22 ],thus modulate inflammation in the liver.PIIINP is a collagen that reflect extracellular matrix collagen turnover[ 23 ]. In animal studies, a high-fat diet induced NASH mouse model exhibited elevated PIIINP[ 24 ]and Hamza et al. also reported that mean serum levels of PIIINP in children with NAFLD (assessed by ultrasonography) were higher than those in control children[ 25 ].Our results are consistent with previous studies and Elevated serum PIIINP has been previously been shown to be associated with elevated pro-inflammatory cytokines in liver disease[ 9 ].PLTs have a role in thrombosis formation and evidence pointing to association between PLT count and liver injury[ 26 ]. In a study, it was reported that patients with moderate-to-severe NAFLD had higher PLT counts than milder form of NAFLD[ 27 ]and PLT count has been included in some scoring systems such as NAFLD fibrosis score[ 28 ]. In addition, platelets play a pivotal role in both hepatic regeneration and fibrosis pathophysiology and Platelets contain HGF [ 29 ],Our study also found that both PLT and HGF in NAFLD increased with the increase in severity of NAFLD, which may be the protective mechanism of the liver in the inflammatory state. In addtion,HGF,PCIII and PLT may represent links between obesity, inflammation, metabolism and cardiovascular risk factors[ 30–32 ].Previous studies have also shown that recombinant HGF treatment reduced intracellular lipid content, likely by accelerating lipid secretion in hepatocytes through activation of microsomal triglyceride transfer protein and apolipoprotein B[ 33 ].Besides, recombinant HGF treatment inhibited cholesterol overload-mediated hepatocyte lipotoxicity by suppressing production of reactive oxygen species [ 34 ]. HGF is also a potent suppressor of hepatic glucose production and output in a setting of insulin resistance and that it can potentially restore insulin responsiveness[ 35 ].Quilliot D. et al. [ 36 ]showed that circulating PIIINP correlated with markers of insulin resistance and signs of impaired ventricular dysfunction in non-diabetic obese subjects.Agarwal et al. [ 31 ]demonstrated that higher blood PIIINP levels were associated with greater carotid intimamedia thickness and impaired brachial artery reactivity. Fay WP.et al.showed PLT lifespan is known to be shorter in subjects with IR, and the interactions between inflammation and thrombosis provide apotential mechanism linking PLT count and MetS[ 37 ].MPV is one of the PLT function indices which reflects the PLT production rate and stimulation and It has been reported that MPV was found significantly increased in adult patients who have diabetes, impaired fasting glucose, and hypertension[ 19 , 38 ] [ 39 ]. The current study also highlights significant correlations between HGF, PCIII,PLT and other components of the metabolic syndrome,which makes it possible for them to jointly detect NAFLD.As shown in our results, when HGF,PCIII and PLT were detected together,the AUROC curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873). Conclusion NAFLD is a common clinical diseases.combined Noninvasive monitoring of serum HGF,PCIII and PLT levels in patients with suspected NAFLD may be used as a reliable tool for early detection in order to offer proper therapy at the proper time if needed.Nevertheless, the significance of the combined detection warrants further research to be useful clinically. Abbreviations NAFLD, nonalcoholic fatty liver disease; ROC, receiver operating characteristic; SD, standard deviation; AUROC, area under the receiver operating characteristic; BMI,body mass index;AST, aspartate aminotransferase;ALT,alanine ALP,amiotransferase;Alkaline phosphatase; CHE,Serum cholinesterase;TBIL,Serum total bilirubin;DBIL,Serum direct bilirubin;IBIL,Serum indirect bilirubin;TBA,Total bile acid; TP,total protein;ALB,albumin;ALP, alkaline phosphatase; γ-GTP, γ-glutamyl transpeptidase;LP,Lipid profile;TC,Cholesterol;TG,triglycerides;HDL, High density lipoprotein;LDL,Low density lipoprotein;GLU,fasting blood glucose;HGF,Hepatocyte growth factor;PCIII,type iii procollagen;PLT,platelet. Declarations Acknowledgements We thank the Department of Otorhinolaryngology Head and Neck Tumor key Laboratory of Shanxi Province, Taiyuan, Shanxi, China. Author contributions Xiuqin An, Xiaojuan Zheng,Zhangfeng Dou,Yue Li,Yuhong Suo, Ya nan Ma, Meiqing Sun,Zhong yuan Tian and Lijun Xu were responsible for acquisition of data. Xiuqin An, Xiaojuan Zheng,Zhangfeng Dou and Yue Li were responsible for analysis and interpretation of data. Xiuqin An was responsible for drafting of the article. Xiuqin An and Jinchun Liu were responsible for study concept and design. Funding This work was supported by the science and technology department project of Shanxi provincial (No.201604D132042) and the project of shanxi provincial department of education("131" leading talents project for colleges and universities in Shanxi Province) Availability of data and materials Raw data were generated at First Hospital of Shanxi Medical University. Derived data supporting the findings of this study are available from the corresponding author [Jinchun Liu] on request. Ethics approval and consent to participate This study was approved by the Ethics committee of the First Hospital of Shanxi Medical University, which complies with the World Medical Association Declaration of Helsinki regarding ethical conduct of research involving human subjects and/or animals.All patients provided a written informed consent prior to inclusion in the study. Consent for publication Not Applicable Competing interests The authors declare that they have no conflict of interest. Author details 1, *Department of Gastroenterology, First hospital of Shanxi Medical University, Jiefang Road South 85th, Taiyuan, Shanxi 030001, P.R. China. References 1.Diehl AM, Day C. Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis. The New England journal of medicine. 2017;377(21):2063–72. 2.Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. 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A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nature medicine. 2011;17(12):1577–84. 36.Quilliot D, Alla F, Bohme P, Bruntz JF, Hammadi M, Dousset B, et al. Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance. International journal of obesity. 2005;29(11):1321–8. 37.Fay WP. Linking inflammation and thrombosis: Role of C-reactive protein. World journal of cardiology. 2010;2(11):365–9. 38.Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. Correlation between mean platelet volume and blood glucose levels after oral glucose loading in normoglycemic and prediabetic Japanese subjects. Journal of diabetes investigation. 2014;5(1):66–71. 39.Gang L, Yanyan Z, Zhongwei Z, Juan D. Association between mean platelet volume and hypertension incidence. Hypertension research: official journal of the Japanese Society of Hypertension. 2017;40(8):779–84. Tables Table 1. Clinical ,laboratory, and anthropometric data of NAFLD patients compared to controls Control group NAFLD group Statistics P Male/female 52/50 156/144 = 0.032 0.859 age 54.97 ± 12.32 54.19 ± 13.71 t =0.050 0.614 BMI (kg/m 2 ) 23.96 ± 2.36 27.04 ± 3.71 t =-7.864 0.000 GLU (mmol/L) 7.48 ± 4.13 9.29 ± 25.71 Z =-2.131 0.033 PLT ( 10^9/L ) 169.72 ± 60.82 201.78 ± 66.36 Z =-4.286 0.000 ALT (IU/L) 22.69 ± 13.05 36.02 ± 43.16 Z =-3.753 0.000 AST (IU/L) 23.53 ± 9.94 33.207 ± 26.83 Z =-3.670 0.000 ALP (U/L) 89.95 ± 78.75 107.55 ± 100.25 Z =-2.254 0.024 APRI(AST/PLT) 0.16 ± 0.105 0.17 ± 0.14 Z =-0.370 0.711 GPRI(GGT/PLT) 0.206 ± 0.23 0.27 ± 0.49 Z =-0.043 0.010 GGT(U//L) 39.80 ± 48.96 48.28 ± 75.14 Z =-2.488 0.013 CHE(mmol/L) 7.41 ± 1.65 8.36 ± 4.27 t =-2.20 0.028 TP(g/L) 7.41 ± 1.65 8.36 ± 4.28 Z =-2.03 0.043 ABL(g/L) 47.039 ± 6.07 42.29 ± 6.16 Z =-5.463 0.000 TBIL(umol/L) 12.67 ± 11.42 14.86 ± 7.44 Z =-4.963 0.000 DBIL(umol/L) 2.17 ± 1.19 2.94 ± 2.69 Z =-3.604 0.000 IBIL(umol/L) 8.99 ± 3.51 11.24 ± 5.41 Z =-4.447 0.000 TBA (mmol/L) 5.322 ± 4.46 7.83 ± 9.44 Z =-2.639 0.008 TC(mmol/L) 4.422 ± 1.19 4.87 ± 1.39 t =-2.905 0.004 TG(mmol/L) 1.95 ± 1.24 2.45 ± 2.12 Z =-2.992 0.003 LDL (mmol/L) 2.49 ± 0.81 2.72 ± 0.86 t =-2.406 0.017 HDL (mmol/L) 1.03 ± 0.34 1.11 ± 0.56 Z =-0.771 0.441 HGF （ pg/ml ） 33.18 ± 34.85 56.45 ± 97.30 Z =-3.132 0.002 PCIII （ ng/ml ） 7.82 ± 7.69 15.11 ± 13.31 Z =-4.476 0.000 Table 2. the laboratory and clinical characteristics of varying degrees of NAFLD patients and the control group Control group （ n=102 ） Mild （ n=119 ） Moderate （ n=156 ） Severe （ n=25 ） Statistics P Male/female 52/50 58/61 81/75 17/8 =3.102 0.376 age 54.97±12.32 53.95±13.66 54.96±13.68 50.64±14.09 F =0.856 0.464 BMI(kg/m2) 23.96±2.36 23.63±2.83 28.63±1.26 a 33.40±2.34 ab F =247.176 0.000 GLU(mmol/L) 5.76 （ 5.00 -8.58 ） 6.20 (5.06-9.35) a 7.50 (5.85-9.62) ab 6.19 (5.07-7.78) a H = 15.134 0.002 ALT(IU/L) 20.00 （ 14.75 - 28.25 ） 22.00 (15.00-50.00) 26.00 ab (16.00-44.75) 21.00 (15.00-38.00) H = 14.977 0.002 AST(IU/L) 22.00 (17.75-27.00) 26.00 a (19.00-35.00) 23.00 (18.00-35.75) 50.00 a (24.00-55.00) H = 30.09 0.000 ALP(U/L) 83.00 (63.75-98.25) 87.00 a (71.00-108.00) 82.00 (70.00-103.25) 102.00 abc (96.00-112.00) H = 15.58 0.001 APRI(AST/PLT) 0.14 (0.10-0.20) 0.13 (0.09-0.21) 0.13 (0.096-0.19) 0.21 abc (0.14-0.24) H = 11.15 0.011 GPRI(GGT/PLT) 0.12 (0.09-0.22) 0.16 a (0.10-0.31) 0.17 a (0.11-0.27) 0.13 (0.10-0.18) H = 9.18 0.027 GGT(U//L) 23.00 (16.00-39.25) 28.00 a (20.00-59.00) 29.00 a (19.00-52.75) 27.00 (17.50-38.00) H = 8.21 0.042 CHE(mmol/L) 8.28±7.43 8.40±6.06 ac 8.00±3.14 8.11±1.15 F =3.481 0.016 TP(g/L) 67.20 (62.95-72.23) 68.40 a (64.10-73.5) 67.90 (63.96-73.08) 67.80 (65.75-73.05) H = 8.50 0.020 ALB(g/L) 43.15 (39.88-46.10) 42.80 a (39.60-45.30) 42.80 a (40.60-46.20) 43.10 (42.30-46.20) H = 30.95 0.000 TBIL(umol/L) 12.20 (9.10-16.75) 11.10 (9.70-16.30) 12.80 (10.50-15.82) 13.70 b (11.15-19.85) H = 36.269 0.000 DBIL(umol/L) 2.10 (1.50-3.00) 2.10 (1.60-3.20) 2.30 a (1.90-3.00) 2.10 (1.80-2.80) H = 14.368 0.002 IBIL(umol/L) 9.45 (7.08-13.98) 8.80 (7.70-13.10) 10.45 (8.10-12.30) 11.20 b (9.50-16.55) H = 26.493 0.000 TBA(mmol/L) 4.50 (2.40-7.35) 4.70 (2.60-9.20) 4.60 (2.80-8.17) 3.70 abc (2.95-5.45) H = 10.747 0.013 TC(mmol/L) 4.42±1.19 4.31±1.38 4.56±1.38 4.88±1.00 b F =3.578 0.014 TG(mmol/L) 1.60 (1.20-2.30) 1.60 (1.12-2.62) 1.86 (1.31-2.59) 1.95 ab (1.42-2.38) H = 9.098 0.028 LDL(mmol/L) 2.49±0.81 2.72±0.88 a 2.71±0.87 2.79±0.78 a F =3.412 0.026 HDL(mmol/L) 0.97 (0.84-1.16) 1.02 (0.85-1.19) 0.97 (0.85-1.09) 1.23 ac (0.91-1.30) H = 6.801 0.079 HGF(pg/m)l 18.22 (11.44-44.22) 23.85 (14.35-53.44) a 26.26 (15.69-99.84) a 35.29 (13.43-52.94) abc H = 11.364 0.010 PCIII( ng/ml ) 5.74 (0.34-23.10) 6.62 (0.52-12.00) 8.19 a (1.84-24.61) a 16.13 abc (8.36-26.28) H = 33.347 0.000 PLT( 10^9/L ) 165.00 (103.75-211.00) 185.00 (152.00-224.25) a 200.00 (166.00-258.00) a 203.00 (166.00-240.00) ab H = 24.38 0.000 Note: a: there was a statistically significant difference from the norma l control group, there was a statistical difference. b: there was a statistically significant difference from the mild fatty liver group; C: there was a statistically significant difference from the moderate fatty liver group. Table 3. Correlation analysis of HGF, PCIII and homa-ir with various clinical parameters HGF PCIII PLT r P r P r P age 0.056 0.612 0.165 0.137 0.066 0.554 BMI 0.432 <0.001 0.311 0.004 0.373 0.001 GLU 0.305 0.005 0.152 0.170 0.261 0.017 ALT 0.403 <0.001 0.109 0.328 0.391 <0.001 AST 0.465 <0.001 0.227 0.039 0.472 <0.001 ALP 0.305 0.005 0.152 0.170 0.261 0.017 APRI 0.415 <0.001 0.109 0.328 0.398 <0.001 GPRI 0.488 <0.001 0.226 0.040 0.443 <0.001 GGT 0.285 0.009 0.112 0.315 0.242 0.027 CHE 0.125 0.262 0.135 0.235 0.138 0.215 TP 0.163 0.142 0.007 0.948 0.084 0.449 ABL 0.378 <0.001 0.180 0.104 0.251 0.022 TBIL 0.163 0.142 0.007 0.948 0.084 0.449 DBIL 0.378 <0.001 0.180 0.104 0.251 0.022 IBIL 0.262 0.017 0.222 0.043 0.222 0.044 TBA 0.322 0.003 0.164 0.139 0.954 <0.001 TC 0.162 0.148 0.007 0.948 0.084 0.449 TG 0.398 <0.001 0.180 0.104 0.251 0.022 LDL 0.269 0.017 0.228 0.041 0.221 0.047 HDL 0.329 0.003 0.169 0.146 0.901 <0.001 Table 4 The relationship between HGF, PCIII and PLT and the degree of NAFLD r P HGF 0.501 <0.001 PCIII 0.397 <0.001 PLT 0.470 <0.001 Table 5 The comparison of the diagnostic performance of HGF, PCIII and PLT in patients with varying degrees of fatty liver group AUC （ 95%CI ） cut-off SE SP P HGF （ pg/ml ） Mild 0.753 （ 0.691-0.809 ） 14.1 0.798 0.588 0.004 Moderate 0.836 （ 0.785-0.879 ） 15.4 0.833 0.696 <0.001 Severe 0.903 （ 0.837-0.948 ） 17.7 0.920 0.764 <0.001 PC Ⅲ （ ng/ml ） Mild 0.597 （ 0.529-0.662 ） 7.9 0.697 0.568 0.114 Moderate 0.628 （ 0.566-0.687 ） 7.8 0.698 0.558 0.086 Severe 0.773 （ 0.690-0.842 ） 7.9 0.960 0.529 <0.001 PLT (10^9/L) Mild 0.732 (0.669-0.789) 194 0.782 0.441 <0.001 Moderate 0.765 （ 0.709-0.816 ） 195 0.435 0.980 <0.001 Severe 0.925 （ 0.865-0.965 ） 200 0.800 0.990 <0.001 note ： SE ： sensitivity ； SP ： specificity Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8663","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":233560,"identity":"7da6abc2-1272-4067-86b7-f721dcf663d9","order_by":1,"name":"Xiuqin An","email":"","orcid":"","institution":"First Hospital of Shanxi Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiuqin","middleName":"","lastName":"An","suffix":""},{"id":233561,"identity":"6c5fedbf-256b-4fb7-820e-cb665a77e3e0","order_by":2,"name":"Jinchun Liu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA0ElEQVRIie3QsQrCMBDG8YRAumTQLS71CYSTQifRV+kh1Elw7KZFuC51r/geztWCLr6A4JAszo6OOgvSuDnkN3//4Y4xz/tP3CQwCnmR5/bhmAgwWRqJsllH2jGRXXM5YlHNqKNc9v1qfmdINd9sLTHNxuFg1ZLw8hwbpJvo7ZDMgk2juG5JREABIN3lcIcFaFbjvi2RQkqN1KjJ9UBauSQqIKmTS6N5xR0TrU4CkiwFXuL7yeBwS79KuX3CaJkXZ2sf2ThsTT7Ab3PP8zzvixdxCkOjcOf2fQAAAABJRU5ErkJggg==","orcid":"","institution":"First Hospital of Shanxi Medical University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Jinchun","middleName":"","lastName":"Liu","suffix":""},{"id":233562,"identity":"6bb6f86c-3311-4a74-bcd0-6e0e62dd5e4c","order_by":3,"name":"Xiaojuan Zheng","email":"","orcid":"","institution":"First Hospital of Shanxi Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiaojuan","middleName":"","lastName":"Zheng","suffix":""},{"id":233566,"identity":"2e664cfe-56e5-4cba-b449-e7dd3010aa5e","order_by":4,"name":"Zhangfeng Dou","email":"","orcid":"","institution":"First Hospital of Shanxi Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhangfeng","middleName":"","lastName":"Dou","suffix":""},{"id":233567,"identity":"3dab0293-8925-432b-8139-26c6a574c385","order_by":5,"name":"Yue Li","email":"","orcid":"","institution":"First Hospital of Shanxi Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yue","middleName":"","lastName":"Li","suffix":""},{"id":233568,"identity":"e474a945-cfd9-4742-bcbf-ef131331630b","order_by":6,"name":"Yuhong Suo","email":"","orcid":"","institution":"First Hospital of Shanxi Medical 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University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhong","middleName":"Yuan","lastName":"Tian","suffix":""},{"id":233572,"identity":"b65c0449-8eb4-40a8-9b6f-37bba8fc38aa","order_by":10,"name":"Lijun Xu","email":"","orcid":"","institution":"First Hospital of Shanxi Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lijun","middleName":"","lastName":"Xu","suffix":""}],"badges":[],"createdAt":"2019-11-29 12:57:43","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.18035/v1","doiUrl":"https://doi.org/10.21203/rs.2.18035/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":206113,"identity":"d7d46475-b4dd-4c0f-93cf-0fc43d1bb0f4","added_by":"auto","created_at":"2019-12-04 22:17:53","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":50923,"visible":true,"origin":"","legend":"showed ROC curve analysis about the diagnostic performance of HGF in patients with different degrees of fatty liver disease.","description":"","filename":"1.PNG","url":"https://assets-eu.researchsquare.com/files/9d3b99ec-0847-4cbf-8441-8ef7b2f0ebed/v1/1.PNG"},{"id":206115,"identity":"e546081c-a882-4a30-992a-4b2bcbace035","added_by":"auto","created_at":"2019-12-04 22:17:54","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":52534,"visible":true,"origin":"","legend":"showed ROC curve analysis about the diagnostic performance of PCIII in patients with different degrees of fatty liver disease.","description":"","filename":"2.PNG","url":"https://assets-eu.researchsquare.com/files/9d3b99ec-0847-4cbf-8441-8ef7b2f0ebed/v1/2.PNG"},{"id":206116,"identity":"5c5164e4-c1c3-413c-bfb5-1f213cdcc786","added_by":"auto","created_at":"2019-12-04 22:17:54","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":50337,"visible":true,"origin":"","legend":"showed ROC curve analysis about the diagnostic performance of PLT in patients with different degrees of fatty liver disease.","description":"","filename":"3.PNG","url":"https://assets-eu.researchsquare.com/files/9d3b99ec-0847-4cbf-8441-8ef7b2f0ebed/v1/3.PNG"},{"id":206117,"identity":"4558bfcb-30ed-416b-96d8-c2998c3279f8","added_by":"auto","created_at":"2019-12-04 22:17:54","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":19074,"visible":true,"origin":"","legend":"showed the ROC curve analysis about the diagnostic performance of combined detection of HGF, PCIII and PLT in patients with fatty liver disease.","description":"","filename":"4.PNG","url":"https://assets-eu.researchsquare.com/files/9d3b99ec-0847-4cbf-8441-8ef7b2f0ebed/v1/4.PNG"},{"id":13480768,"identity":"e310e9d5-2cda-4a27-9e19-d6d7c65c0cf8","added_by":"auto","created_at":"2021-09-16 21:44:44","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":430594,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8663/v1/bf404b7c-f6ac-4895-9734-cc5c7c6d1311.pdf"}],"financialInterests":"","formattedTitle":"Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease","fulltext":[{"header":"Introduction","content":"\u003cp\u003eNon-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome, which is characterized by excessive accumulation of fat content in hepatocytes. The spectrum of NAFLD disease includes nonalcoholic simple fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), liver fibrosis, liver cirrhosis and liver cancer. Numerous risk factors are associated with the development and progression of NAFLD, including obesity, visceral obesity, insulin resistance and features of the metabolic syndrom[\u003ca href=\"#_ENREF_1\"\u003e1\u003c/a\u003e].The worldwide prevalence of NAFLD is currently estimated to be in the range of 6% to 37%, with a reported pooled overall global prevalence of 25%[\u003ca href=\"#_ENREF_2\"\u003e2\u003c/a\u003e],As the global epidemic of NAFLD, the clinical and economic burden of NAFLD will become enormous.Although Liver biopsy is the gold standard for the diagnosis, grading, and staging in patients with NAFLD, but it has its own limitations, such as the risk of sampling error, high rates of inter- and intraobserver differences, risk of complications, and the high cost and so on[\u003ca href=\"#_ENREF_3\"\u003e3\u003c/a\u003e]. Thus, it is important to develop efficient noninvasive diagnostic methods for NAFLD and numerous noninvasive diagnostic method have been developed worldwide.\u003c/p\u003e\n\u003cp\u003eHepatocyte growth factor (HGF) is a multifunctional pleiotropic cytokine,is not only an anti-apoptotic and anti-fibrotic factor in the liver, but also a adipokine[\u003ca href=\"#_ENREF_4\"\u003e4\u003c/a\u003e].HGF is initially produced as a biologically inactive, single-chain precursor form,After proteolytic cleavage,it converts to the active form to Participate in various physiological activities[\u003ca href=\"#_ENREF_5\"\u003e5\u003c/a\u003e].Tojima[\u003ca href=\"#_ENREF_6\"\u003e6\u003c/a\u003e]et al. showed that HGF overexpression could alleviate the pathological changes of hepatitis and liver fibrosis in a murine model of NASH induced by methionine-choline deficiency (MCD) diet due to its antioxidant, antiapoptotic and plasminolytic effects. Kroy DC[\u003ca href=\"#_ENREF_7\"\u003e7\u003c/a\u003e]et al. also demonstrated the protective role of HGF in the development of NAFLD by by knocking out of HGF receptor cMet in mouse hepatocytes.In addition, previous studies found that HGF was significantly high in patients with NASH and it correlated with Various parameters of metabolic syndrome[\u003ca href=\"#_ENREF_4\"\u003e4\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eThe development of hepatic fibrosis is an important event in the progression of liver disease. Serum type III procollagen peptide (PIIIP), a degradation product of the type III collagen precursor and has been shown to be a negative prognostic factor in chronic hepatitis[\u003ca href=\"#_ENREF_8\"\u003e8\u003c/a\u003e].Serum PIIINP levels increased significantly along with the increasing severity of liver inflammation[\u003ca href=\"#_ENREF_9\"\u003e9\u003c/a\u003e].Procollagen-III peptide also could identify adipose tissue(AT)-associated inflammation in type 2 diabetes with or without nonalcoholic liver disease,Higher PIIINP levels correlated with greater BMI and visceral AT area and were associated with systemic signatures of AT-associated inflammation[\u003ca href=\"#_ENREF_10\"\u003e10\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eThe platelet is the primary cell for hemostasis and tissue repair.Many studies have shown that PLT plays a role in the inflammatory response after hepatic damage[\u003ca href=\"#_ENREF_11\"\u003e11\u003c/a\u003e, \u003ca href=\"#_ENREF_12\"\u003e12\u003c/a\u003e].Recent clinical and experimental evidences also support that platelets play several roles in the progression of malignancies and inversely, cancer can also influence platelet count and activity[\u003ca href=\"#_ENREF_13\"\u003e13\u003c/a\u003e].Sangbin Han et al. ‘s findings suggested that platelets play an important role in HCC cells metastasis and preoperative platelet count was independently correlated with post-transplant HCC recurrence[\u003ca href=\"#_ENREF_14\"\u003e14\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eThus, the current study attempted to evaluate the clinical utility of serum HGF,PIIIP and PLT levels in the diagnosis of suspected NAFLD.\u003c/p\u003e\n\n"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003ePatients and methods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA total of 300 patients diagnosed with NAFLD and 102 sex- and age-matched healthy volunteers without NAFLD were included in this study from Novemble 2016 to Novemble 2018. All patients were diagnosed with NAFLD based on ultrasound imaging made under fasting conditions.The grade of fatty liver was categorized as follows: (1) mild steatosis: increased echogenicity of the liver as compared with the renal cortex or spleen; (2) moderate steatosis: obscured hepatic and portal vein walls, and (3) severe steatosis: impaired visibility of the diaphragm[\u003ca href=\"#_ENREF_15\"\u003e15\u003c/a\u003e].Subjects with a history of excessive alcohol consumption (weekly consumption of \u0026ge;140 g for men or \u0026ge;70 g for women), other liver diseases such as chronic hepatitis, or use of drugs known to be associated with the development of fatty liver, body weight reduction or thyroid disorders were excluded[\u003ca href=\"#_ENREF_16\"\u003e16\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp; Physical examination of each patient included body weight, height,calculation of body mass index (BMI) .Blood samples were collected after 12 hours of fasting,the serum was obtained after centrifugation at 3000 RPM for 15min and Stored in a - 80℃ low temperature refrigerator.Analyses included liver function tests(AST, ALT, CHE, TBIL,DBIL,IBIL,TBA, TP,ALB and ALP), lipid profile（TC,TG,HDL,LDL）, GLU,HGF,PCIII and PLT. The HGF, PIIIP were assayed using ELISA kit purchased from WuHan Elliot biotechnology co. LTD.Other biochemical indicators were detected by automatic biochemical instrument purchased from Beijing anxin haichuang technology co,LTD.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA statistical analysis was performed using Medcalc 19.0. The measurement data conforming to the normal distribution were expressed by mean \u0026plusmn; standard deviation (SD).T- test was used for comparison between two groups.Univariate anova was used for multigroup comparison and Lsd-t test was used for further pairwise comparison.\u003c/p\u003e\n\u003cp\u003eThe measurement data of non-normal distribution were expressed by [M (p25-p75)], mann-whitneyu test was used for comparison between two groups, and kruskal-wallis H test was used for comparison between multiple groups.X\u003csup\u003e2\u003c/sup\u003e test was used to compare counting data between groups. The area under the ROC curve (AUC) was calculated, and its diagnostic validity was tested by Z test, and the optimal cut-off value (YI=Se+ sp-1) was determined by Jordan index.\u003cem\u003eP\u003c/em\u003e\u0026lt;0.001 was considered statistically significant.Spearman rank correlation analysis was used to analyze the correlation between HGF, PCIII ,PLT and clinical parameters and severity of NAFLD (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eTable 1 showed the laboratory and clinical characteristics of NAFLD patients and the control group.Levels of BMI,GLU,ALT,AST,TG,ALP,GGT,GPRI(GGT/PLT),\u003c/p\u003e\n\u003cp\u003eDBIL,IBIL,TBA,TP,HGF,PCIII and PLT were significantly higher in the NAFLD patients compared with the control group,ALB was significantly lower in the NAFLD patients compared with the control group,(all \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).In terms of sex, age HDL and APRI(AST/PLT),no significant differences were found between the two groups.\u003c/p\u003e\n\n\u003cp\u003eTable 2 showed the laboratory and clinical characteristics of varying degrees of NAFLD patients and the control group.levels of BMI,GLU,ALT,AST,TG,ALP,APRI,\u003c/p\u003e\n\u003cp\u003eCHE,TG,TC,LDL,TBIL,DBIL,IBIL,TBA,HGF,PCIII and PLT were correlated With\u003c/p\u003e\n\u003cp\u003ethe severity of NAFLD (all \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).In terms of sex, age,no significant differences were found in all groups.Moreover, the levels of HGF were significantly higher in all NAFLD group compared with Control group,But,It showed no significant difference in Mild NAFLD group and Moderate NAFLD group.In addition, PIIIP can distinguish severe NAFLD group from mild NAFLD group,moderate NAFLD group and normal group, but It showed no significant difference in mild NAFLD group and moderate NAFLD group.Even more,PLT can distinguish normal group from all NAFLD group, but It showed no significant difference in mild NAFLD group and moderate NAFLD group,so as moderate NAFLD group and severe group.\u003c/p\u003e\n\n\u003cp\u003eTable3 showed the Correlation analysis of HGF, PCIII and PLT with various clinical parameters.When correlating HGF, PCIII and PLT with clinical parameters, PLT and HGF were correlated positively with BMI,GLU,ALT,AST,ALP,APRI,GPRI,\u003c/p\u003e\n\u003cp\u003eALB,DBIL,TBA,TG and HDL,respectively(all \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).PCIII was correlated positively with BMI,GLU,AST,GPRI and LDL(all \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05),while it was not significantly correlated,ALT,ALP,APRI,TBA,TG and HDL.\u003c/p\u003e\n\n\u003cp\u003eTable 4 (As shown in supplementary material S1) showed HGF, PCIII and PLT were correlated positively with Severity of NAFLD, with statistical significance. (all \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/p\u003e\n\n\u003cp\u003eTable 5 (As shown in supplementary material S2)showed the comparison of the diagnostic performance of HGF, PCIII and PLT in patients with varying degrees of fatty liver.NAFLD patients were diagnosed by ultrasound.When an ROC curve was made to set a cut off value for HGF levels to classify grades of fatty liver, the value to differentiate mild NAFLD cases was 14.1pg/ml (AUROC 0.753,sensitivity 0.798,specificity 0.588),the value to differentiate moderate NAFLD cases was 15.4pg/ml (AUROC 0.836,Sensitivity0.833,specificity 0.696),the value to differentiate Severe NAFLD cases was 17.7pg/ml (AUROC 0.903,sensitivity 0.920,specificity 0.764).PCIII had no value in differentiate mild from moderate fatty liver,but its ability to diagnose severe fatty liver was signifificant. A cutoff value of 7.9ng/L for PCIII to diagnose severe fatty liver with a sensitivity of 96.0% and a specificity of 52.9%,and AUROC was 0.773.When an ROC curve was made to set a cut off value for PLT levels to classify grades of fatty liver, the value to differentiate mild NAFLD cases was 194 ×10^9/L(AUROC 0.548,Sensitivity 0.782,specificity 0.441),the value to differentiate moderate NAFLD cases was 195 ×10^9/L (AUROC 0.606,sensitivity0.435,specificity 0.980),the value to differentiate Severe NAFLD cases was 200 ×10^9/L (AUROC 0.790,sensitivity 0.800,specificity 0.990).When HGF,PCIII and PLT were detected together,the AUROC curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873).\u003c/p\u003e\n\n\u003cp\u003eFig.1 showed ROC curve analysis about the diagnostic performance of HGF in patients with different degrees of fatty liver disease.\u003c/p\u003e\n\u003cp\u003eFig.2 showed ROC curve analysis about the diagnostic performance of PCIII in patients with different degrees of fatty liver disease.\u003c/p\u003e\n\u003cp\u003eFig.3 showed ROC curve analysis about the diagnostic performance of PLT in patients with different degrees of fatty liver disease.\u003c/p\u003e\n\u003cp\u003eFig.4 showed the ROC curve analysis about the diagnostic performance of combined detection of HGF, PCIII and PLT in patients with fatty liver disease.\u003c/p\u003e\n"},{"header":"Discussion","content":"\u003cp\u003eNAFLD has become an emerging public health concern, given its remarkable growth in the worldwide over the recent decades[\u003ca href=\"#_ENREF_17\"\u003e17\u003c/a\u003e].”Two hits” is the most accepted hypothesis in NAFLD.The “first hit” is closely related to insulin resistance, and the “second hit” is closely related to oxidative stress, lipid peroxidation, Immune disorders,inflammatory factors and so on[\u003ca href=\"#_ENREF_18\"\u003e18\u003c/a\u003e]. NAFLD is considered to be the liver manifestation of metabolic syndrome and the prevalence of NAFLD is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus (T2DM)[\u003ca href=\"#_ENREF_19\"\u003e19\u003c/a\u003e].Therefore, in addition to the changes of HGF, PCIII and PLT in NAFLD, our study also focused on their relationship with BMI, liver function, blood lipid, blood glucose and other indicators.\u003c/p\u003e\n\u003cp\u003eIn the liver,the major producer of HGF in the liver is hepatic stellate cell and it plays a crucial role in liver regeneration after hepatectomy or massive liver damage,protection against hepatocyte apoptosis and necrosis, and suppression of liver fibrosis progression[\u003ca href=\"#_ENREF_5\"\u003e5\u003c/a\u003e].Our study also revealed significant differences between mild, moderate, and severe cases with respect to HGF, in that the more advanced the degree of fatty liver assessed by ultrasound, the higher the HGF level.That may be due to the fact that NAFLD is a chronic inflammatory state of the liver,at the initiation of the inflammatory response, IL–6 induces acute phase proteins, which are implicated in controlling the inflammation and in resetting homeostasis[\u003ca href=\"#_ENREF_20\"\u003e20\u003c/a\u003e],these acute phase proteins include u-PA that promotes activation of pro-HGF to biologically active HGF[\u003ca href=\"#_ENREF_21\"\u003e21\u003c/a\u003e].HGF-MET signaling can also modulate adaptive immune response by facilitating the migration of Langerhans cells and dendritic cells to draining lymph nodes[\u003ca href=\"#_ENREF_22\"\u003e22\u003c/a\u003e],thus modulate inflammation in the liver.PIIINP is a collagen that reflect extracellular matrix collagen turnover[\u003ca href=\"#_ENREF_23\"\u003e23\u003c/a\u003e]. In animal studies, a high-fat diet induced NASH mouse model exhibited elevated PIIINP[\u003ca href=\"#_ENREF_24\"\u003e24\u003c/a\u003e]and Hamza et al. also reported that mean serum levels of PIIINP in children with NAFLD (assessed by ultrasonography) were higher than those in control children[\u003ca href=\"#_ENREF_25\"\u003e25\u003c/a\u003e].Our results are consistent with previous studies and Elevated serum PIIINP has been previously been shown to be associated with elevated pro-inflammatory cytokines in liver disease[\u003ca href=\"#_ENREF_9\"\u003e9\u003c/a\u003e].PLTs have a role in thrombosis formation and evidence pointing to association between PLT count and liver injury[\u003ca href=\"#_ENREF_26\"\u003e26\u003c/a\u003e]. In a study, it was reported that patients with moderate-to-severe NAFLD had higher PLT counts than milder form of NAFLD[\u003ca href=\"#_ENREF_27\"\u003e27\u003c/a\u003e]and PLT count has been included in some scoring systems such as NAFLD fibrosis score[\u003ca href=\"#_ENREF_28\"\u003e28\u003c/a\u003e]. In addition, platelets play a pivotal role in both hepatic regeneration and fibrosis pathophysiology and Platelets contain HGF [\u003ca href=\"#_ENREF_29\"\u003e29\u003c/a\u003e],Our study also found that both PLT and HGF in NAFLD increased with the increase in severity of NAFLD, which may be the protective mechanism of the liver in the inflammatory state.\u003c/p\u003e\n\u003cp\u003eIn addtion,HGF,PCIII and PLT may represent links between obesity, inflammation, metabolism and cardiovascular risk factors[\u003ca href=\"#_ENREF_30\"\u003e30–32\u003c/a\u003e].Previous studies have also shown that recombinant HGF treatment reduced intracellular lipid content, likely by accelerating lipid secretion in hepatocytes through activation of microsomal triglyceride transfer protein and apolipoprotein B[\u003ca href=\"#_ENREF_33\"\u003e33\u003c/a\u003e].Besides, recombinant HGF treatment inhibited cholesterol overload-mediated hepatocyte lipotoxicity by suppressing production of reactive oxygen species [\u003ca href=\"#_ENREF_34\"\u003e34\u003c/a\u003e]. HGF is also a potent suppressor of hepatic glucose production and output in a setting of insulin resistance and that it can potentially restore insulin responsiveness[\u003ca href=\"#_ENREF_35\"\u003e35\u003c/a\u003e].Quilliot D. et al. [\u003ca href=\"#_ENREF_36\"\u003e36\u003c/a\u003e]showed that circulating PIIINP correlated with markers of insulin resistance and signs of impaired ventricular dysfunction in non-diabetic obese subjects.Agarwal et al. [\u003ca href=\"#_ENREF_31\"\u003e31\u003c/a\u003e]demonstrated that higher blood PIIINP levels were associated with greater carotid intimamedia thickness and impaired brachial artery reactivity. Fay \u003ca href=\"http://WP.et\"\u003eWP.et\u003c/a\u003e al.showed PLT lifespan is known to be shorter in subjects with IR, and the interactions between inflammation and thrombosis provide apotential mechanism linking PLT count and MetS[\u003ca href=\"#_ENREF_37\"\u003e37\u003c/a\u003e].MPV is one of the PLT function indices which reflects the PLT production rate and stimulation and It has been reported that MPV was found significantly increased in adult patients who have diabetes, impaired fasting glucose, and hypertension[\u003ca href=\"#_ENREF_19\"\u003e19\u003c/a\u003e, \u003ca href=\"#_ENREF_38\"\u003e38\u003c/a\u003e] [\u003ca href=\"#_ENREF_39\"\u003e39\u003c/a\u003e]. The current study also highlights significant correlations between HGF, PCIII,PLT and other components of the metabolic syndrome,which makes it possible for them to jointly detect NAFLD.As shown in our results, when HGF,PCIII and PLT were detected together,the AUROC curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873).\u003c/p\u003e\n\n"},{"header":"Conclusion","content":"\u003cp\u003eNAFLD is a common clinical diseases.combined Noninvasive monitoring of serum HGF,PCIII and PLT levels in patients with suspected NAFLD may be used as a reliable tool for early detection in order to offer proper therapy at the proper time if needed.Nevertheless, the significance of the combined detection warrants further research to be useful clinically.\u003c/p\u003e\n"},{"header":"Abbreviations","content":"\u003cp\u003eNAFLD, nonalcoholic fatty liver disease; ROC, receiver operating characteristic; SD, standard deviation; AUROC, area under the receiver operating characteristic; BMI,body mass index;AST, aspartate aminotransferase;ALT,alanine ALP,amiotransferase;Alkaline phosphatase; CHE,Serum cholinesterase;TBIL,Serum total bilirubin;DBIL,Serum direct bilirubin;IBIL,Serum indirect bilirubin;TBA,Total bile acid; TP,total protein;ALB,albumin;ALP, alkaline phosphatase; γ-GTP, γ-glutamyl transpeptidase;LP,Lipid profile;TC,Cholesterol;TG,triglycerides;HDL, High density lipoprotein;LDL,Low density lipoprotein;GLU,fasting blood glucose;HGF,Hepatocyte growth factor;PCIII,type iii procollagen;PLT,platelet.\u003c/p\u003e\n"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u0026nbsp; \u003c/strong\u003eWe thank the Department of Otorhinolaryngology Head and Neck Tumor key Laboratory of Shanxi Province, Taiyuan, Shanxi, China.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eXiuqin An, Xiaojuan Zheng,Zhangfeng Dou,Yue Li,Yuhong Suo, Ya nan Ma, Meiqing Sun,Zhong yuan Tian and Lijun Xu were responsible for acquisition of data. Xiuqin An, Xiaojuan Zheng,Zhangfeng Dou and Yue Li were responsible for analysis and interpretation of data. Xiuqin An was responsible for drafting of the article. Xiuqin An and Jinchun Liu were responsible for study concept and design.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by the science and technology department project of Shanxi provincial (No.201604D132042) and the project of shanxi provincial department of education(\"131\" leading talents project for colleges and universities in Shanxi Province)\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eRaw data were generated at First Hospital of Shanxi Medical University. Derived data supporting the findings of this study are available from the corresponding author [Jinchun Liu] on request.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Ethics committee of the First Hospital of Shanxi Medical University, which complies with the World Medical Association Declaration of Helsinki regarding ethical conduct of research involving human subjects and/or animals.All patients provided a written informed consent prior to inclusion in the study.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot Applicable\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor details\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e1,\u003c/sup\u003e*Department of Gastroenterology, First hospital of Shanxi Medical University,\u0026nbsp; Jiefang Road South 85th, Taiyuan, Shanxi 030001, P.R. China.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e1.Diehl AM, Day C. Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis. The New England journal of medicine. 2017;377(21):2063–72.\u003c/p\u003e\n\u003cp\u003e2.Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84.\u003c/p\u003e\n\u003cp\u003e3.Sumida Y, Nakajima A, Itoh Y. Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World journal of gastroenterology. 2014;20(2):475–85.\u003c/p\u003e\n\u003cp\u003e4.Agrawal RP, Sheroan V, Ola V, Sulemani AA, Singh N, Sirohi P, et al. Hepatocyte growth factor, adiponectin and hepatic histopathology in non-alcoholic steatohepatitis. 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Low fibrosis biomarker levels predict cardiac resynchronization therapy response. Scientific reports. 2019;9(1):6103.\u003c/p\u003e\n\u003cp\u003e31.He S, Lei W, Li J, Yu K, Yu Y, Zhou L, et al. Relation of Platelet Parameters With Incident Cardiovascular Disease (The Dongfeng-Tongji Cohort Study). The American journal of cardiology. 2019;123(2):239–48.\u003c/p\u003e\n\u003cp\u003e32.Bell EJ, Decker PA, Tsai MY, Pankow JS, Hanson NQ, Wassel CL, et al. Hepatocyte growth factor is associated with progression of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2018;272:162–7.\u003c/p\u003e\n\u003cp\u003e33.Kosone T, Takagi H, Horiguchi N, Ariyama Y, Otsuka T, Sohara N, et al. HGF ameliorates a high-fat diet-induced fatty liver. American journal of physiology Gastrointestinal and liver physiology. 2007;293(1):G204–10.\u003c/p\u003e\n\u003cp\u003e34.Dominguez-Perez M, Nuno-Lambarri N, Clavijo-Cornejo D, Luna-Lopez A, Souza V, Bucio L, et al. Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress. Oxidative medicine and cellular longevity. 2016;2016:7960386.\u003c/p\u003e\n\u003cp\u003e35.Fafalios A, Ma J, Tan X, Stoops J, Luo J, Defrances MC, et al. A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nature medicine. 2011;17(12):1577–84.\u003c/p\u003e\n\u003cp\u003e36.Quilliot D, Alla F, Bohme P, Bruntz JF, Hammadi M, Dousset B, et al. Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance. International journal of obesity. 2005;29(11):1321–8.\u003c/p\u003e\n\u003cp\u003e37.Fay WP. Linking inflammation and thrombosis: Role of C-reactive protein. World journal of cardiology. 2010;2(11):365–9.\u003c/p\u003e\n\u003cp\u003e38.Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. Correlation between mean platelet volume and blood glucose levels after oral glucose loading in normoglycemic and prediabetic Japanese subjects. Journal of diabetes investigation. 2014;5(1):66–71.\u003c/p\u003e\n\u003cp\u003e39.Gang L, Yanyan Z, Zhongwei Z, Juan D. Association between mean platelet volume and hypertension incidence. Hypertension research: official journal of the Japanese Society of Hypertension. 2017;40(8):779–84.\u003c/p\u003e\n"},{"header":"Tables","content":"\u003cp style=\"text-align: left;\"\u003eTable 1. Clinical ,laboratory, and anthropometric data of NAFLD patients compared to controls\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 15.35pt;\"\u003e\n\u003ctd style=\"width: 85.2pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.35pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.35pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eControl group\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.35pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eNAFLD group\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.35pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eStatistics\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 15.35pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eMale/female\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 200%;\"\u003e52/50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 200%;\"\u003e156/144\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.032\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.859\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e54.97\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e12.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e54.19\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e13.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003et\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=0.050\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.614\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eBMI\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e23.96\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.36\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e27.04\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e3.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003et\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-7.864\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eGLU\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e7.48\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e4.13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e9.29\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e25.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-2.131\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.033\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePLT\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: #333333; background: white;\"\u003e10^9/L\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e169.72\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e60.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e201.78\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e66.36\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-4.286\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eALT\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(IU/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e22.69\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e13.05\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e36.02\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e43.16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-3.753\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eAST\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(IU/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e23.53\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e9.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e33.207\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e26.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-3.670\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eALP\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e89.95\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; 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border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTBIL(umol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e12.67\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e11.42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e14.86\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e7.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-4.963\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eDBIL(umol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.17\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.94\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-3.604\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eIBIL(umol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e8.99\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e3.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e11.24\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e5.41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-4.447\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTBA\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e5.322\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e4.46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e7.83\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e9.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-2.639\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.008\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTC(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e4.422\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e4.87\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003et\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-2.905\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.004\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTG(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.95\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.45\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-2.992\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.003\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eLDL\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.49\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e2.72\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003et\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-2.406\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.017\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eHDL\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.03\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e1.11\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-0.771\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.441\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eHGF\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003epg/ml\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e33.18\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e34.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e56.45\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e97.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-3.132\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.002\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 85.2pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003ePCIII\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eng/ml\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e7.82\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e7.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.2pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e15.11\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e13.31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eZ\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e=-4.476\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.25pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eTable 2. the laboratory and clinical characteristics of varying degrees of NAFLD patients and the control group\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: -15.9pt; border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eControl group\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003en=102\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eMild\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003en=119\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eModerate\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003en=156\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eSevere\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003en=25\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eStatistics\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eMale/female\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e52/50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e58/61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e81/75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e17/8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e=3.102\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.376\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e54.97\u0026plusmn;12.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e53.95\u0026plusmn;13.66\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e54.96\u0026plusmn;13.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e50.64\u0026plusmn;14.09\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eF\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e=0.856\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.464\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eBMI(kg/m2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e23.96\u0026plusmn;2.36\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e23.63\u0026plusmn;2.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e28.63\u0026plusmn;1.26\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e33.40\u0026plusmn;2.34\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eab\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eF\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e=247.176\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eGLU(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e5.76\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e5.00\u003cspan style=\"color: black;\"\u003e-8.58\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e6.20\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(5.06-9.35)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e7.50\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(5.85-9.62)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e ab\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; 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font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e30.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eTBIL(umol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; 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font-family: 'Times New Roman',serif;\"\u003e12.80\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(10.50-15.82)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e13.70\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(11.15-19.85)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e36.269\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eDBIL(umol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.10\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.50-3.00)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.10\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.60-3.20)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.30\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.90-3.00)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.10\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.80-2.80)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e14.368\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.002\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eIBIL(umol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e9.45\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(7.08-13.98)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e8.80\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(7.70-13.10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e10.45\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(8.10-12.30)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e11.20\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(9.50-16.55)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e26.493\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eTBA(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.50\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(2.40-7.35)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.70\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(2.60-9.20)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.60\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(2.80-8.17)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e3.70\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eabc\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(2.95-5.45)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e10.747\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.013\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eTC(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.42\u0026plusmn;1.19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.31\u0026plusmn;1.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.56\u0026plusmn;1.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e4.88\u0026plusmn;1.00\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eF\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e=3.578\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.014\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eTG(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e1.60\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.20-2.30)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e1.60\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.12-2.62)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e1.86\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.31-2.59)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e1.95\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eab\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.42-2.38)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e9.098\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.028\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eLDL(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.49\u0026plusmn;0.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.72\u0026plusmn;0.88\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.71\u0026plusmn;0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e2.79\u0026plusmn;0.78\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eF\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e=3.412\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.026\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eHDL(mmol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.97\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(0.84-1.16)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e1.02\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(0.85-1.19)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.97\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(0.85-1.09)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e1.23\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eac\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(0.91-1.30)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e6.801\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.079\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eHGF(pg/m)l\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e18.22\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(11.44-44.22)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e23.85\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(14.35-53.44)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e26.26\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(15.69-99.84)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e35.29\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(13.43-52.94)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e abc\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e11.364\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.010\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003ePCIII(\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eng/ml\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e5.74\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(0.34-23.10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e6.62\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(0.52-12.00)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e8.19\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(1.84-24.61)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e16.13\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e abc\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(8.36-26.28)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: black;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e33.347\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.35pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003ePLT(\u003cspan style=\"background: white none repeat scroll 0% 0%;\"\u003e10^9/L\u003c/span\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003e165.00\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003e(103.75-211.00)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.25pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"91\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003e185.00\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(152.00-224.25)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003e200.00\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(166.00-258.00)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif;\"\u003e a\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003e203.00\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e(166.00-240.00)\u003c/span\u003e\u003csup\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif;\"\u003e ab\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: .75in; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif;\"\u003eH\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif;\"\u003e=\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e24.38\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.9pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Times New Roman', serif; color: #000000;\"\u003e0.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eNote: a: there was a statistically significant difference from the norma\u003c/span\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003el control group, there was a statistical difference. b: there was a statistically significant difference from the mild fatty liver group; C: there was a statistically significant difference from the moderate fatty liver group.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 150%; text-align: left;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 3.\u003c/span\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003eCorrelation analysis of HGF, PCIII and homa-ir with various clinical \u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003eparameters\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 4.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; border-top: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.5pt;\" rowspan=\"2\" width=\"111\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 4.5pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eHGF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; border-top: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 4.5pt;\" colspan=\"2\" width=\"132\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003ePCIII\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; border-top: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.7pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 4.5pt;\" colspan=\"2\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003ePLT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003er\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003er\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003er\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; border-top: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; 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border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eBMI\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.432\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.311\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.004\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.373\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; 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line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.222\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.044\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTBA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.322\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.003\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.164\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.139\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.954\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.162\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.148\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.007\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.948\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.084\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.449\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eTG\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.398\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.180\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.104\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.251\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.022\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eLDL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.269\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.017\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.228\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.041\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.221\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.047\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"width: 83.4pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"111\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eHDL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.329\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.003\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.6pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.169\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.146\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21.2pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"28\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 49.65pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"66\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.901\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 45.05pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"60\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"color: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: black;\"\u003eTable 4 The relationship between HGF, PCIII and PLT and the degree of NAFLD\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 142.0pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003er\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border-top: solid black 1.5pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 142.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eHGF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.501\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 142.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003ePCIII\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.397\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 142.0pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003ePLT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003e0.470\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 142.05pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"189\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: black;\"\u003eTable 5\u0026nbsp;\u0026nbsp; The comparison of the diagnostic performance of HGF, PCIII and PLT in patients with\u0026nbsp; varying degrees of fatty liver\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 24.0pt;\"\u003e\n\u003ctd style=\"width: 51.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"68\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003egroup\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eAUC\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003e95%CI\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"94\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003ecut-off\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eSE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.55pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eSP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 24.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 47.75pt;\"\u003e\n\u003ctd style=\"width: 51.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" rowspan=\"3\" width=\"68\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eHGF\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003epg/ml\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eMild\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.753\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.691-0.809\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e14.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.798\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.588\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.75pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.004\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 47.0pt;\"\u003e\n\u003ctd style=\"width: 52.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eModerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.836\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.785-0.879\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e15.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.833\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.696\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 47.0pt;\"\u003e\n\u003ctd style=\"width: 52.3pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eSevere\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.903\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.837-0.948\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e17.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.920\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.55pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.764\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 47.5pt;\"\u003e\n\u003ctd style=\"width: 51.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" rowspan=\"3\" width=\"68\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003ePC\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: SimSun; color: black;\"\u003eⅢ\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: SimHei; color: black;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; color: black;\"\u003eng/ml\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: SimHei; color: black;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eMild\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.597\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt;\"\u003e0.529-0.662\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e7.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.697\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.568\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e0.114\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 47.0pt;\"\u003e\n\u003ctd style=\"width: 52.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 47.0pt;\" width=\"70\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10.0pt; color: black;\"\u003eModerate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; 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line-height: 150%; color: black;\"\u003e0.990\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.6pt; border: none; border-bottom: solid black 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left;\"\u003enote\u003cspan style=\"font-family: SimSun;\"\u003e：\u003c/span\u003eSE\u003cspan style=\"font-family: SimSun;\"\u003e：\u003c/span\u003e\u003cspan style=\"color: black;\"\u003esensitivity\u003c/span\u003e\u003cspan style=\"font-family: SimSun;\"\u003e；\u003c/span\u003eSP\u003cspan style=\"font-family: SimSun;\"\u003e：\u003c/span\u003e\u003cspan style=\"color: black;\"\u003especificity \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Nonalcoholic fatty liver disease (NAFLD), Hepatocyte growth factor(HGF),Serum type iii procollagen (PCIII),platelet(PLT),Noninvasive diagnostic","lastPublishedDoi":"10.21203/rs.2.18035/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.18035/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground/Aims: It was suggested that serum HGF,PCIII and PLT play important roles in nonalcoholic fatty liver disease (NAFLD). Thus, we aimed to evaluate their clinical utility in the diagnosis of patients with suspected NAFLD.\u003c/p\u003e\u003cp\u003eMethods:300 Patients with NAFLD were compared to 102 matched controls.All were subjected to history taking, anthropometric measurements, and abdominal ultrasonography, as well as laboratory assessments of liver functions, fasting lipid profile, GLU, serum PLT, HGF and PCIII.\u003c/p\u003e\u003cp\u003eResults:The levels of HGF,PCIII and PLT were higher in NAFLD cases than controls ,and with progressive increases as the severity of fatty liver increased（P\u0026lt;0.05）.HGF,PCIII and PLT were correlated with various clinical parameters and severity of NAFLD（P\u0026lt;0.05）.The optimal cut-off values for HGF in diagnosis of mild, moderate and severe fatty liver were 14.1pg/ml(AUROC 0.753,P＝0.004), 15.4pg/ml(AUROC 0.836,\u0026nbsp;P\u0026nbsp;\u0026lt; 0.001), 17.7pg/ml(AUROC 0.903,\u0026nbsp;P\u0026nbsp;\u0026lt; 0.001). PCIII had no value in differentiate mild from moderate fatty liver ,but its ability to diagnose severe fatty liver was significant. A cut-off value for PCIII to diagnose severe fatty liver was 7.9ng/L(AUROC 0.773).The optimal cut-off values for PLT in the diagnosis of mild, moderate and severe fatty liver were 194×10^9/L(AUROC 0.732), 195×10^9/L(AUROC 0.765), 200×10^9/L(AUROC 0.925), respectively with P\u0026nbsp;\u0026lt; 0.001. When three indicators were tested together,the AUROC(95%CI)curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873)(P\u0026lt;0.001) .\u003c/p\u003e\u003cp\u003eConclusion:.Combined detection of serum HGF, PCIII and PLT may be an effective non-invasive method for diagnosing NAFLD.\u003c/p\u003e","manuscriptTitle":"Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-12-04 22:17:53","doi":"10.21203/rs.2.18035/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"22de5f7c-c553-4588-89d3-b13c582a6124","owner":[],"postedDate":"December 4th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":39611,"name":"Gastroenterology \u0026 Hepatology"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-12-04 22:17:53","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8663","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-8663","version":["v1"]},"buildId":"ApUGefWb6u5IBVtyqm6d5","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}