Changes in visceral pain reactivity as a function of estrous cycle in female rats with artificial ureteral calculosis

Maria Adele Giamberardino, Giannapia Affaitati, Rita Valente, Sabina Iezzi, L Vecchiet
In: Brain Research · 1997 · vol. 774(1-2) , pp. 234–238 · doi:10.1016/s0006-8993(97)81711-8 · PMID:9452216 · W2008872570
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Female rats with artificial ureteral stones exhibited significantly higher visceral pain reactivity, as measured by time spent in behavioral crises, during metestrus/diestrus compared to proestrus/estrus.

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Abstract

This study examined estrous differences in the characteristics of behavioral crises of visceral pain in female rats video-taped throughout a 4-day period after implantation of an artificial stone in one ureter. All animals continued to have a regular cycle after ureteral surgery. In the recording period, the percentage of time spent in crises was significantly higher during metestrus/diestrus (M/D) than during proestrus/estrus (P/E) (P < 0.001, chi2-test). Mean duration and complexity of crises were slightly higher in M/D than in P/E, but the difference was not significant. The results in this animal model show an enhancement of ureteral pain sensitivity in M/D, a finding in line with the clinical observation, in fertile women with urinary calculosis, of a greater incidence of colics in the perimenstrual period (equivalent to M/D in rats).

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