PREPARATION OF SUBSTITUTED QUINAZOLINES.

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-) 3-chloro -4- floro- phenylamino) -7-(3- morpholin-4 -yl- propoxy) -quinazolin -6-yl] -acrylamide, are useful for treating cancer, retenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.