PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH NAGAMERAH (HYLOCEREUS POLYRHIZUS) BERBAGAI DOSIS TERHADAPKADAR INTERLEUKIN-6, EKSPRESI CASPASE-3, DAN JUMLAHAPOPTOSIS SEL GRANULOSAPenelitian Eksperimental Pada Hewan Coba Mencit Model Endometriosis

One of the infertility mechanisms associated with endometriosis is the immune response in peritoneal zalir in the form of increased macrophages and excessive secretion of some cytotine such as IL-6 which binds to its receptors leading to activation of NF-KB in granulose cells inducing genes involved in inflammatory and apoptotic responses. The secretion of the cytokine is inhibited by preventing the activation of NF-KB using the extract of red dragon fruit peel. This research is aimed at studying the effect ethanol extract taken from red dragon fruit peel with doses of 0.25; 0.5; and 1mg/g Body weight to IL-6 concentration, caspase 3 expression and number of apoptotic granulose cell in endometriosis mice model. The sample consisting of 30 female mice were devided into 5 for each groups. The groups were of negative group, positive group, and graded dose treatment group. Positive control and treatment were endometriosis for 14 days, the next 14 days negative and positive group were given 0.5% Na-CMC solution, while treatment group was given graded doses. This type research is true experimental using the randomized post test only control group experimental. The results of this research significant differences in IL-6 concentration, caspase-3 expression, and number of apoptotic granulose cell in the control and treatment groups. Extract of hylocereus polyrhizus peel on endometriosis mice can suppress IL-6 concentration, caspase-3 expression, and number of apoptotic granulose cell with p<0.05 significanse