Sexual function, depression, anxiety, and vulvovaginal candidiasis

We read the paper by Moshfeghy et al. ( 1 ) entitled “association of sexual function and psychological symptoms including depression, anxiety, and stress in women with recurrent vulvovaginal candidiasis” published in June 2020, volume 21, issue 2 of your journal with great interest. Female sexuality is a highly complex and multifactorial issue. The effect of the vaginitis that every woman experiences “at least once” in her lifetime, especially candidal, on sexual function cannot be underestimated. The authors aimed to make an objective assessment, as far as possible, using the Female Sexual Function Index (FSFI) the most commonly used questionnaire in the world for this assessment. However, in our opinion determining some other variables while evaluating the problem could strengthen the study. In addition, when examining the regression analysis, it is unclear if this was univariate or multivariate and, therefore, the relationship of the variables with the subject is not revealed. We would like to highlight three issues on this subject. Firstly, and most importantly, the demographic characteristics of the patients have not been presented. The characteristics of the study and control groups such as age, body mass index (BMI), occupation, education level, and substance addiction were not given. Especially, age affects sexual functions concerning BMI body perception. The second important issue was the respective “male sexual” function. According to the “Global Study of Sexual Attitudes and Behaviors”, 28% of sexually active men in the general population have at least one sexual problem ( 2 ). Periodic to frequent early ejaculation was reported by 14% of men, slightly more frequently than erection difficulties (10%), and a total of 9% complained of lack of interest in sex ( 2 ). These male dysfunctions will clearly also affect female sexual function ( 3 ). In all societies, especially in developing countries, the effect of male sexual dysfunctions on women is overlooked. It is acceptable that this study did not include an evaluation of male sexual function, but it might be appropriate to mention it as an important limitation. The third and last issue is that conditions such as polycystic ovary syndrome (PCOS), endometriosis, pelvic masses, and urinary incontinence, which can cause psychological and sexual dysfunction in women, have not been excluded. For instance, although different results were reported for sexual dysfunction in PCOS patients, it was stated that depression and anxiety are more common in these patients and, in evaluations made with FSFI, there are often variations in satisfaction scores, especially concerning hirsutism and BMI ( 4 , 5 ). Considering the results reported by the authors, mentioning these factors, which have been reported to have an effect on depression, anxiety, and sexual function, would provide a clearer evaluation of the findings of the study for us readers.