Multiple Sclerosis and Occupational Outcomes in the Context of the COVID-19 Era: A Scoping Review

The COVID-19 pandemic has disrupted both health and occupational functioning for people with multiple sclerosis (PwMS). This review synthesizes evidence from 51 studies (18,379 PwMS) on psychological, social, and work-related outcomes during the pandemic. Findings indicate elevated depression and stress, variable anxiety, and substantial employment disruption, including job loss, reduced hours, and shifts to remote work. Socioeconomic stressors compounded these effects, while workplace accommodations were rarely assessed. Evidence gaps remain regarding occupation-specific hazards, lived experiences, and long-term outcomes. These results underscore the need for disability-inclusive employment policies, mental-health support, and longitudinal research to guide interventions for PwMS in crisis contexts.