Changes in Oxidative Stress Parameters as Response to Supplementation With Vitamin E and Omega-3 Fatty Acids in Male Workers Exposed to High Level Noise

Abstract Background: The present study aimed to assess the effects of the supplementation consumption of vitamin E and Omega 3 fatty acid on the oxidative stress parameters among workers exposed to high levels of noise in an automobile parts manufacturing plant. Moreover, the effects of the exposure to noise on SOD, total oxidative stress (TAC) and MDA will be investigated. Methods: The participants were deployed into 4 groups (vitamin E (100 mg), Omega 3 fatty acids (180 mg EPA and 120 mg DHA), vitamin E+ Omega 3 and Placebo), as per the double-blind block randomization method. The oxidative stress parameters of the participants were analyzed before and after three month consumption of supplements via enzyme-linked immunosorbent assay method. The level of workers' exposure to noise, was measured according to ISO 9612. Results: Before intervention, mean MDA, SOD and TAC were 27.52 (7.46) nmol/ml, 58.84 (10.44) U/ml and 2.57 (0.67) mM respectively. After intervention, mean MDA, SOD and TAC were 24.57 (7.58) nmol/ml, 63.46 (11.02) U/ml and 2.70 (0.84) mM respectively. The use of supplement Omega 3 fatty acids had a significant decremental effect on MDA levels. The use of vitamin E alongside Omega 3 fatty acids had a significant incremental effect on SOD activity.Conclusion: Noise exposure had a decremental effect on TAC and SOD as well as an incremental effect on MDA, but this was only statistically significant for TAC. It appears that the simultaneous use of vitamin E and Omega 3 fatty acids for three months had a positive effect on the anti-oxidant performance of workers exposed to noise.