Ovarian endometrioid carcinoma with diffuse pigmented peritoneal keratin granulomas: a case report and review of the literature

T I Wu, Tzu-I Wu, T C Chang, Ting-Chang Chang, S Hsueh, Chyong‐Huey Lai, C H Lai
International Journal of Gynecological Cancer · 2006 · vol. 16(1) , pp. 426–429 · doi:10.1111/j.1525-1438.2006.00202.x · PMID:16445670 · W1975813995
Review OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-09-06 ⓘ

This case report describes an ovarian endometrioid carcinoma patient with diffuse pigmented peritoneal keratin granulomas, demonstrating that immunostaining and DNA flow cytometry can distinguish viable tumor cells from granulomatous components to guide chemotherapy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The presence of keratin granulomas in peritoneal cavity associated with ovarian endometrioid carcinoma, which might be related to leakage from the ovarian tumor, is rarely reported. Its clinical significance has not yet been well investigated. We report a case presenting with intermittent abdominal pain after an acute episode 1 month before a complex adnexal tumor was noted. Comprehensive cytoreductive surgery was performed. The ovarian tumor was an endometrioid adenocarcinoma with squamous differentiation. There were diffuse brownish flecks over the omental surface and pelvic peritoneum, which contained fragments of degenerated squamous cells, keratin, and numerous foreign body giant cells. Extensive multiple sections were examined for these implants. DNA flow cytometry and various immunostaining studies (HER-2/neu, p53, CK-7, and cytokeratin [AE1/AE3]) were performed. Since viable epithelial cells in the implants could be differentially identified against mesothelial or granulomatous components by CK-7 staining and DNA aneuploidy was demonstrated on primary ovarian tumor, four courses of chemotherapy were administered. The patient has been free of disease for 18 months since diagnosis.

My notes (saved in your browser only)

MeSH descriptors

Carcinoma, Endometrioid Granuloma Lymph Nodes Ovarian Neoplasms Peritoneal Diseases Abdominal Pain Abdominal Pain Abdominal Pain Biopsy, Needle Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Female Flow Cytometry Follow-Up Studies Frozen Sections Granuloma Granuloma Humans Immunohistochemistry

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (10)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:03:37.664955+00:00
unpaywall
last seen: 2026-10-10T06:25:47.132674+00:00
License: CC0 · commercial use OK