The Classic WNT Pathway Modulates Umbilical Cord-Derived Mesenchymal Stromal Cells in Restoring Hepatic Microenvironment Homeostasis Related Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) specifically includes the stage of simple fatty liver and the stage of hepatitis. In the late stage of the disease, it resembles the early stage of cirrhosis. Mesenchymal stem cells regulate metabolic pathways and energy transport pathways in disease models, reducing the synthesis and utilization of glucose and fatty acids, and restoring the homeostasis of the internal microenvironment. For areas with more severe damage, umbilical cord mesenchymal stem cells (UCMSC) are used for regenerative repair. Mesenchymal stem cells release exosomes in a paracrine manner into the damaged areas of the liver, promoting the differentiation and development of hepatic progenitor cells into hepatocytes, reducing differentiation into cholangiocytes, while assisting hepatic progenitor cells in resisting the progression of inflammation and fibrosis, and promoting the normal function of adaptive immune responses.