Biomarkers in Hip Dysplasia: a Scoping Review

Background Hip dysplasia is a congenital condition affecting around 5% of the population and is a major risk factor for secondary osteoarthritis and hip arthroplasty. While biomarkers have been widely studied in primary osteoarthritis, their role in hip dysplasia remains unclear. Understanding biomarker profiles in this patient population may aid in the development of preventive and non-surgical treatment strategies, as well as monitoring the effects of surgical interventions and physical activity.

To systematically map and summarize the current evidence on biomarkers in patients with hip dysplasia.

This scoping review will follow the PRISMA-ScR guideline. Eligible studies include interventional and observational studies published in peer-reviewed journals reporting biomarker data in patients with hip dysplasia. Animal studies, conference abstracts, and studies not reporting hip dysplasia data separately will be excluded. We will search MEDLINE, Embase, and CENTRAL without study design or date restrictions, but limited to English-language publications. Two reviewers will independently screen studies and extract data, which will be synthesized in tables and summarized narratively. Dissemination The findings will be published in an international peer-reviewed journal and may inform research on disease-modifying treatments and prevention of osteoarthritis in hip dysplasia. Study registration This protocol is uploaded to MedRxiv.org Funding The review is investigator-initiated. Any costs in connection with the study will relate to the salary of the investigators and are provided by the department. Competing Interest Statement The authors have declared no competing interest. Funding Statement This study did not receive any funding Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data Availability All data produced will be availabl eupon request to the authors, when the review is published and is.