Distribution of Interleukin-6 Gene Promoter Region Mbi I Polymorphism in Patients with Endometriosis and Patients with Myoma of Uterus

Objective:To detect the distribution of interleukin-6gene promoter region Mbi I in patients with endometriosis 、patients with myoma of uterus and normal controls.Methods:Interleukin-6 gene promoter region Mbi I polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with endometriosis(n=98) ,patients with myoma of uterus(n=97) and normal controls(n=99).Results:The frequencies of CC,CG and GG genotypes were 55.10%,42.86% and 2.04%in patients with endometriosis,while 71.13%,27.84% and 1.03% in patients with myoma of uterus, and 70.71%,28.28% and 1.01% in normal controls. A significant difference was seen in the distribution frequency of interleukin-6 genotype between patients with endometriosis and patients with myoma of uterus, patients with endometriosis and normal controls.There was no significant difference in the distribution frequency of interleukin-6 genotype between patients with myoma of uterus and normal controls.Conclusion:The distribution frequency of interleukin-6 genotype has something to do with morbility of endometriosis but have nothing to do with that of myoma of uterus.