Leptin in non-autoimmune inflammation

Chunlin Cai, Cai C, Hahn BH, Bevra H. Hahn, Giuseppe Matarese, La Cava A, Antonio La Cava
Inflammation & allergy drug targets · 2009 · doi:10.2174/187152809789352168 · PMID:19754412
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This review examines leptin's role in non-autoimmune inflammatory diseases including renal, liver, lung, atherosclerosis, metabolic syndrome, Behçet's disease, and endometriosis.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-05 · read from full text ⓘ

This review examines the role of leptin, an adipokine that modulates energy homeostasis and pro-inflammatory immune responses, in non-autoimmune inflammatory diseases. The authors specifically discuss its involvement in renal, liver, and lung inflammation, as well as atherosclerosis, metabolic syndrome, and Behçet's disease. The paper highlights how leptin contributes to the pathogenesis of these conditions beyond its known association with autoimmune disorders like type-1 diabetes. Relevance to endometriosis: listed as one indication for leptin's role in non-autoimmune inflammation, though the paper's main focus is broader metabolic and organ-specific inflammatory processes.

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Abstract

Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis.
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Abstract

Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behcets disease and endometriosis.

Keywords

Leptin, inflammation, metabolism 31

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Condition tags

endometriosis

MeSH descriptors

Leptin Leptin Metabolic Diseases Recombinant Proteins Recombinant Proteins Animals Humans Inflammation Leptin Leptin Leptin Lipid Metabolism Metabolic Diseases Metabolic Diseases Metabolic Diseases Metabolic Diseases Oxidative Stress Recombinant Proteins Recombinant Proteins Recombinant Proteins

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europepmc
last seen: 2026-09-06T09:34:12.023084+00:00
pubmed
last seen: 2026-05-13T22:13:59.677786+00:00
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