Spatiotemporal Dysfunction of Cardiac-driven Cortical Gradients in Coronary Artery Disease for Emotional Regulation

Spatiotemporal Dysfunction of Cardiac-driven Cortical Gradients in Coronary Artery Disease for Emotional Regulation | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Spatiotemporal Dysfunction of Cardiac-driven Cortical Gradients in Coronary Artery Disease for Emotional Regulation Taicheng Huang, Weijing Wang, Ya Gao, Ze Song, Ji-Yu Xie, Liang-Yuan Song, and 11 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7222090/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Depression and anxiety are highly prevalent among patients with coronary artery disease (CAD), suggesting direct interactions between cardiovascular pathology and brain function. However, the influence of cardiac modulation on neural activity remains poorly understood. Here, through simultaneous EEG-ECG recordings in healthy individuals and CAD patients, we characterize the spatiotemporal organization of heart-evoked potentials (HEPs) and their disease-related alterations. We identify a conserved anterior-posterior cortical gradient featuring prefrontal suppression and occipital enhancement that dynamically modulates across the cardiac cycle, attenuating before systole and peaking after the R-wave. Notably, while CAD patients preserve this overall gradient, they exhibit region-specific disturbances including prefrontal hypoactivation and parietal hyperactivation. These pathological changes in cardiac-driven cortical processing correlate with depressive and anxiety symptomatology. Our results provide a systematic framework for understanding how cardiovascular disease disrupts neurocardiac communication, potentially contributing to neuropsychiatric comorbidities in CADs. Health sciences/Diseases/Psychiatric disorders/Depression Health sciences/Diseases/Cardiovascular diseases/Arrhythmias Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7222090","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":499403878,"identity":"e9692df0-a292-40b7-9d53-a92dbe64f8a5","order_by":0,"name":"Taicheng 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