Global burden, trends, and projections of pelvic organ prolapse from 1990 to 2021: a systematic analysis based on GBD and Mendelian randomization

Global burden, trends, and projections of pelvic organ prolapse from 1990 to 2021: a systematic analysis based on GBD and Mendelian randomization | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 24 May 2025 V1 Latest version Share on Global burden, trends, and projections of pelvic organ prolapse from 1990 to 2021: a systematic analysis based on GBD and Mendelian randomization Authors : Zhengkun Wang 0009-0008-7301-9497 , Yi Rong , Qiwei Wang , and Weibing Shuang [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174811340.04646224/v1 315 views 155 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background Pelvic organ prolapse (POP) represents a major global health challenge for women. This study systematically analyzed the global disease burden of POP and associated risk factors from 1990 to 2021, including projections of future trends. Methods The data were derived from the GBD 2021 database and genome-wide association studies (GWAS). Additionally, we combined the age-period-cohort (APC) model with the autoregressive integrated moving average (ARIMA) model to analyze the driving factors and project future disease burden trends. Furthermore, we conducted a two-sample Mendelian randomization (MR) analysis to evaluate the causal relationships between risk factors and POP. Results From 1990 to 2021, the global crude incidence, prevalence, and disability-adjusted life years (DALYs) of POP increased by 66.2%, 68.7%, and 67.5%, respectively. However, in 2021, the global age-standardized disability rate (ASDR) of POP was 18.4% lower than in 1990. Notably, regions with a low sociodemographic index (SDI) exhibited a statistically significant elevation in disease burden. Furthermore, obese populations had a higher risk of developing POP, while those with higher education levels had a lower risk. According to the ARIMA model, global POP cases are projected to reach 148 million by 2036, while the age-standardized prevalence rate (ASPR) and ASDR are expected to decline further by 10.8% and 18.4%, respectively. Conclusion Aging population and socioeconomic inequality will further aggravate the disease burden of POP. To reduce the disease impact, future efforts should focus on strengthening global monitoring, optimizing medical resource allocation, and implementing targeted prevention and control strategies for high-risk populations. Supplementary Material File (figure 2.pdf) Download 17.40 MB File (manuscript.docx) Download 6.94 MB File (table 1.docx) Download 23.62 KB Information & Authors Information Version history V1 Version 1 24 May 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords epidemiology global disease burden health inequity mendelian randomization pelvic organ prolapse Authors Affiliations Zhengkun Wang 0009-0008-7301-9497 First Hospital of Shanxi Medical University View all articles by this author Yi Rong First Hospital of Shanxi Medical University View all articles by this author Qiwei Wang First Hospital of Shanxi Medical University View all articles by this author Weibing Shuang [email protected] First Hospital of Shanxi Medical University View all articles by this author Metrics & Citations Metrics Article Usage 315 views 155 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Zhengkun Wang, Yi Rong, Qiwei Wang, et al. Global burden, trends, and projections of pelvic organ prolapse from 1990 to 2021: a systematic analysis based on GBD and Mendelian randomization. Authorea . 24 May 2025. DOI: https://doi.org/10.22541/au.174811340.04646224/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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