Investigation of oxidative balance in patients with dysmenorrhea by multiple serum markers.

Turhan N, Celik H, Duvan Cİ, Onaran Y, Aydın M, Armutcu F
Journal of the Turkish German Gynecological Association · 2012 · doi:10.5152/jtgga.2012.36 · PMID:24592048 · PMC3881713
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This study measured serum oxidative markers in women with primary dysmenorrhea and found significantly elevated malondialdehyde levels compared to controls, indicating slightly aggravated oxidative stress without correlation to pain severity.

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This study evaluated oxidative stress levels in 33 women with primary dysmenorrhea compared to 25 healthy controls using serum markers including malondialdehyde, nitrotyrosine, deoxyguanosine, and superoxide dismutase. The results indicated significantly elevated malondialdehyde levels in the dysmenorrhea group, suggesting a slight aggravation of oxidative stress, while other markers showed no significant differences. Researchers noted that there was no correlation between the severity of menstrual pain and the measured oxidative marker levels. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

ObjectiveTo investigate the level of oxidative stress in patients with dysmenorrhea by multiple serum markers including malondialdehyde (MDA), nitrotyrosine (3-NT), deoxyguanosine (8-OHdG) and superoxide dismutase (SOD).Material and methodsFifty-eight women, aged between 20 and 34, who had had regular menses for at least six previous cycles, were involved. The women were divided into two groups. The study group consisted of 33 patients with primary dysmenorrhea, and the control group consisted of 25 healthy women.ResultsDemographic characteristics of patients were similar between the two groups. The serum MDA levels were 1.32±0.46 and 0.91±0.26 nmol/mL for the dysmenorrhea and control groups, respectively (p0.05). Also, no correlation was found between the severity of dysmenorrhea and the levels of oxidative markers.ConclusionOxidative stress is slightly aggravated in patients with dysmenorrhea.
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Abstract

Objective: To investigate the level of oxidative stress in patients with dysmenorrhea by multiple serum markers including malondialdehyde (MDA), nitrotyrosine (3-NT), deoxyguanosine (8-OHdG) and superoxide dismutase (SOD).

Material and methods

Fifty-eight women, aged between 20 and 34, who had had regular menses for at least six previous cycles, were involved. The women were divided into two groups. The study group consisted of 33 patients with primary dysmenorrhea, and the control group consisted of 25 healthy women.

Results

Demographic characteristics of patients were similar between the two groups. The serum MDA levels were 1.32±0.46 and 0.91±0.26 nmol/mL for the dysmenorrhea and control groups, respectively (p0.05). Also, no correlation was found between the severity of dysmenorrhea and the levels of oxidative markers.

Conclusion

Oxidative stress is slightly aggravated in patients with dysmenorrhea.

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