Nutritional Considerations Regarding the Role of MicroRNAs in the Regulation of Obesity-Related Breast Cancer

Every year, more and more women are diagnosed with breast cancer, making it the most frequent malignancy among women. Obesity has been recognized as one of the key risk factors for breast cancer development. Although the exact mechanisms by which obesity promotes breast cancer progression remain unclear, several have been identified as likely contributors: insulin resistance, chronic inflammation and inflammatory cytokines, adipokines, and sex hormones. Several disorders, including obesity and breast cancer, have been shown to have altered microRNA (miRNA) expressions, although the implications of miRNAs in obesity-linked breast cancer are just now becoming clear. Obese cancer patients may benefit from using miRNAs as therapeutic targets and noninvasive indicators for diagnosis and prognosis. Recent research has shown that some foods and other dietary components may inhibit the development of cancer and obesity by influencing the production of microRNAs. In this review, we compile the most recent data available on microRNAs (miRNAs) and the molecular targets they regulate in obesity-related breast cancer. Here, we discuss the protective functions of miRNAs in obesity-related breast cancer and the mechanisms by which dietary variables affect miRNA expression. New therapeutic options for the treatment of obesity-associated breast cancer are needed to lessen the disease's prevalence, hence this review was conducted in that spirit.