Controlled Liquid Antisolvent Precipitation of Hydrophobic Pharmaceutical Nanoparticles in a Microchannel Reactor

Hong Zhao, Jie‐Xin Wang, Qian Wang, Jian‐Feng Chen, Jimmy Yun
In: Industrial & Engineering Chemistry Research · 2007 · vol. 46(24) , pp. 8229–8235 · doi:10.1021/ie070498e · W2055687426
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Liquid antisolvent precipitation in a microchannel reactor synthesized additive-free danazol nanoparticles with reduced size and enhanced dissolution rates, demonstrating the method's potential for preparing uniform hydrophobic drug particles.

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Abstract

Microchannel reactors are a rapidly emerging and promising technology field for their enhanced mass transfer and excellent heat exchange induced by dimensional effects. A method, the liquid antisolvent precipitation (LASP) process in a microchannel reactor (MCR), is proposed here to directly synthesize danazol nanoparticles without additives. The mean particle size decreased from 55 μm to 364 nm, and the specific surface area increased from 0.66 to 14.37 m2/g after the LASP process in MCR. The mean particle size can be facilely controlled by regulating the parameter of the MCR setup. The chemical composition and physical characteristics of the as-prepared danazol nanoparticles were demonstrated to be unchanged after processing according to FT-IR and XRD analyses. Correspondingly, the dissolution rate of the nanoparticles within 5 min was enhanced from 35% to 100% compared to the raw danazol particles. Combined with the controlled LASP method, MCR exhibits great potential for preparation of hydrophobic drugs with uniform particle size distribution in the nanometer range.

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