Sorting of mesoporous silica derivatives by random optical fields

Sorting of mesoporous silica derivatives by random optical fields | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Sorting of mesoporous silica derivatives by random optical fields Mohammad Hadi Sadri, Ramin Jamali, Asif Jamal Khan, Fozia Rehman, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4337890/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Mesoporous silica particles are promising candidates for drug delivery applications. In this paper, we first synthesize meso-porous silica MCM-41 and its derivative MCM-41GA with anchored glutaraldehyde bridges, and characterize them using a variety of techniques, including nitrogen adsorption/desorption, X-ray diffraction, NMR spectroscopy, scanning electron microscopy, and thermogravimetric analysis. Then, we employ random optical fields to sort mesoporous silica particles. Random optical fields by containing local intensity gradients throughout a wide range of field of view provide an elegant, easy-to-implement, and low-cost variant of multiple optical tweezers, which is known as speckle tweezers (ST). ST, similar to multiple optical tweezers, for manipulation tasks, such as trapping, sorting, and guiding of collection of micro and sub-micro objects in several disciplines including statistical physics, chemistry, microfluidics and material science. We show that ST can restrict, sieve, and sort MCM-41 and MCM-41GA particles. The different interaction of mesoporous silica variations with the applied ST may be attributed to the pre-applied modification and the differences in the porosity structure and distribution. Therefore, the results provide insight into the textural and chemical characteristics of mesoporous materials, contributing to a deeper understanding of their potential applications. Physical sciences/Optics and photonics/Applied optics Physical sciences/Materials science Physical sciences/Optics and photonics/Optical techniques Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4337890","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":299428740,"identity":"08e343af-5683-4a79-9ea0-b4f65bc5a2cf","order_by":0,"name":"Mohammad Hadi Sadri","email":"","orcid":"","institution":"Institute for Advanced Studies in Basic Sciences (IASBS)","correspondingAuthor":false,"prefix":"","firstName":"Mohammad","middleName":"Hadi","lastName":"Sadri","suffix":""},{"id":299428742,"identity":"12840b40-e886-4b9d-bbd7-e536f8e3f4a0","order_by":1,"name":"Ramin Jamali","email":"","orcid":"","institution":"Institute for Advanced Studies in Basic Sciences (IASBS)","correspondingAuthor":false,"prefix":"","firstName":"Ramin","middleName":"","lastName":"Jamali","suffix":""},{"id":299428744,"identity":"780c8254-6e67-4867-8009-7f9045676e18","order_by":2,"name":"Asif Jamal Khan","email":"","orcid":"","institution":"Northwest University","correspondingAuthor":false,"prefix":"","firstName":"Asif","middleName":"Jamal","lastName":"Khan","suffix":""},{"id":299428746,"identity":"393d7813-05dd-4381-aab9-7a14448677fc","order_by":3,"name":"Fozia Rehman","email":"","orcid":"","institution":"São Paulo State University (UNESP)","correspondingAuthor":false,"prefix":"","firstName":"Fozia","middleName":"","lastName":"Rehman","suffix":""},{"id":299428748,"identity":"5fa8d950-091f-43bc-88bb-a01c24490ae8","order_by":4,"name":"Ali-Reza Moradi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA1klEQVRIiWNgGAWjYLACHoMEBn5mBgZmCJexgTgtks2kaWFIYDA4ANdCAOi29z788KYgTd74OPPjzwV/GOT5G5jbPuDTYnbmuLHkHIMcw22H2cykZ7YxGM44wNg8A6+WG2kM0jwGFYzbDjOYMfM2MDBuYGBsxuswoBbm30At9pub2T9/5vnDYE+MFjagLTmJG5h5DKR52BgSCWs5c4zNco5BWvKMwzxlQL9IABmEtBxvY77x5k+ybX//8c3AELOx7W9vf4xXCzqQIDZ2RsEoGAWjYBTgAwCAI0LBOIGoDAAAAABJRU5ErkJggg==","orcid":"","institution":"Institute for Advanced Studies in Basic Sciences (IASBS)","correspondingAuthor":true,"prefix":"","firstName":"Ali-Reza","middleName":"","lastName":"Moradi","suffix":""}],"badges":[],"createdAt":"2024-04-28 12:21:58","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4337890/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4337890/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":57387302,"identity":"28533e87-5df1-4464-98d0-fb074ee94d75","added_by":"auto","created_at":"2024-05-30 04:16:07","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2852022,"visible":true,"origin":"","legend":"","description":"","filename":"SR2024MCMmanuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4337890/v1_covered_247b76a1-79ad-48a8-aa98-2e5c9e3a7d9d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Sorting of mesoporous silica derivatives by random optical fields","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4337890/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4337890/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Mesoporous silica particles are promising candidates for drug delivery applications. In this paper, we first synthesize meso-porous silica MCM-41 and its derivative MCM-41GA with anchored glutaraldehyde bridges, and characterize them using a variety of techniques, including nitrogen adsorption/desorption, X-ray diffraction, NMR spectroscopy, scanning electron microscopy, and thermogravimetric analysis. Then, we employ random optical fields to sort mesoporous silica particles. Random optical fields by containing local intensity gradients throughout a wide range of field of view provide an elegant, easy-to-implement, and low-cost variant of multiple optical tweezers, which is known as speckle tweezers (ST). ST, similar to multiple optical tweezers, for manipulation tasks, such as trapping, sorting, and guiding of collection of micro and sub-micro objects in several disciplines including statistical physics, chemistry, microfluidics and material science. We show that ST can restrict, sieve, and sort MCM-41 and MCM-41GA particles. 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